Intranasal oxytocin

ApprovedSmall molecule

UUniversity of Electronic Science and Technology of China

Intranasal oxytocin is one of 364 small molecule programs targeting Frontotemporal Dementia. It is currently in Approved.

Indications

Total Trials

Active Trials

363

Competitors

Pipeline

Status by Indication[3][1]

Indication

Frontotemporal DementiaActive, not recruiting

Tic DisorderActive, not recruiting

Prader-Willi SyndromeActive, not recruiting

Anorexia NervosaActive, not recruiting

Borderline Personality DisorderActive, not recruiting

Social BehaviorActive, not recruiting

Opioid DependenceActive, not recruiting

Drug DependenceActive, not recruiting

Alcohol DependenceActive, not recruiting

Autism Spectrum DisorderActive, not recruiting

Frontotemporal DementiaPreclinical

Active, not recruiting

Tic DisorderPhase 1

Active, not recruiting

Prader-Willi SyndromePhase 2

Active, not recruiting

Anorexia NervosaPhase 1

Active, not recruiting

Borderline Personality DisorderPreclinical

Active, not recruiting

Social BehaviorPhase 1

Active, not recruiting

Opioid DependencePhase 1/Phase 2

Active, not recruiting

Drug DependenceApproved

Active, not recruiting

Alcohol DependencePhase 2

Active, not recruiting

Autism Spectrum DisorderPreclinical

Active, not recruiting

Showing 10 of 16 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Intranasal oxytocin

UUniversity of Electronic Science and Technology of China

Approved

1 2

Blenoxane

Bristol-Myers Squibb

Preclinical

1 3

Lexiscan

Astellas

Preclinical

1 4

Adenocard

Astellas

Preclinical

1 5

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 6

Zoladex

Luye Pharma Group Ltd.

Preclinical

8 7

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

3 8

Neoadjuvant Therapy

SSun Yat-sen University

Preclinical

3 9

Motexafin Gadolinium

PPharmacyclics LLC.

Preclinical

1 10

Neoadjuvant Treatment

SShanghai Zhongshan Hospital

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Treatment

NCT04523922

Clinical

Trials by Indication[1]

Oxytocin19 trials

Intranasal Oxytocin and Maternal Neglect

Completed·—·N/A·NCT02737436·132 enrolled

Stimulant Oxytocin Study

Completed·VVA Office of Research and Development·Phase 2·NCT03016598·42 enrolled

The Effects of Oxytocin Administration to Patients and Therapists on Physiological Synchronization

Recruiting·SShalvata Mental Health Center·Phase 2·NCT05432089·120 enrolled

Show 16 more trials

Oxytocin and the Social Brain

Completed·UUniversity of California, Los Angeles·Phase 1·NCT02393456·161 enrolled

Oxytocin Modulates Eye Gaze Behavior During Social Processing

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03293511·40 enrolled

The Effects of Oxytocin on Affective Touch

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT03282162·50 enrolled

The Effects of Oxytocin and Vasopressin on Delta-beta Cross-frequency Coupling

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT06605300·120 enrolled

Effects of Intranasal Oxytocin on Fear Processing in Naturalistic Contexts

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT05892939·69 enrolled

Oxytocin Aging Study

Terminated·UUniversity of Florida·Phase 1·NCT02069431·153 enrolled

Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency

Recruiting·EElizabeth Austen Lawson·Phase 1·NCT04789148·40 enrolled

Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT06405737·80 enrolled

Oxytocin and Pain Sensitivity and Threshold

Withdrawn·NNorthwestern University·N/A·NCT01988649

Inhaled Oxytocin and HPA Axis Reactivity

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT03593473·109 enrolled

Oxytocin and Learning for Teaching

Completed·UUniversity of California, Los Angeles·Phase 1·NCT02393443·161 enrolled

Target Engagement for Oxytocin: Dose Ranging Study

Completed·UUniversity of California, Los Angeles·N/A·NCT02498236·51 enrolled

The Effects of Oxytocin on Social Touch

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03278860·50 enrolled

The Effects of Intranasal and Oral Administration of Oxytocin on Responses to Emotional Scenes

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT05532501·160 enrolled

Effects of Oxytocin on Reinforcement Learning

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT03846271·40 enrolled

Effects of Oxytocin on Reinforcement Learning and Interoception

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT05245708·80 enrolled

Autism Spectrum Disorder7 trials

Probiotics and Oxytocin Nasal Spray on Social Behaviors of Autism Spectrum Disorder (ASD) Children

Completed·MMassachusetts General Hospital·Phase 1·NCT03337035·35 enrolled

INtranasal OXyTocin for the Treatment of Autism Spectrum Disorders

Completed·HHolland Bloorview Kids Rehabilitation Hospital·Phase 2·NCT01788072·70 enrolled

A Study of Oxytocin for the Treatment of Social Impairment in Individuals With High Functioning Autism Spectrum Disorder

Completed·MMassachusetts General Hospital·Phase 3·NCT02985749·7 enrolled

Show 4 more trials

Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Adults With Autism Spectrum Disorder

Completed·OOptiNose AS·Phase 1/2·NCT02414503·17 enrolled

Intranasal Oxytocin for the Treatment of Autism Spectrum Disorders

Completed·MMontefiore Medical Center·N/A·NCT01337687·19 enrolled

An Open-Label Trial of Oxytocin in Adolescents With Autism Spectrum Disorders

Completed·MMassachusetts General Hospital·N/A·NCT01931033·8 enrolled

Intranasal Oxytocin for the Treatment of Children and Adolescents With Autism Spectrum Disorders (ASD)

Completed·HHolland Bloorview Kids Rehabilitation Hospital·Phase 2·NCT01908205·60 enrolled

Prader-Willi syndrome3 trials

Oxytocin Trial in Prader-Willi Syndrome

Completed·UUniversity of Florida·Phase 1·NCT02013258·24 enrolled

Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome

Completed·MMontefiore Medical Center·Phase 2·NCT02629991·23 enrolled

Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome

Completed·EEric Hollander·Phase 2·NCT03197662·32 enrolled

Alcohol Withdrawal3 trials

Oxytocin and Alcohol Withdrawal and Dependence

Completed·NNorwegian University of Science and Technology·Phase 3·NCT02903251·40 enrolled

Intranasal Oxytocin Effects in Alcohol Withdrawal and Dependence; Follow-up Study

Completed·NNorwegian University of Science and Technology·Phase 3·NCT03339024·38 enrolled

Oxytocin Treatment of Alcohol Withdrawal

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01212185·14 enrolled

Frontotemporal Dementia2 trials

Oxytocin and Social Cognition in Frontotemporal Dementia

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·N/A·NCT01002300·24 enrolled

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2·NCT01937013·52 enrolled

24 more indications

Social Behavior2 trials

Effects of Intranasal Oxytocin and Vasopressin on Social Behavior and Decision Making

Unknown status·DDavid Mankuta·N/A·NCT02526914·432 enrolled

Neuropeptides and Social Behavior

Completed·UUniversity of California, Los Angeles·Phase 1·NCT01680718·160 enrolled

Treatment2 trials

The Effects of Oxytocin Treatment on Social Touch

Completed·UUniversity of Electronic Science and Technology of China·N/A·NCT05265806·180 enrolled

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

Recruiting·MMedical University of South Carolina·Phase 2·NCT04523922·180 enrolled

Alcohol Dependence2 trials

Oxytocin Treatment of Alcohol Dependence

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT02251912·22 enrolled

Oxytocin Treatment of Alcohol Dependence

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT02275611·13 enrolled

Schizophrenia2 trials

Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia

Terminated·NNational Institute of Mental Health (NIMH)·Phase 1/2·NCT01712646·18 enrolled

Oxytocin Treatment of Social Cognitive and Functional Deficits in Schizophrenia

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01394471·68 enrolled

Autism2 trials

Single Dose Intranasal Oxytocin and Cognitive Effects in Autism

Completed·UUniversity of Minnesota·Phase 2·NCT02493426·27 enrolled

Intranasal Oxytocin and Learning in Autism

Completed·RRobert Schultz·Phase 2·NCT01417026·36 enrolled

Tolerance1 trial

Does Oxytocin Alter Tolerance to or Motivation for Alcohol

Terminated·IIndiana University·Phase 2·NCT05312008·6 enrolled

Severe Mental Illness1 trial

Intranasal Oxytocin as Enhancer of Psychotherapy Outcomes in Severe Mental Illness

Active, not recruiting·SShalvata Mental Health Center·Phase 2·NCT03566069·120 enrolled

Anorexia Nervosa1 trial

The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa

Completed·UUniversity of Minnesota·Phase 1·NCT03414112·16 enrolled

Drug Dependence1 trial

Oxytocin and Cognitive Behavioral Therapy in Drug Dependence

Terminated·NNational Institute on Drug Abuse (NIDA)·Phase 4·NCT00975416·63 enrolled

Anxiety Disorder1 trial

Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders

Completed·MMassachusetts General Hospital·Phase 4·NCT01631682·186 enrolled

Intravenous1 trial

A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects

Completed·WWake Forest University Health Sciences·Phase 1·NCT05672667·25 enrolled

Breast Cancer1 trial

Pilot Study of Oxytocin and microRNA Identification in NAF, Serum, and Tissue in Women With Breast Cancer

Terminated·MMontefiore Medical Center·Phase 2·NCT02127073·8 enrolled

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1/2·NCT02548728·12 enrolled

Intranasal Administration1 trial

Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Healthy Adults

Completed·OOptiNose AS·Phase 1·NCT01983514·19 enrolled

Tic Disorder1 trial

Umbilical Cord Blood vs Personalized Treatments for Improving Autistic Disorder

Completed·FFundatia Bio-Forum·Phase 1·NCT04007224·35 enrolled

TIA1 trial

Common and Differentiated Representations Between Social Exclusion and Social Separation

Unknown status·UUniversity of Electronic Science and Technology of China·N/A·NCT05920707·120 enrolled

Efficacy1 trial

Evaluating the Efficacy of Intranasal Oxytocin Among Individuals With Persistent Pain

Completed·UUniversity of Calgary·Phase 2/3·NCT02888574·24 enrolled

Adolescent1 trial

Intranasal Oxytocin for the Treatment of Children and Adolescents With ASD (OXY)

Completed·EEvdokia Anagnostou·Phase 2·NCT01256060·15 enrolled

Cocaine-dependent1 trial

Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.

Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT02255357·43 enrolled

Borderline personality disorder1 trial

The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy Adults: A Pilot Behavioral Study

Suspended·IIcahn School of Medicine at Mount Sinai·Preclinical·NCT02225600·40 enrolled

Pain, Acute1 trial

Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain

Completed·WWake Forest University Health Sciences·Phase 2·NCT07053774·24 enrolled

Unspecified2 trials

Biological Basis of Individual Variation in Social Cooperation

Completed·EEmory University·N/A·NCT01566539·707 enrolled

The Biology of Resilience

Completed·HHarvard School of Public Health (HSPH)·N/A·NCT01011465·270 enrolled

Sources

References

[1]
ClinicalTrials.gov — 64 trial records for Intranasal oxytocin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Intranasal oxytocin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Intranasal oxytocin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Electronic Science and Technology of China company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: UUniversity of Electronic Science and Technology of China

Intranasal oxytocin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Oxytocin19 trials

Autism Spectrum Disorder7 trials

Prader-Willi syndrome3 trials

Alcohol Withdrawal3 trials

Frontotemporal Dementia2 trials

Social Behavior2 trials

Treatment2 trials

Alcohol Dependence2 trials

Schizophrenia2 trials

Autism2 trials

Tolerance1 trial

Severe Mental Illness1 trial

Anorexia Nervosa1 trial

Drug Dependence1 trial

Anxiety Disorder1 trial

Intravenous1 trial

Breast Cancer1 trial

Prolonged1 trial

Pain1 trial

Opioid Dependence1 trial

Intranasal Administration1 trial

Tic Disorder1 trial

TIA1 trial

Efficacy1 trial

Adolescent1 trial

Cocaine-dependent1 trial

Borderline personality disorder1 trial

Pain, Acute1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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