L-Arginine

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Heart FailureMyocardial InfarctionPeripheral Arterial DiseasePolycystic Ovarian SyndromeIntermittent ClaudicationCKD

206 competitors in Heart Failure

#DrugCompanyPhaseTrials

1

L-Arginine

Mario Negri Institute for Pharmacological Research

Phase 3

12

Bayer Aspirin

Bayer

Preclinical

23

Brethine

Sanofi

Preclinical

14

Medrol

Pfizer

Preclinical

15

Amidate

Pfizer

Preclinical

16

Activase

Roche

Preclinical

—7

Zemplar

AbbVie

Preclinical

—8

Adriamycin

Pfizer

Preclinical

—9

Savaysa

Daiichi Sankyo

Preclinical

—10

Xifaxan

SSalix

Preclinical

2Show 31 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

37 more indications

Postmenopausal Women1 trial

Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00001752·30 enrolled

Nitric Oxide1 trial

Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling

Completed·WWashington University School of Medicine·N/A·NCT00603720·54 enrolled

Rheumatoid Arthritis1 trial

Role of L-Arginine Supplementation in the Treatment of Rheumatoid Arthritis

Unknown status·RRenJi Hospital·Phase 2·NCT04535427·144 enrolled

Anemia1 trial

Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 1·NCT00056433·39 enrolled

Oral1 trial

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

Completed·CColgate Palmolive·Phase 1·NCT06182267·29 enrolled

Pulmonary Hypertension1 trial

L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

Unknown status·SSherief Abd-Elsalam·Phase 4·NCT03402191·60 enrolled

Vasoconstriction1 trial

The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction

Completed·TThe University of Texas at Arlington·Phase 1·NCT03679780·19 enrolled

High Risk1 trial

Efficacy of Aspirin and L-arginine in High Risk Preeclamptic

Suspended·UUniversity of Guadalajara·Phase 2·NCT02838030·82 enrolled

Intermittent Claudication1 trial

The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication

Recruiting·LLouis Messina·Phase 1·NCT04800692·10 enrolled

Preeclampsia1 trial

L-Arginine in Pre-Eclampsia

Completed·Mario Negri Institute for Pharmacological Research·Phase 3·NCT00157521·30 enrolled

Prevention1 trial

Prevention of Cardiac and Vascular Events in Patients With NGT/IGT.

Completed·IIRCCS San Raffaele·Phase 3·NCT00408577·150 enrolled

Alzheimer's Disease1 trial

Endothelial Facilitation in Alzheimer's Disease

Completed·UUniversity of Massachusetts, Worcester·Phase 2·NCT01439555·11 enrolled

Essential Hypertension1 trial

L-Arginine Metabolism in Essential Hypertension

Completed·UUniversity of Erlangen-Nürnberg Medical School·Phase 2/3·NCT00137124·120 enrolled

Pulmonary Tuberculosis1 trial

L-arginine and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis (TB)

Completed·MMenzies School of Health Research·Phase 3·NCT00677339·200 enrolled

Vasodilation1 trial

L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome

Completed·TThe Hospital for Sick Children·Phase 2·NCT01603446·7 enrolled

Myocardial Infarction1 trial

Vascular Interaction With Age in Myocardial Infarction

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·N/A·NCT00051376

ISS1 trial

L-arginine and Brown Adipose Tissue

Unknown status·MMaastricht University Medical Center·Phase 3·NCT02291458·26 enrolled

Duchenne Muscular Dystrophy1 trial

Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin

Completed·UUniversity Hospital, Basel, Switzerland·Phase 1·NCT02516085·5 enrolled

Type 2 Diabetes Mellitus1 trial

Prevention of Type 2 Diabetes Mellitus by L-Arginine in Patients With Metabolic Syndrome

Completed·IIRCCS San Raffaele·Phase 3·NCT00917449·142 enrolled

Humans1 trial

Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans

Completed·UUniversity Hospital, Strasbourg, France·Phase 4·NCT02117206·60 enrolled

Heart Failure1 trial

Effect of Add-on L-Arginine Therapy on Heart Failure Patients

Not yet recruiting·GGerman University in Cairo·Phase 2·NCT07394270·200 enrolled

Randomized1 trial

L-Arginine Role for Stone Lower Ureter : A Randomized Control Study

Completed·SSohag University·Phase 4·NCT06753526·153 enrolled

Prostate Cancer1 trial

L-Arginine Supplementation With or Without Enzyme Inhibitors Treating Erectile Function of Prostate Cancer Survivors

Completed·WWake Forest University Health Sciences·Phase 2·NCT01105130·140 enrolled

Diabetic Foot1 trial

Immunonutrition for Diabetic Foot Ulcers

Terminated·PPrisma Health-Midlands·Phase 2/3·NCT05281562·1 enrolled

Smokers1 trial

The Effect of Orally Administered L- Arginine on Quadriceps Strenght in Healthy Smokers

Unknown status·GGoranka Radmilović·Phase 4·NCT04643600·163 enrolled

Oligohydramnios1 trial

Comparison Between Treatments of Oligohydramnios

Recruiting·KKafrelsheikh University·Phase 2·NCT07135037·40 enrolled

Endothelial Function1 trial

Endothelial Function in Human Arteries

Completed·TThe Cleveland Clinic·Phase 1·NCT00848302·25 enrolled

Peripheral Arterial Disease1 trial

L-Arginine in the Treatment of Peripheral Arterial Disease

Completed·SStanford University·N/A·NCT00284076

Pre-Term1 trial

Effect of L-arginine and Glutamine on Preterm

Completed·—·Phase 2/3·NCT01263041·75 enrolled

Critically Ill Patients1 trial

Directed Immuno Nutrition by L-arginine for Critically Ill Patients

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT01038622·30 enrolled

Corticosteroids1 trial

Safety, Tolerability and Effects of L-Arginine in Boys With Dystrophinopathy on Corticosteroids

Completed·MMassachusetts General Hospital·Phase 1·NCT01388764·7 enrolled

Cystic Fibrosis1 trial

The Short Term Safety and Efficacy of Inhaled L-arginine in Patients With Cystic Fibrosis

Completed·TThe Hospital for Sick Children·Phase 2·NCT00405665·20 enrolled

Prospective1 trial

Prospective L-arginine Study

Terminated·UUniversity of Michigan·Phase 1·NCT01485757·3 enrolled

Polycystic Ovarian Syndrome1 trial

Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients

Not yet recruiting·—·Phase 3·NCT06405243·100 enrolled

CKD1 trial

L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients

Recruiting·TThe University of Texas at Arlington·Phase 4·NCT03982160·15 enrolled

Acute Kidney Injury1 trial

Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery: a Target Trial Emulation

Not yet recruiting·XXijing Hospital··NCT07718373·5,000 enrolled

Unspecified1 trial

Effect of the Administration of L-arginine vs. Placebo in Patients Diagnosed With Presbyvestibulopathy.

Withdrawn·CCentro Universitario de Tonalá·Phase 2·NCT05932979

Details

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