Ozone

Phase 3Small molecule

TTanta University

Ozone is one of 147 small molecule programs targeting Myofascial Pain Syndrome. It is currently in Phase 3.

Indications

Total Trials

Active Trials

146

Competitors

Pipeline

Status by Indication[3][1]

Indication

Myofascial Pain SyndromeActive, not recruiting

Neck PainActive, not recruiting

Carpal Tunnel SyndromeActive, not recruiting

Periodontal DisorderActive, not recruiting

BronchitisActive, not recruiting

Chronic PainActive, not recruiting

AsthmaActive, not recruiting

Greater Trochanteric Pain SyndromeCompleted

Diabetic NeuropathyActive, not recruiting

Myofascial Pain SyndromePreclinical

Active, not recruiting

Neck PainPreclinical

Active, not recruiting

Carpal Tunnel SyndromePreclinical

Active, not recruiting

Periodontal DisorderPreclinical

Active, not recruiting

BronchitisPreclinical

Active, not recruiting

Chronic PainPreclinical

Active, not recruiting

AsthmaPreclinical

Active, not recruiting

Greater Trochanteric Pain SyndromePreclinical

Completed

Diabetic NeuropathyPreclinical

Active, not recruiting

Competition

Competitive Landscape

161 competitors in Asthma

#DrugCompanyPhaseTrials

Ozone

TTanta University

Phase 3

1 2

Celexa

AbbVie

Preclinical

1 3

Arcoxia

Novartis

Preclinical

—4

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Preclinical

1 5

Blood Withdrawn

Emergent BioSolutions

Preclinical

1 6

DUPIXENT

Regeneron

Preclinical

1 7

Paracetamol

GSK

Preclinical

1 8

Aclidinium Bromide

Atrovent

2 10

Lexapro

SShirley Ryan AbilityLab

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

PreclinicalRecruiting

Chemotherapy-Induced Peripheral Neuropathy

NCT04299893

Q2 2028

Phase 1Recruiting

Lung Inflammation

NCT05773001

Clinical

Trials by Indication[1]

Ozone3 trials

Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis

Completed·—·Phase 1·NCT03646877·22 enrolled

ONES Grant: CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability

Completed·—·Phase 1·NCT03599206·14 enrolled

Ozone Therapy in Endodontic Practice, in Vivo Study

Completed·UUniversity of Sao Paulo·Phase 2·NCT00946634·60 enrolled

Osteoarthritis2 trials

Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis

Completed·TTanta University·N/A·NCT06909305·60 enrolled

Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid

Unknown status·HHumanitas Clinical and Research Center·Phase 3·NCT04426721·120 enrolled

Carpal Tunnel Syndrome2 trials

Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief

Recruiting·TTanta University·N/A·NCT06133712·135 enrolled

Local Injection of Ozone Versus Methylprednisolone Acetate in Carpal Tunnel Syndrome of Scleroderma Patients

Completed·—·N/A·NCT03742466·50 enrolled

Complication2 trials

Efficacy of Ozone Therapy in Reducing Complications Following Impacted Mandibular Third-molar Surgery

Recruiting·JJelena Krunic·Phase 3·NCT06802354·20 enrolled

Effect of LLLT and Ozone to Reduce Complications After Extraction of Impacted Lower Molar

Completed·UUniversity of Baghdad·N/A·NCT05922150·60 enrolled

Efficacy2 trials

Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT03395119·44 enrolled

Efficacy of Ozone Gel, Doxycycline Saturated Chitosan Dressing Versus Alveogyl

Completed·MMinia University·N/A·NCT05875506·60 enrolled

12 more indications

Periodontitis2 trials

Ozone Gel Application in Controlled Type 2 Diabetic Patients With Periodontitis

Unknown status·—·N/A·NCT05538078·24 enrolled

Use of Ozone Gel as an Antimicrobial in Treatment of Periodontitis

Completed·GGhufran Falih Hassan·Phase 1·NCT05905445·21 enrolled

Hernia1 trial

Clinical Effects of Ozone Therapy in Cervical Disc Hernia

Unknown status·SSakarya University··NCT03056911·43 enrolled

Heart Disease1 trial

Ozone Therapy in Refractory Ischemic Heart Disease.

Terminated·—·Phase 2/3·NCT03660657·1 enrolled

Cardiac Surgery1 trial

The Cardioprotective Effects of Adding Ozone To Cardioplegic Solution in Adult Cardiac Surgery

Unknown status·—·Phase 2/3·NCT03876067·40 enrolled

Asthma1 trial

Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers

Completed·UUniversity of North Carolina, Chapel Hill·N/A·NCT00287365·25 enrolled

Myofascial Pain Syndrome1 trial

Efficacy of Local Anesthetic and Ozone Injection in Patients With Myofascial Pain Syndrome

Unknown status·PPamukkale University·N/A·NCT05318560·72 enrolled

Lung Inflammation1 trial

Macrophage Regulation of Ozone-Induced Lung Inflammation

Recruiting·—·Phase 1·NCT05773001·100 enrolled

Diabetic Neuropathy1 trial

Ozone Therapy in Patients With Diabetic Neuropathy

Unknown status·—·N/A·NCT05000463·60 enrolled

Sepsis1 trial

Methylene Blue and Ozone in Early Sepsis

Unknown status·—·Phase 4·NCT02910765·40 enrolled

Greater Trochanteric Pain Syndrome1 trial

Comparison of Ozone and Steroid Injection in Patients With Greater Trochanteric Pain Syndrome

Completed·SSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey·N/A·NCT04420572·63 enrolled

Interstitial Cystitis1 trial

Evaluation of Response to Use of Intravesical Ozone Gas in Interstitial Cystitis /Bladder Pain Syndrome

Unknown status·—·Phase 2·NCT04789135·50 enrolled

Chemotherapy-induced Peripheral Neuropathy1 trial

Effectiveness and Cost-effectiveness of Ozone Therapy in Patients With Pain Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (O3NPIQ)

Recruiting·BBernardino Clavo, MD, PhD·Preclinical·NCT04299893·42 enrolled

Sources

References

[1]
ClinicalTrials.gov — 24 trial records for Ozone. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ozone compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ozone. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Tanta University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TTanta University

Ozone

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q2 2028

Trials by Indication[1]

Ozone3 trials

Osteoarthritis2 trials

Carpal Tunnel Syndrome2 trials

Complication2 trials

Efficacy2 trials

Periodontitis2 trials

Hernia1 trial

Heart Disease1 trial

Cardiac Surgery1 trial

Asthma1 trial

Myofascial Pain Syndrome1 trial

Lung Inflammation1 trial

Diabetic Neuropathy1 trial

Sepsis1 trial

Greater Trochanteric Pain Syndrome1 trial

Interstitial Cystitis1 trial

Chemotherapy-induced Peripheral Neuropathy1 trial

References

Drug Info

Quick Facts

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