Esmeron

(Rocuronium bromide)

PreclinicalSmall molecule

Rocuronium bromide is a muscle relaxant used during surgery and anesthesia to paralyze muscles so doctors can perform procedures more easily and safely.[1] Esmeron is currently being investigated across 3 indications[3], with its most advanced program in Preclinical.[1]

Esmeron is one of 55 small molecule programs targeting Bladder Tumor. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Bladder TumorActive, not recruiting

Nerve BlockCompleted

Morbid ObesityActive, not recruiting

Bladder TumorPreclinical

Active, not recruiting

Nerve BlockPreclinical

Completed

Morbid ObesityPreclinical

Active, not recruiting

Competition

Competitive Landscape

49 competitors in Morbid Obesity

#DrugCompanyPhaseTrials

Ozempic

Novo Nordisk

Approved

6 2

Lovenox

Sanofi

Approved

1 3

Mounjaro

Eli Lilly

Approved

—4

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

1 5

Prilosec

DDexcel Pharma Technologies Ltd.

Approved

1 6

Amoxil

GGlobal Antibiotics Research and Development Partnership

Xylocaine

Arixtra

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

—9

Imcivree

Rhythm Pharmaceuticals

Marcaine

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2028

Post-ApprovalNot yet recruiting

Neuromuscular Blockade

NCT07044193

Post-ApprovalActive, not recruiting

Neuromuscular Blockade

NCT07044180

Clinical

Trials by Indication[1]

Rocuronium4 trials

Pharmacokinetic and Pharmacodynamic of Rocuronium

Completed·PPontificia Universidad Catolica de Chile··NCT02376595·10 enrolled

Evaluation of Intubation Conditions Following BX1000 or Rocuronium in Subjects Undergoing Surgery

Completed·BBaudax Bio·Phase 2·NCT05687253·80 enrolled

Continuous Infusion Versus Intermittent Bolus Injection of Rocuronium

Unknown status·SSeoul National University Hospital·Phase 4·NCT03060707·70 enrolled

Show 1 more trial

Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft

Unknown status·SSeoul National University Hospital·N/A·NCT02827435·12 enrolled

General Anesthesia3 trials

Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle Relaxants

Recruiting·UUniversity Hospital of Split·Phase 4·NCT06399445·60 enrolled

A Study to Compare Different Intubating Doses of Zemuron in Pediatric and Adolescent Subjects Under General Anesthesia

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00124722·207 enrolled

Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction

Completed·GGeneral Hospital of Ningxia Medical University·Preclinical·NCT07716891·121 enrolled

Neuromuscular Blockade3 trials

Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia

Not yet recruiting·TTamas Vegh, MD·Phase 4·NCT07044193·80 enrolled

Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Propofol Anesthesia

Active, not recruiting·TTamas Vegh, MD·Phase 4·NCT07044180·80 enrolled

Partial Neuromuscular Blockade for Lung Protective Mechanical Ventilation

Unknown status·AAmsterdam UMC, location VUmc·Phase 4·NCT03646266·30 enrolled

Anesthesia1 trial

Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia

Completed·—·Phase 1·NCT05097508·40 enrolled

Lumbar Erector Spinae Plane Block1 trial

Lumbar Erector Spinae Plane Block for Back Surgery

Unknown status·DDr M. B. Breebaart·Phase 3·NCT03825198·80 enrolled

14 more indications

Intravenous1 trial

Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00988520·38 enrolled

Efficacy and Safety1 trial

Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia

Completed·RR-Pharm·Phase 3·NCT03669484·150 enrolled

Hip Replacement Surgery1 trial

Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function

Completed·RRadboud University Medical Center·Phase 4·NCT05562999·100 enrolled

Laparoscopic Cholecystectomy1 trial

Deep vs Moderate Neuromuscular Blockade in Day Case Laparoscopic Cholecystectomy.

Completed·WWahba bakhet·Phase 4·NCT03881423·80 enrolled

Neuromuscular Block1 trial

Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application

Unknown status·TTC Erciyes University·N/A·NCT03424356·96 enrolled

Depth of Anesthesia1 trial

Evaluation of EEG With Respect to the Change of Depth of Anesthesia During General Anesthesia

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02586441·40 enrolled

Infiltration1 trial

Effect of Paravertebral Muscle Fat Infiltration on Rocuronium Use in Lumbar Surgery

Completed·ZZheng Guo·Phase 1·NCT05619848·87 enrolled

Efficacy1 trial

Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00984633·40 enrolled

Laparoscopy1 trial

Deep NMB in Ambulatory Gynecological Laparoscopy

Completed·WWahba bakhet·Phase 4·NCT04105764·80 enrolled

Quality of Recovery1 trial

The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Early Quality of Recovery

Completed·RRadboud University Medical Center·Phase 4·NCT03608436·178 enrolled

Sugammadex1 trial

Dose-Finding Pediatric and Adult Trial With Sugammadex (Org 25969, MK-8616, SCH 900616) (19.4.306) (MK-8616-034) (P05961)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00421148·94 enrolled

Nerve Block1 trial

Current Intensity for the Obturator Nerve Block

Completed·—·N/A·NCT05872451·30 enrolled

Colorectal Surgery1 trial

The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.

Completed·RRadboud University Medical Center·Phase 4·NCT03572413·100 enrolled

Unspecified1 trial

Electromyographic (EMG) on the Anaesthesia Monitor

Completed·TTampere University Hospital·Phase 4·NCT01142635·30 enrolled

Sources

References

[1]
ClinicalTrials.gov — 26 trial records for Rocuronium bromide. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Rocuronium bromide compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Rocuronium bromide. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Muscle-Type Nicotinic Acetylcholine Receptor Antagonist[2]
Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: Merck & Co.

Esmeron

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2028

Trials by Indication[1]

Rocuronium4 trials

General Anesthesia3 trials

Neuromuscular Blockade3 trials

Anesthesia1 trial

Lumbar Erector Spinae Plane Block1 trial

Intravenous1 trial

Efficacy and Safety1 trial

Hip Replacement Surgery1 trial

Laparoscopic Cholecystectomy1 trial

Neuromuscular Block1 trial

Depth of Anesthesia1 trial

Infiltration1 trial

Efficacy1 trial

Laparoscopy1 trial

Quality of Recovery1 trial

Sugammadex1 trial

Nerve Block1 trial

Colorectal Surgery1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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