Explore

Companies

Drugs

About·Data Management·Terms·Privacy

Stay informed

© 2026 VivoSeq. All rights reserved.

Disalcid

(Salsalate)

Phase 2Small molecule

JJoslin Diabetes Center

Salsalate is used to reduce pain, fever, and inflammation caused by conditions like arthritis and other joint diseases. It works similarly to aspirin but is gentler on the stomach.[1] Disalcid is currently being investigated across 7 indications[3], with its most advanced program in Phase 2.[1]

Disalcid is one of 144 small molecule programs targeting Rheumatoid Arthritis. It is currently in Phase 2.

7

Indications

30

Total Trials

2

Active Trials

143

Competitors

Pipeline

Status by Indication[3][1]

Indication

Rheumatoid ArthritisUnknown

Spinal Cord InjuryActive, not recruiting

HypertensionActive, not recruiting

Peripheral NeuropathyRecruiting

E-Cigarette UseRecruiting

Rheumatoid ArthritisPreclinical

Unknown

Spinal Cord InjuryPreclinical

Active, not recruiting

HypertensionPreclinical

Active, not recruiting

Peripheral NeuropathyPhase 2

Recruiting

E-Cigarette UsePhase 1

Recruiting

Competition

Competitive Landscape

181 competitors in Rheumatoid Arthritis

#DrugCompanyPhaseTrials

Disalcid

JJoslin Diabetes Center

Actos

Celexa

Voltaren

Cataflam

Plaquenil

Jazz Pharmaceuticals

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Velcade

SShilpa Grover, MD, MPH

Vancocin

HHikma Pharmaceuticals LLC

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Recruiting

E-Cigarette Use

NCT06489249

Q3 2027

Phase 1/2Recruiting

Peripheral Neuropathy

NCT05169060

Clinical

Trials by Indication[1]

Insulin resistance4 trials

Salsalate for Insulin Resistance in Schizophrenia

Completed·UUniversity of Maryland, Baltimore·N/A·NCT01182727·13 enrolled

Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk

Completed·VVA Office of Research and Development·Phase 2/3·NCT00330733·71 enrolled

The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 4·NCT00339833·54 enrolled

Show 1 more trial

Effect of Salicylate on Glucose Metabolism in Insulin Resistance States

Completed·JJoslin Diabetes Center·Phase 1/2·NCT00258128·17 enrolled

Peripheral Neuropathy2 trials

Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy

Recruiting·UUniversity of Iowa·Phase 1/2·NCT05169060·100 enrolled

Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy

Completed·UUniversity of Michigan·Phase 2·NCT01480297·8 enrolled

Polycystic Ovary Syndrome2 trials

Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction

Completed·UUniversity of Illinois at Chicago·Phase 2·NCT03229408·60 enrolled

Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS)

Terminated·IIndiana University·Phase 1·NCT01489319·47 enrolled

Type 2 Diabetes2 trials

Targeting INflammation Using SALsalate in Type 2 Diabetes (TINSAL-T2D)

Completed·JJoslin Diabetes Center·Phase 2/3·NCT00392678·277 enrolled

Targeting Inflammation Using Salsalate for Type 2 Diabetes-Stage II

Completed·JJoslin Diabetes Center·Phase 2/3·NCT00799643·638 enrolled

Inflammation2 trials

The Study of Inflammation on Blood Glucose Levels in Obese People

Completed·JJoslin Diabetes Center·Phase 2·NCT00258115·20 enrolled

Inflammation Inhibition in Prediabetic Humans

Terminated·GGary L. Pierce·Phase 2·NCT01977417·21 enrolled

18 more indications

Schizophrenia1 trial

Salsalate as an Adjunctive Treatment for Patients With Schizophrenia

Completed·UUniversity of Massachusetts, Worcester·Phase 4·NCT01578486·17 enrolled

Type 1 Diabetes1 trial

Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy

Completed·UUniversity of Michigan·Phase 2/3·NCT02936843·61 enrolled

CLE1 trial

Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?

Completed·SStanford University·N/A·NCT02007577·41 enrolled

Acute Myeloid Leukemia1 trial

Salsalate, Venetoclax, and Decitabine or Azacitidine for the Treatment of Acute Myeloid Leukemia or Advanced Myelodysplasia/Myeloproliferative Disease

Completed·RRutgers, The State University of New Jersey·Phase 2·NCT04146038·5 enrolled

Mild to Moderate Alzheimer's Disease1 trial

Salsalate in Patients Mild to Moderate Alzheimer's Disease

Completed·AAdam Boxer·Phase 1·NCT03277573·40 enrolled

Endothelial Dysfunction1 trial

Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 2·NCT01046682·40 enrolled

Infiltration1 trial

Using Salsalate to Target Adipocyte Macrophage Infiltration

Completed·UUniversity of Southern California·Phase 1·NCT02130804·30 enrolled

Preeclampsia1 trial

Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia

Completed·UUniversity of Iowa·Phase 1·NCT03482440·24 enrolled

E-cigarette Use1 trial

Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

Recruiting·UUniversity of Iowa·Phase 1·NCT06489249·24 enrolled

Cardiac Surgery1 trial

Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control

Withdrawn·MMcMaster University·Phase 1·NCT03816488

Atherosclerosis1 trial

Inflammation and Vascular Function in Atherosclerosis

Completed·—·Phase 2/3·NCT00760019·58 enrolled

Cardiovascular Disease1 trial

Targeting Inflammation Using Salsalate in CardioVascular Disease

Completed·JJoslin Diabetes Center·Phase 2/3·NCT00624923·340 enrolled

Alcoholic Fatty Liver Disease1 trial

The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Disease

Completed·KKorea University Guro Hospital·Phase 4·NCT03222206·34 enrolled

Progressive Supranuclear Palsy1 trial

A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy

Completed·AAdam Boxer·Phase 1·NCT02422485·10 enrolled

Cardiovascular1 trial

Targeting Inflammation to Treat Cardiovascular Aging

Completed·GGary L. Pierce·Phase 2·NCT01775865·59 enrolled

Hypertension1 trial

Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)

Completed·EEmory University·N/A·NCT02406586·36 enrolled

Vascular Dysfunction1 trial

Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction

Completed·—·Phase 1·NCT00553995·60 enrolled

Anemia1 trial

Trial To Evaluate the Efficacy of Oral Salsalate in the Treatment of Older Adults With Unexplained Anemia

Terminated·HHarvey Jay Cohen·Phase 2·NCT01506726·11 enrolled

Sources

References

[1]
ClinicalTrials.gov — 30 trial records for Salsalate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Salsalate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Salsalate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Joslin Diabetes Center company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: JJoslin Diabetes Center

Related News