acetylsalicylic acid

ApprovedSmall molecule

Bayer

acetylsalicylic acid is one of 1059 small molecule programs targeting Insulin resistance. It is currently in Approved.

Indications

143

Total Trials

Active Trials

1,058

Competitors

Pipeline

Status by Indication[3][1]

Indication

Insulin ResistanceActive, not recruiting

HIV InfectionActive, not recruiting

Transient Ischemic AttackActive, not recruiting

Respiratory Tract InfectionActive, not recruiting

Low Back PainActive, not recruiting

Esophageal CarcinomaActive, not recruiting

Oral LeukoplakiaActive, not recruiting

Retinal Artery OcclusionActive, not recruiting

Common ColdActive, not recruiting

Hip FractureActive, not recruiting

Insulin ResistanceApproved

Active, not recruiting

HIV InfectionPreclinical

Active, not recruiting

Transient Ischemic AttackPhase 2

Active, not recruiting

Respiratory Tract InfectionApproved

Active, not recruiting

Low Back PainPhase 3

Active, not recruiting

Esophageal CarcinomaPhase 1

Active, not recruiting

Oral LeukoplakiaPhase 1

Active, not recruiting

Retinal Artery OcclusionPhase 3

Active, not recruiting

Common ColdApproved

Active, not recruiting

Hip FracturePhase 2

Active, not recruiting

Showing 10 of 44 indications

Competition

Competitive Landscape

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

acetylsalicylic acid

Bayer

Approved

2 2

COVID-19 Vaccine

Moderna

Preclinical

27 3

Proventil

Mylan Pharmaceuticals Inc

Preclinical

1 4

SARS-COV-2 VACCINE

Moderna

Preclinical

2 5

Statin

Bristol-Myers Squibb

Preclinical

1 6

Interferon-Gamma

SSPP Pharmaclon Ltd.

Preclinical

1 7

Antihypertensive Agents

NNational Heart, Lung, and Blood Institute (NHLBI)

Preclinical

1 8

Exoflo

DDirect Biologics, LLC

Preclinical

3 9

Other Tkis

Bayer

Preclinical

1 10

Covid Infection

KKing's College London

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 3Active, not recruiting

Colorectal Cancer

NCT02647099

Phase 2Active, not recruiting

Ovarian Cancer

NCT03480776

Q4 2026

Phase 3Recruiting

Anticoagulation

NCT05035277

Phase 2Active, not recruiting

Screening

NCT03654105

Phase 3Recruiting

CABG

NCT03789916

N/ARecruiting

Chronic Kidney Disease

NCT04330729

Clinical

Trials by Indication[1]

Aspirin8 trials

Aspirin in Reduction of Tension II Study

Completed·LLeiden University Medical Center·Phase 4·NCT01379079·290 enrolled

ASPIRIN Trial Belgium

Active, not recruiting·UUniversity Hospital, Antwerp·Phase 3·NCT03464305·148 enrolled

A Study to Assess Disintegration of the New Aspirin Disintegrating Tablets

Completed· Bayer logo

Bayer·Phase 1·NCT03225352·12 enrolled

Show 5 more trials

Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU

Completed· Bayer logo

Bayer··NCT03904732·2,000,000 enrolled

Pharmacokinetic Study Comparing Aspirin and Aspirin Granules

Completed· Bayer logo

Bayer·Phase 1·NCT01072604·30 enrolled

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Completed· Bayer logo

Bayer··NCT02550717·398,158 enrolled

Pharmacokinetic Study Comparing Aspirin and Effervescent Aspirin

Completed· Bayer logo

Bayer·Phase 1·NCT01081353·26 enrolled

Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial.

Completed·—·Phase 2·NCT02280031·50 enrolled

Colorectal Cancer7 trials

Aspirin in Preventing Colorectal Cancer in Patients at Increased Risk of Colorectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00468910·79 enrolled

Aspirin in Colorectal Cancer Liver Metastases

Active, not recruiting·OOslo University Hospital·Phase 2/3·NCT03326791·466 enrolled

Acetylsalicylic Acid and Colorectal Cancer Prevention: Exploring the Platelet Function of Its Mechanism of Action

Unknown status·—·Phase 3·NCT02125409·40 enrolled

Show 4 more trials

The Colorectal Cancer Chemoprevention Acceleration and Improvement Platform (CRC-CHAMP) Study

Unknown status·UUniversity of Calgary·Phase 2·NCT05402124·100 enrolled

Assessment of Direct Biomarkers of Aspirin Action to Develop a Precision Chemoprevention Therapy of Colorectal Cancer

Recruiting·IInstituto de Investigación Sanitaria Aragón·Phase 2·NCT03957902·60 enrolled

Aspirin for Dukes C and High Risk Dukes B Colorectal Cancers

Unknown status·NNational Cancer Centre, Singapore·Phase 3·NCT00565708·1,587 enrolled

Adjuvant Low Dose Aspirin in Colorectal Cancer

Active, not recruiting·AAnna Martling·Phase 3·NCT02647099·626 enrolled

Atrial Fibrillation6 trials

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 4·NCT02415400·4,614 enrolled

NOACs for Stroke Prevention in Patients With Atrial Fibrillation and Previous ICH

Completed·PPopulation Health Research Institute·Phase 2·NCT02998905·30 enrolled

A Phase III Study of Apixaban in Patients With Atrial Fibrillation

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT00496769·6,421 enrolled

Show 3 more trials

Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial

Completed·OOttawa Heart Institute Research Corporation·Phase 4·NCT02168829·1,284 enrolled

Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease

Completed·—·Phase 4·NCT02982850·120 enrolled

Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy

Completed·—·Phase 4·NCT03463317·912 enrolled

Preeclampsia5 trials

Low Doses of Aspirin in the Prevention of Preeclampsia

Completed·WWeill Medical College of Cornell University·Phase 3·NCT04070573·400 enrolled

Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia

Completed·—·Phase 4·NCT01352234·104 enrolled

Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial

Unknown status·—·N/A·NCT05580523·3,000 enrolled

Show 2 more trials

Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia

Completed·JJohn O'Brien, MD·Phase 2·NCT03893630·208 enrolled

Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes.

Terminated·IInstituto de Investigacion Sanitaria La Fe·Phase 3·NCT02174328·81 enrolled

Acute Coronary Syndrome5 trials

Study to Assess Safety and Efficacy of Ticagrelor (AZD6140) Versus Clopidogrel in Asian/Japanese Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT01294462·801 enrolled

Antithrombotic Therapy in Acute Coronary Syndromes and Coronary Artery Ectasia

Unknown status·IInstituto Nacional de Cardiologia Ignacio Chavez·Phase 2·NCT05233124·60 enrolled

BAY81-8781, I.V. Aspirin in the Indication of Acute Coronary Syndrome (ACS)

Completed· Bayer logo

Bayer·Phase 3·NCT00910065·270 enrolled

Show 2 more trials

Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 4·NCT04057300·1,038 enrolled

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT02293395·3,037 enrolled

89 more indications

Ischemic stroke4 trials

ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion

Active, not recruiting·FFundación Pública Andaluza para la gestión de la Investigación en Sevilla·Phase 4·NCT05225961·240 enrolled

Early Administration of Aspirin in Patients With Acute Ischemic Stroke Treated With Systemic Thrombolysis

Unknown status·—·N/A·NCT02921360·120 enrolled

Ginkgo Diterpene Lactone Meglumine Injection on Platelet Reactivity in Acute Ischemic Stroke

Unknown status·RRenJi Hospital·Phase 2/3·NCT03219645·40 enrolled

Show 1 more trial

Antiplatelet Effect of Ginkgo Diterpene Lactone Meglumine Injection in Acute Ischemic Stroke

Unknown status·SShanghai Yueyang Integrated Medicine Hospital·Phase 2/3·NCT05531942·70 enrolled

Stroke3 trials

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Terminated· Bayer logo

Bayer·Phase 3·NCT02313909·7,213 enrolled

[SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES]

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT01994720·13,307 enrolled

A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke

Completed· Ipsen logo

Ipsen·Phase 3·NCT00276380·204 enrolled

Prevention3 trials

PREVENTion of Clot in Orthopaedic Trauma

Completed·MMajor Extremity Trauma Research Consortium·Phase 3·NCT02984384·12,424 enrolled

Study to Gather Information to What Extent Patients Follow the Treatment Regimen of Low-dose Aspirin for Primary and Secondary Prevention of Diseases of the Heart and Blood Vessels

Completed· Bayer logo

Bayer··NCT04097912·99,999 enrolled

Study to Evaluate How Patients Regard the Benefits and Risks of Low-dose Aspirin for the Prevention of Heart and Blood Vessels Disease and for the Prevention of Cancer of the Colon and Rectum

Completed· Bayer logo

Bayer··NCT03603366·1,028 enrolled

Antiplatelet3 trials

Study of Biochemical Markers to Determine the Acetylsalicylic Acid Chemopreventive Effect Through Antiplatelet Action

Completed·—·Phase 1·NCT02060396·24 enrolled

Antiplatelet Strategy for Peripheral Arterial Interventions for Revascularization of Lower Extremities

Completed·UUniversity of Texas Southwestern Medical Center·Phase 3·NCT02217501·159 enrolled

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)

Completed·EECRI bv·Phase 3·NCT02833948·231 enrolled

Common Cold3 trials

Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold

Completed· Bayer logo

Bayer·Phase 4·NCT01465009·508 enrolled

Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold

Completed· Bayer logo

Bayer·Phase 3·NCT01361399·1,088 enrolled

Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold

Completed· Bayer logo

Bayer·Phase 3·NCT00963443·833 enrolled

Prostate Cancer2 trials

Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer

Recruiting·GGustave Roussy, Cancer Campus, Grand Paris·Phase 3·NCT03819101·1,210 enrolled

Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse

Completed·UUNICANCER·Phase 3·NCT00055731·413 enrolled

Hematoma2 trials

Influence of Acetylsalicylic Acid and Low Molecular Weight Heparins on the Incidence of Renal Hematoma of Shockwave Lithotripsy

Completed·KKantonsspital Winterthur KSW··NCT02875717·500 enrolled

Chronic Subdural Hematoma and Aspirin

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT03120182·150 enrolled

Coronary Artery Bypass2 trials

ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery

Unknown status·RRigshospitalet, Denmark·Phase 3·NCT01046942·250 enrolled

Optimal Dose of Acetylsalicylic Acid After Coronary Artery Bypass Grafting

Completed·KKarolinska University Hospital·Phase 2/3·NCT02482857·45 enrolled

COVID-192 trials

Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19

Completed·UUniversity of Milan·Phase 2·NCT04368377·5 enrolled

Hemostasis in COVID-19: an Adaptive Clinical Trial

Unknown status·UUniversity of Sao Paulo General Hospital·Phase 2·NCT04466670·379 enrolled

Resistance2 trials

Laboratory Aspirin Resistance in Diabetics and Non-Diabetics

Completed·UUniversity of Aarhus·N/A·NCT00563875·210 enrolled

The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults

Completed·KKarolinska Institutet·Phase 2·NCT02531451·34 enrolled

Esophageal Cancer2 trials

Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00474903·122 enrolled

Low-dose Aspirin Therapy for Esophageal Cancer

Withdrawn·ZZhejiang University·Phase 3·NCT02326779

Treatment2 trials

Use of 81 vs 325mg of ASA in Treatment of BCVI

Not yet recruiting·LLondon Health Sciences Centre·Phase 1·NCT06383650·40 enrolled

A Study to Collect Data on the Treatment Pattern of Xarelto + Acetylsalicylic Acid in the Routine Clinical Practice in Patients Who Are Suffering From a Condition That Narrows the Blood Vessels Supplying the Heart and / or a Condition That Most Commonly Narrows the Blood Vessel in the Legs

Completed· Bayer logo

Bayer··NCT04401761·3,189 enrolled

Headache2 trials

Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache

Terminated· Bayer logo

Bayer·Phase 3·NCT01552798·9 enrolled

Efficacy and Tolerability of Metamizol in Patients With Episodic Moderate Headache

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT02183220·417 enrolled

Effectiveness2 trials

Study to Learn More About the Safety and Effectiveness of Rivaroxaban (Xarelto) When Given Together With Acetylsalicylic Acid to Indian People With Narrowing of the Arteries of the Heart (CAD) and/or With Reduced Blood Flow in the Arteries of the Legs and Arms With Symptoms (Symptomatic PAD)

Completed· Bayer logo

Bayer··NCT04298567·300 enrolled

Effectiveness of Low Dose Aspirin in Decreasing the Chance Getting Stomach and Intestine Cancer

Completed· Bayer logo

Bayer··NCT04081831·99,999 enrolled

Ovarian Cancer2 trials

Anti-programmed Cell Death-1 Ligand 1 (aPDL-1) Antibody Atezolizumab, Bevacizumab and Acetylsalicylic Acid in Recurrent Platinum Resistant Ovarian Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT02659384·122 enrolled

ASA in Prevention of Ovarian Cancer (STICs and STONEs)

Active, not recruiting·CCanadian Cancer Trials Group·Phase 2·NCT03480776·117 enrolled

Diabetic Nephropathy1 trial

Study of the Protective Effect of Low-dose Aspirin on Renal Function in Patients With Early Diabetic Nephropathy

Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 2/3·NCT06068439·355 enrolled

Injury1 trial

A Project to Improve the Diagnosis and Prognosis of Myocardial Injury Associated to Non Cardiac Surgery

Completed·PParc de Salut Mar··NCT03133260·800 enrolled

High Risk1 trial

Efficacy of Aspirin and L-arginine in High Risk Preeclamptic

Suspended·UUniversity of Guadalajara·Phase 2·NCT02838030·82 enrolled

Total Knee Arthroplasty1 trial

Comparative Study of Prophylactic Agent for Venous Thromboembolism After Total Knee Arthroplasty

Completed·HHanyang University Seoul Hospital·Phase 2·NCT02271399·156 enrolled

Rivaroxaban1 trial

Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT02846532·112 enrolled

Anticoagulation1 trial

AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation

Recruiting·OOslo University Hospital·Phase 3·NCT05035277·360 enrolled

Colorectal Polyps1 trial

Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps

Unknown status·QQueen's Medical Center·N/A·NCT00033319

Peripheral Artery Disease1 trial

Residual Platelet Activity In Advanced Peripheral Artery Disease

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01627431·410 enrolled

Screening1 trial

Screening and Multiple Intervention on Lung Epidemics

Active, not recruiting·FFondazione IRCCS Istituto Nazionale dei Tumori, Milano·Phase 2·NCT03654105·2,000 enrolled

Prophylaxis1 trial

Aspirin and Compression Devices for VTE Prophylaxis in Orthopaedic Oncology

Completed·OOhio State University Comprehensive Cancer Center·N/A·NCT01696760·12 enrolled

Relapsing-Remitting Multiple Sclerosis1 trial

Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitting Multiple Sclerosis

Completed· Biogen logo

Biogen·Phase 4·NCT02090413·241 enrolled

Atherosclerosis1 trial

Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid

Completed· Bayer logo

Bayer··NCT03746275·5,798 enrolled

Non-Small Cell Lung Cancer1 trial

Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancer

Terminated·VVanderbilt-Ingram Cancer Center·Phase 1·NCT01707823·4 enrolled

Platelet Function1 trial

Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate

Completed·DDavid Vivas·Phase 1·NCT02243137·30 enrolled

Stent Implantation1 trial

GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation

Completed·EECRI bv·Phase 3·NCT01813435·15,991 enrolled

Esophageal Carcinoma1 trial

Clinical Research on the Effect of Aspirin on the Disease Free Survival Rate of Esophageal Carcinoma

Unknown status·HHebei Medical University Fourth Hospital·Phase 1·NCT03900871·600 enrolled

ESS1 trial

EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye

Terminated·UUniversity Hospital Freiburg·Phase 3·NCT00637468·84 enrolled

Cognitive Functions1 trial

The Impact of Air Travel on Passenger Cognitive Functions

Unknown status·DDinara Zhumanbayeva·Phase 2/3·NCT04802785·50 enrolled

Oral leukoplakia1 trial

Aspirin Mouthwash in Treating Patients With Oral Leukoplakia

Completed·—·Phase 1·NCT01238185·40 enrolled

Platelet Aggregation1 trial

Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients

Unknown status·KKangbuk Samsung Hospital·Phase 4·NCT02933788·116 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Acetylic Salicylic Acid for the Treatment of Chronic Obstructive Pulmonary Disease

Unknown status·MMedical University of Vienna·Phase 2·NCT01328145·74 enrolled

Bipolar Disorder1 trial

Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT)

Completed·LLars Vedel Kessing·Phase 2·NCT05035316·250 enrolled

Ischemia1 trial

Study to Investigate Effects of Antiischemic Drug Therapy in Silent Ischemia

Completed·LLuzerner Kantonsspital·N/A·NCT00382421

Colon Cancer1 trial

A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients

Active, not recruiting·LLeiden University·Phase 3·NCT02301286·770 enrolled

Randomized1 trial

IMPACT: A Randomized WOO Study of Novel Therapeutic Agents in Women Triaged to Primary Surgery for EOC

Completed·HHaukeland University Hospital·Phase 1·NCT03378297·26 enrolled

Intensive Care Unit1 trial

High "on Treatment" Platelet Reactivity in the Intensive Care Unit

Unknown status·MMedical University of Vienna·Phase 2·NCT02285751·200 enrolled

Hemodialysis1 trial

The Effect Of Aspirin On Survival in in Patients Undergoing Chronic Hemodialysis

Completed·SShanghai Jiao Tong University School of Medicine·N/A·NCT02261025·410 enrolled

Antithrombotic1 trial

Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD

Completed·SStefan Engelter·Phase 3·NCT02046460·194 enrolled

Type 2 Diabetes Mellitus1 trial

Acetylsalicylic Acid and Type 2 Diabetes Mellitus

Completed·CCentro Universitario de Ciencias de la Salud, Mexico·Phase 3·NCT03341117·21 enrolled

Tumors1 trial

Anti-platelet + Pembro for H&N Tumors

Completed·MMedical University of South Carolina·Phase 1·NCT03245489·20 enrolled

Aneurysm1 trial

Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms

Unknown status·UUniversitätsmedizin Mannheim·Phase 3·NCT03063541·776 enrolled

Knee Arthroplasty1 trial

VTE Prevention Following Total Hip and Knee Arthroplasty

Recruiting·SSudeep Shivakumar·Phase 3·NCT04075240·5,400 enrolled

CML1 trial

Study to Evaluate the Reinduction and Second Stop of TKI with Ponatinib in CML in Molecular Response (ResToP)

Active, not recruiting·FFundacion CRIS de Investigación para Vencer el Cáncer·Phase 2·NCT04160546·80 enrolled

Intestinal Cancer1 trial

EffectiveNess of Low-dose Aspirin in Prevention of Cancer in the Stomach and Oesophagus (GastrointEstinal Cancer Prevention) - United Kingdom ("ENgAGE - UK"): Study to Evaluate the Risk of Cancer in the Stomach and Oesophagus Among New Users of Low-dose Aspirin Using the THIN Database in the UK

Completed· Bayer logo

Bayer··NCT03743883·99,999 enrolled

Respiratory tract infection1 trial

Placebo and Active Controlled Study to Compare the Antipyretic Efficacy of Aspirin® in Patients With Acute Febrile Upper Respiratory Tract Infections Suspected to be of Viral Origin

Completed· Bayer logo

Bayer·Phase 4·NCT01464944·392 enrolled

Analgesic Efficacy1 trial

Evaluate Analgesic Efficacy of Fast Release Aspirin

Completed· Bayer logo

Bayer·Phase 3·NCT01117636·514 enrolled

Growth1 trial

L-arginine in Treatment of Intrauterine Growth Restriction

Unknown status·—·N/A·NCT03321292·260 enrolled

Low back pain1 trial

Placebo and Active Controlled, Double Dummy Study to Prove Efficacy of Aspirin in Treatment of Acute Low Back Pain

Completed· Bayer logo

Bayer·Phase 3·NCT01028079·338 enrolled

Optical Coherence Tomography1 trial

Optical Coherence Tomography Guided Antithrombotic Treatment After Endovascular Thrombectomy of the Posterior Circulation

Unknown status·SSunnybrook Health Sciences Centre·N/A·NCT04121611·25 enrolled

Observational Study1 trial

Pharmacy Based Pharmacoepidemiological Observational Study With Aspirin Protect 100 mg

Completed· Bayer logo

Bayer··NCT01669824·4,235 enrolled

Statin1 trial

The Effect of Multiple Doses of Epanova® on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01486433·52 enrolled

Transcatheter Aortic Valve Replacement1 trial

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Terminated· Bayer logo

Bayer·Phase 3·NCT02556203·1,653 enrolled

Insulin resistance1 trial

Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease

Completed·UUkrainian Medical Stomatological Academy·Phase 4·NCT03011775·43 enrolled

Single Dose1 trial

Bioequivalence of Single Dose Fast Release Aspirin (1000 mg) Tablet Versus Single Dose of Two 500 mg Fast Release Aspirin Tablets

Completed· Bayer logo

Bayer·Phase 1·NCT03056703·38 enrolled

Tension-type headache1 trial

Placebo and Active Controlled, Double Dummy Study to Compare Efficacy of Aspirin and Ibuprofen in Treatment of Episodic Tension-type Headache

Completed· Bayer logo

Bayer·Phase 4·NCT01464983·1,115 enrolled

ART1 trial

A Study to Learn if There is a Difference in the Blood Levels of Acetylsalicylic Acid When Taken as Different Chewable Tablets on an Empty Stomach by Healthy Participants

Completed· Bayer logo

Bayer·Phase 1·NCT06655194·38 enrolled

Tics1 trial

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AZD3366 in Healthy Subjects, Japanese and Chinese Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT04588727·103 enrolled

Hip Fracture1 trial

HIP Fracture Oral ThromboPROphylaxis (Hip PRO Pilot)

Recruiting·UUniversity of Calgary·Phase 2·NCT05775965·250 enrolled

Efficacy1 trial

Placebo and Active Controlled Study to Assess Efficacy and Tolerability of Aspirin Plus Pseudoephedrine

Completed· Bayer logo

Bayer·Phase 3·NCT01062360·1,016 enrolled

HIV infection1 trial

Inducing Immune Quiescence to Prevent HIV Infection in Women

Completed·UUniversity of Manitoba·N/A·NCT02079077·91 enrolled

Clopidogrel1 trial

Plasma and Platelet microRNAs in Clopidogrel Low Response Patients

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 4·NCT02447809·400 enrolled

Intracytoplasmic Sperm Injection1 trial

Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments

Completed·UUniversity of Oulu·N/A·NCT00683202·374 enrolled

Scleroderma1 trial

Evaluation of Effectiveness of Acetylsalicylic Acid on Markers of Vascular Dysfunction in Scleroderma Patients

Completed·FFederal University of São Paulo·Phase 4·NCT03558854·70 enrolled

Hypertensive1 trial

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects

Completed·BBeata Krasinska·Phase 4·NCT03206944·82 enrolled

Gastrointestinal1 trial

Endoscopic Evaluation of Upper Gastrointestinal (GI) Mucosal Damage Induced by PL-2200 Versus Aspirin in Healthy Volunteers

Completed·PPLx Pharma·Phase 1/2·NCT00872534·204 enrolled

Metastatic Prostate Cancer1 trial

Dexamethasone, Aspirin, and Diethylstilbestrol in Treating Patients With Locally Advanced or Metastatic Prostate Cancer

Completed·SSt. Bartholomew's Hospital·Phase 3·NCT00316927·260 enrolled

Perioperative Bleeding1 trial

Perioperative Bleeding and Aspirin Use in Spine Surgery

Withdrawn·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT02807441

Retinal Artery Occlusion1 trial

A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion

Completed·NNantes University Hospital·Phase 3·NCT03197194·70 enrolled

Trial1 trial

The Nordic Aortic Valve Intervention Trial 4 (NOTION-4)

Active, not recruiting·RRigshospitalet, Denmark·N/A·NCT06449469·352 enrolled

Platelet Inhibition1 trial

Perioperative Platelet Inhibition With Acetylsalicylic Acid in Patients With Resectable Tumors of the Pancreatic Head

Not yet recruiting·GGerman Cancer Research Center·Phase 2·NCT05637567·170 enrolled

CABG1 trial

SAPT Versus DAPT in Incomplete Revascularization After CABG

Recruiting·—·Phase 3·NCT03789916·800 enrolled

Metastatic Head and Neck Cancer1 trial

Flavopiridol in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00020189

Chronic Total Occlusion1 trial

Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)

Withdrawn·BBoston Scientific Corporation··NCT04059536

Pilot Study1 trial

Danish Aspirin Resistance Trial - Pilot Study

Completed·UUniversity of Aarhus·N/A·NCT00389129·60 enrolled

Transient Ischemic Attack1 trial

Dabigatran Following Transient Ischemic Attack and Minor Stroke

Completed·UUniversity of Alberta·Phase 2·NCT02295826·300 enrolled

Thromboembolism1 trial

Risk Stratification Procedure for Thromboembolism Prophylaxis

Completed·MMinistry of Health, Saudi Arabia·Phase 2·NCT04031859·242 enrolled

Schizoaffective Disorder1 trial

Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective Disorder

Unknown status·SSheba Medical Center·Phase 3·NCT01320982·400 enrolled

Adult1 trial

A Trial Investigating Lu AF28996 in Healthy Adult Participants

Completed· Lundbeck logo

Lundbeck·Phase 1·NCT06277609·22 enrolled

Chronic Kidney Disease1 trial

The Effect of Salicylate on Platelet Function in CKD (Chronic Kidney Disease) Patients Treated With Aranesp

Recruiting·ZZealand University Hospital·N/A·NCT04330729·60 enrolled

Kawasaki Disease1 trial

Study of Combined Therapy IVIG-SN 10% and Acetylsalicylic Acid in Kawasaki Disease

Completed·GGreen Cross Corporation·Phase 4·NCT04003844·45 enrolled

Frozen Embryo Transfer1 trial

Treatment Preventive for Pre-eclampsia by Acetylsalicylic Acid in Women Who Underwent Frozen Embryo Transfer

Recruiting·—·Phase 3·NCT05460416·276 enrolled

Pneumonia1 trial

Acetylsalicylic Acid in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients With COVID-19

Unknown status·AAzienda Ospedaliera Universitaria Integrata Verona·Phase 3·NCT04808895·204 enrolled

Symptomatic Venous Thromboembolism (VTE)1 trial

A Phase 3, Multicenter, Double-Blinded, Randomized Study to Evaluate REGN7508, a Factor XI Monoclonal Antibody, Versus Acetylsalicylic Acid for Prophylaxis of Symptomatic Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-ASPEN)

Recruiting· Regeneron logo

Regeneron·Phase 3·NCT07213778·2,000 enrolled

Unspecified3 trials

Naproxen Sodium/ASA Platelet Study

Completed· Bayer logo

Bayer·Phase 1·NCT02229461·117 enrolled

Pharmacodynamic Study of Cilostazol in Healthy Volunteers

Completed· Otsuka logo

Otsuka·Phase 1·NCT02554721·77 enrolled

Mechanism of Dipyridamole Action in Platelets: in Vivo Study With Healthy Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02226926·15 enrolled

Sources

References

[1]
ClinicalTrials.gov — 143 trial records for acetylsalicylic acid. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — acetylsalicylic acid compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for acetylsalicylic acid. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Bayer