Adrenaline

PreclinicalSmall molecule

AARS Pharmaceuticals, Inc.

Adrenaline is one of 122 small molecule programs targeting Inflammatory Response. It is currently in Preclinical.

Indications

Total Trials

Active Trials

121

Competitors

Pipeline

Status by Indication[3][1]

Indication

Inflammatory ResponseActive, not recruiting

Septic ShockActive, not recruiting

ChildrenCompleted

Tranexamic AcidCompleted

Laparoscopic Sleeve GastrectomyNot yet recruiting

Inflammatory ResponsePreclinical

Active, not recruiting

Septic ShockPreclinical

Active, not recruiting

ChildrenPreclinical

Completed

Tranexamic AcidPreclinical

Completed

Laparoscopic Sleeve GastrectomyPreclinical

Not yet recruiting

Competition

Competitive Landscape

72 competitors in Septic Shock

#DrugCompanyPhaseTrials

Proamatine

Takeda

Approved

4 2

Levophed

GGeneral Hospital of Ningxia Medical University

Approved

16 3

Merrem

BB. Braun Medical Inc.

Approved

3 4

Duragesic

CCephalon

Approved

2 5

Florinef

Jazz Pharmaceuticals

Phase 3

5 6

Cyklokapron

JJ Molner

Approved

—7

Osmitrol

BB. Braun Medical Inc.

Approved

—8

Integrilin

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Approved

—9

Methylthioninium Chloride

PProvepharm SAS

Phase 3

10 10

Brevibloc

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalRecruiting

Treatment

NCT07341776

Q2 2027

Phase 3Not yet recruiting

Post Operative Pain

NCT06789575

Clinical

Trials by Indication[1]

Bleeding2 trials

The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

Completed·SSt. Olavs Hospital·Phase 4·NCT01964781·30 enrolled

The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

Completed·RRigshospitalet, Denmark·Phase 3·NCT01708642·106 enrolled

Bronchiolitis2 trials

Nebulized Hypertonic Saline (3%) Versus Nebulized Adrenaline for Treatment of Bronchiolitis

Completed·MMaulana Azad Medical College·N/A·NCT03614273·60 enrolled

Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies.

Terminated·AAssistance Publique - Hôpitaux de Paris·Phase 2/3·NCT02586961·195 enrolled

Treatment2 trials

Steroid Use in Treatment of Allergic Reactions to Food

Recruiting·JJohannes Trueck·Phase 4·NCT07341776·160 enrolled

Adrenaline for the Treatment of No-Reflow in Normotensive Patients

Completed·NNational Institute of Cardiovascular Diseases, Pakistan·Phase 4·NCT04699110·201 enrolled

Tranexamic Acid2 trials

Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy

Completed·—·N/A·NCT06145191·1,013 enrolled

Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding

Completed·—·N/A·NCT04771923·130 enrolled

Safety and Efficacy1 trial

Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy

Recruiting·AARS Pharmaceuticals, Inc.·Phase 4·NCT06834165·600 enrolled

18 more indications

Post Operative Pain1 trial

Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid Surgery

Not yet recruiting·—·Phase 3·NCT06789575·102 enrolled

Total Knee Arthroplasty1 trial

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Completed·—·Phase 4·NCT00562627·102 enrolled

Hemodynamic Stability1 trial

Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization

Completed·HHelse Fonna·Phase 4·NCT02368054·34 enrolled

Acute Bronchiolitis1 trial

Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis

Recruiting·—·Phase 3·NCT06267118·60 enrolled

Cesarean Section1 trial

Manging Post Spinal Hypotension During Elective Cesarean Section

Completed·BBen marzouk Sofiene·Phase 4·NCT03704909·143 enrolled

Cardiac Arrest1 trial

Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest

Completed·SSingapore General Hospital·Phase 3·NCT00358579·727 enrolled

Function1 trial

The Effects of Adrenaline and Milrinone in Patients With Myocardial Dysfunction After CABG

Completed·UUniversity of Luebeck·Phase 3·NCT00446017·60 enrolled

Dexmedetomidine1 trial

Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Nasal Sephoplasty Surgery.

Completed·TTC Erciyes University·Phase 4·NCT01964586·60 enrolled

Cardiogenic Shock1 trial

Study of Multistep Pharmacological and Invasive Management for Cardiogenic Shock

Completed·NNiguarda Hospital·Phase 2·NCT02591771·24 enrolled

CABG1 trial

Comparison Between Levosimendan and Adrenaline in CABG Patients

Unknown status·—·N/A·NCT05222256·52 enrolled

Vasoconstriction1 trial

Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery

Completed·MMarc Tewfik·Phase 4·NCT01706952·45 enrolled

Septic Shock1 trial

Adrenaline V/s Dopamine in Fuid Refractory Septic Shock

Recruiting·LLaiba Qamar·N/A·NCT07273526·90 enrolled

Prevention1 trial

The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow

Recruiting·—·Phase 3·NCT06847568·1,000 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy

Not yet recruiting·IIVO JURISIC·N/A·NCT07084753·36 enrolled

Trial1 trial

Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip

Unknown status·UUniversity of Sao Paulo General Hospital·Phase 4·NCT02537353·40 enrolled

Placenta Previa1 trial

Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS)

Unknown status·—·N/A·NCT06030479·84 enrolled

Inflammatory Response1 trial

Role of Adrenaline in in the Inflammatory Response in Diabetes

Completed·CCees Tack·N/A·NCT05990933·30 enrolled

Children1 trial

Adrenaline Injections to Children Born at Elective CS

Completed·HHvidovre University Hospital·N/A·NCT00322660·270 enrolled

Sources

References

[1]
ClinicalTrials.gov — 27 trial records for Adrenaline. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Adrenaline compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Adrenaline. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — ARS Pharmaceuticals, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: AARS Pharmaceuticals, Inc.

Adrenaline

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q2 2027

Trials by Indication[1]

Bleeding2 trials

Bronchiolitis2 trials

Treatment2 trials

Tranexamic Acid2 trials

Safety and Efficacy1 trial

Post Operative Pain1 trial

Total Knee Arthroplasty1 trial

Hemodynamic Stability1 trial

Acute Bronchiolitis1 trial

Cesarean Section1 trial

Cardiac Arrest1 trial

Function1 trial

Dexmedetomidine1 trial

Cardiogenic Shock1 trial

CABG1 trial

Vasoconstriction1 trial

Septic Shock1 trial

Prevention1 trial

Laparoscopic Sleeve Gastrectomy1 trial

Trial1 trial

Placenta Previa1 trial

Inflammatory Response1 trial

Children1 trial

References

Drug Info

Quick Facts

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