Buffered Lidocaine

PreclinicalSmall molecule

UUniversity of California, San Diego

Buffered Lidocaine is one of 20 small molecule programs targeting Toothache. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

ToothacheActive, not recruiting

Pain ControlRecruiting

InfiltrationCompleted

ToothachePreclinical

Active, not recruiting

Pain ControlPreclinical

Recruiting

InfiltrationPreclinical

Completed

Competition

Competitive Landscape

15 competitors in Pain Control

#DrugCompanyPhaseTrials

Advil

KKenvue Brands

Approved

4 2

Tylenol

KKenvue Brands

Approved

2 3

Neurontin

VViatris Specialty LLC

Approved

1 4

Toradol

JJavelin Pharmaceuticals

Phase 3

10 5

Journavx

Vertex Pharmaceuticals

Phase 3

1 6

Oxycontin

PProtega

Phase 3

6 7

Robaxin

GGrupo Espanol de Tumores Neuroendocrinos

Approved

1 8

MS Contin

HHikma Pharmaceuticals LLC

Phase 3

3 9

Hydrocodone/acetaminophen

AbbVie

Phase 3

1 10

Naproxen Sodium

Bayer

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2028

N/ANot yet recruiting

Pain Control

NCT06974019

N/ARecruiting

Pain Control

NCT06960317

Clinical

Trials by Indication[1]

Lidocaine2 trials

Buffered Lidocaine in the Pediatric Dental Patient

Completed·GGeisinger Clinic·Phase 4·NCT04055116·64 enrolled

Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial

Completed·UUniversity of Washington·Phase 1/2·NCT06661902·350 enrolled

Pain Control2 trials

Empathy Through Pain Control: Buffered Compared to Unbuffered 1% Lidocaine During IUD Placement

Not yet recruiting·UUniversity of California, San Diego·N/A·NCT06974019·68 enrolled

Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements

Recruiting·UUniversity of California, San Diego·N/A·NCT06960317·204 enrolled

Local Anesthesia1 trial

Comparison of Bacteriostatic Saline to Buffered Lidocaine for Ultrasound Guided Hip Joint Injection Local Anesthesia

Completed·MMayo Clinic·Phase 4·NCT02209272·68 enrolled

Toothache1 trial

Effect of Buffered Numbing Solution on Patients With Toothaches

Completed·OOhio State University·N/A·NCT01868776·100 enrolled

Local Anesthetic1 trial

Local Anesthetics for Pain Reduction Prior to IV Line Placement

Completed·—·Phase 4·NCT01759459·150 enrolled

1 more indication

Infiltration1 trial

The Effect of Buffered Lidocaine Versus Nonbuffered Lidocaine on Pain Scores During Infiltration for Vulvar Biopsies

Completed·WWomen and Infants Hospital of Rhode Island·N/A·NCT02698527·128 enrolled

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for Buffered Lidocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Buffered Lidocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Buffered Lidocaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of California, San Diego company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: UUniversity of California, San Diego

Buffered Lidocaine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2028

Trials by Indication[1]

Lidocaine2 trials

Pain Control2 trials

Local Anesthesia1 trial

Toothache1 trial

Local Anesthetic1 trial

Infiltration1 trial

References

Drug Info

Quick Facts

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