hydrocodone/acetaminophen

ApprovedSmall molecule

AbbVie

hydrocodone/acetaminophen is one of 167 small molecule programs targeting Low back pain. It is currently in Approved.

Indications

Total Trials

Active Trials

166

Competitors

Pipeline

Status by Indication[3][1]

Indication

Low Back PainActive, not recruiting

MucositisActive, not recruiting

AbortionActive, not recruiting

Humerus FractureActive, not recruiting

AnxietyActive, not recruiting

OsteoarthritisActive, not recruiting

ToothacheActive, not recruiting

Low Back PainPhase 3

Active, not recruiting

MucositisPhase 3

Active, not recruiting

AbortionApproved

Active, not recruiting

Humerus FractureApproved

Active, not recruiting

AnxietyPreclinical

Active, not recruiting

OsteoarthritisPhase 2

Active, not recruiting

ToothacheApproved

Active, not recruiting

Competition

Competitive Landscape

778 competitors in Osteoarthritis

#DrugCompanyPhaseTrials

hydrocodone/acetaminophen

AbbVie

Approved

1 2

Ilaris

Novartis

Preclinical

2 3

Toradol

Roche

Preclinical

1 4

Platelet Rich Plasma

ZZagazig University

Preclinical

25 5

Cataflam

Bayer Aspirin

Enbrel

2 8

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

1 9

Protonix

WWyeth-Lederle Vaccines

Preclinical

1 10

Catapres

Boehringer Ingelheim

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Pain Control

NCT03823534

Post-ApprovalActive, not recruiting

Non-Opioid Pain Management

NCT06187584

Clinical

Trials by Indication[1]

Acetaminophen4 trials

Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy

Completed· AbbVie logo

AbbVie·Phase 2·NCT01038609·250 enrolled

A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CR®) in Subjects With Acute Pain Following Bunionectomy

Completed·AAbbott·Phase 3·NCT00402792·150 enrolled

A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery

Completed·AAbbott·Phase 2·NCT00404391·210 enrolled

Show 1 more trial

Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed

Completed· Bayer logo

Bayer·Phase 4·NCT04307940·221 enrolled

Low back pain2 trials

Phase 2 Chronic Low Back Pain Study

Completed· AbbVie logo

AbbVie·Phase 2·NCT01364922·168 enrolled

A Study of Pain Relief in Low Back Pain

Completed·AAbbott·Phase 3·NCT00325949·770 enrolled

Acute Pain2 trials

Acute Pain Study Following Bunionectomy

Completed· AbbVie logo

AbbVie·Phase 2·NCT01333722·100 enrolled

A Study Comparing Vicodin® CR and NORCO® to Placebo in Subjects With Acute Pain Following Bunionectomy

Completed·AAbbott·Phase 2·NCT00404222·90 enrolled

Surgery1 trial

The Effect of NSAIDs After a Rotator Cuff Repair Surgery.

Withdrawn·UUniversity of Chicago·Phase 4·NCT02153177

Recurrent1 trial

A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED

Withdrawn·AAntonios Likourezos·Phase 4·NCT03529331

13 more indications

Humerus Fracture1 trial

Post-operative Pain Management in Children With Supracondylar Humerus Fractures

Terminated·—·Phase 4·NCT05640674·29 enrolled

Pain Control1 trial

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Recruiting·SSt. Louis University·Phase 3·NCT03823534·60 enrolled

Anxiety1 trial

Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair

Completed·—·N/A·NCT01053637·85 enrolled

Liposomal Bupivacaine1 trial

Liposomal Bupivacaine in Implant Based Breast Reconstruction

Terminated·LLoma Linda University·N/A·NCT02659501·24 enrolled

Analgesic1 trial

Comparative Efficacy of 4 Oral Analgesics

Completed·MMontefiore Medical Center·Phase 4·NCT02455518·416 enrolled

Abortion1 trial

Hydrocodone For Pain Control in First Trimester Surgical Abortion

Completed·EElizabeth Micks·Phase 4·NCT01330459·121 enrolled

Non-Opioid Pain Management1 trial

SCHF Post-Op Study Between Opioid and Non-Opioid Pain Management

Active, not recruiting·—·Phase 4·NCT06187584·160 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Osteoarthritis1 trial

A Study Comparing the Analgesic Efficacy and Safety of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR)and Placebo in Subjects With Osteoarthritis

Completed·AAbbott·Phase 2·NCT00404183·120 enrolled

Postoperative Analgesia1 trial

Post Operative Analgesia and Patient Satisfaction

Completed·LLoma Linda University·Phase 3·NCT04976387·150 enrolled

Tooth Extraction1 trial

Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction

Completed· AbbVie logo

AbbVie·Phase 2·NCT00935311·122 enrolled

Toothache1 trial

The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache

Completed·—·Phase 4·NCT00574015·18 enrolled

Mucositis1 trial

Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy

Completed·VVanderbilt-Ingram Cancer Center·Phase 3·NCT02480114·79 enrolled

Sources

References

[1]
ClinicalTrials.gov — 23 trial records for hydrocodone/acetaminophen. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — hydrocodone/acetaminophen compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for hydrocodone/acetaminophen. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — AbbVie company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: AbbVie

hydrocodone/acetaminophen

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Acetaminophen4 trials

Low back pain2 trials

Acute Pain2 trials

Surgery1 trial

Recurrent1 trial

Humerus Fracture1 trial

Pain Control1 trial

Anxiety1 trial

Liposomal Bupivacaine1 trial

Analgesic1 trial

Abortion1 trial

Non-Opioid Pain Management1 trial

Perioperative Pain Control1 trial

Osteoarthritis1 trial

Postoperative Analgesia1 trial

Tooth Extraction1 trial

Toothache1 trial

Mucositis1 trial

References

Drug Info

Quick Facts

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