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E-Mycin

(Erythromycin)

ApprovedSmall molecule

AAzurity Pharmaceuticals

Erythromycin is an antibiotic used to treat bacterial infections like pneumonia, strep throat, and skin infections. It can also be used to prevent certain infections and to treat some stomach problems.[2] E-Mycin is currently approved and in use across 34 indications[4].[1]

E-Mycin is one of 632 small molecule programs targeting Gastroparesis. It is currently in Approved.

34

Indications

56

Total Trials

6

Active Trials

631

Competitors

10

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

GastroparesisActive, not recruiting

Bacterial DiseaseActive, not recruiting

ChorioamnionitisActive, not recruiting

Premature Rupture of MembranesActive, not recruiting

BronchiolitisActive, not recruiting

Familial Adenomatous PolyposisActive, not recruiting

Erectile DysfunctionApproved

Eating DisorderApproved

Gram-Positive Bacterial InfectionsActive, not recruiting

Chlamydia Trachomatis Infectious DiseaseApproved

GastroparesisPhase 2

Active, not recruiting

Bacterial DiseaseApproved

Active, not recruiting

ChorioamnionitisPhase 3

Active, not recruiting

Premature Rupture of MembranesPhase 3

Active, not recruiting

BronchiolitisApproved

Active, not recruiting

Familial Adenomatous PolyposisApproved

Active, not recruiting

Erectile DysfunctionApproved

Approved

Eating DisorderApproved

Approved

Gram-Positive Bacterial InfectionsApproved

Active, not recruiting

Chlamydia Trachomatis Infectious DiseaseApproved

Approved

Showing 10 of 34 indications

Competition

Competitive Landscape

949 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

E-Mycin

AAzurity Pharmaceuticals

Eylea

Emend IV

PORTRAZZA

Andriol

Feraheme

AAzurity Pharmaceuticals

Gas-X

PPortuguese Oncology Institute, Coimbra

Vascepa

AAmarin Pharma Inc.

Xylocaine

MMEDRx USA, Inc.

Versed

CConrado Roberto Hoffmann Filho

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Azithromycin

NCT06273891

Post-ApprovalRecruiting

PPROM

NCT06396078

Q4 2050

N/ANot yet recruiting

Trial

NCT06461429

Clinical

Trials by Indication[1]

Azithromycin3 trials

Treatment of ppROM With Erythromycin vs. Azithromycin Trial

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 3·NCT03060473·21 enrolled

Unlocking New Avenues: Azithromycin Vs Erythromycin in Pre-term, Pre-mature Rupture of Membrane Management

Completed·—·Phase 1·NCT07394725·250 enrolled

Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes

Recruiting·IInova Health Care Services·Phase 3·NCT06273891·140 enrolled

Familial adenomatous polyposis2 trials

Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis

Unknown status·Mmichal roll·Phase 4·NCT02175914·20 enrolled

Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version

Unknown status·Mmichal roll·Phase 4·NCT02354560·15 enrolled

Tics2 trials

An Open-Label Study in HIV+ Patients to Determine the Effects of Nevirapine (Viramune) on the Pharmacokinetics of Clarithromycin and Activity of Cytochrome 3A4.

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT00002194·36 enrolled

Study to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil

Completed· UCB logo

UCB·Phase 1·NCT03480243·28 enrolled

Interaction2 trials

TMC435-TiDP16-C115 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC435 and Erythromycin and Between TMC435 and Darunavir/Ritonavir (DRV/r)

Completed· Tibotec Pharmaceuticals, Ireland logo

Tibotec Pharmaceuticals, Ireland·Phase 1·NCT01323257·49 enrolled

A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults

Completed· Takeda logo

Takeda·Phase 1·NCT05995249·172 enrolled

PPROM1 trial

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

Recruiting·OOhio State University·Phase 4·NCT06396078·56 enrolled

44 more indications

Chorioamnionitis1 trial

Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00021671·3,720 enrolled

Premature rupture of membranes1 trial

Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes

Withdrawn·IIndiana University·Phase 3·NCT01556334

Cardiac Repolarization1 trial

Selections of Subjects With Important Changes in Their Cardiac Repolarization Parameters for the Procurement of Skin and Blood Samples

Completed·EEctycell SASU·Phase 1·NCT01338441·130 enrolled

Bronchiolitis1 trial

Use of Erythromycin in Mustard-Induced Bronchiolitis

Completed·—·Phase 4·NCT00367419

Postmenopausal Women1 trial

A Study of the Effects of Erythromycin on the Pharmacokinetics of Relugolix, Estradiol, and Norethindrone in Healthy Postmenopausal Women and on the Pharmacokinetics of Relugolix in Healthy Adult Men

Completed·MMyovant Sciences GmbH·Phase 1·NCT04714554·43 enrolled

Bulimia Nervosa1 trial

Effectiveness of Antibiotic Treatment for Reducing Binge Eating and Improving Digestive Function in Bulimia Nervosa

Completed·NNew York State Psychiatric Institute·Phase 2·NCT00304187·29 enrolled

Antibiotic Therapy1 trial

Effects of Long Term Macrolide Antibiotic Therapy in Patients With COPD

Unknown status·—·Phase 2/3·NCT00147667·120 enrolled

Blepharitis1 trial

Comparative Study in the Efficacy of Topical Besifloxocin With Erythromycin for the Management of Acute Blepharitis

Completed·JJohn, George, M.D.·Phase 4·NCT01478256·30 enrolled

Absorption1 trial

Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers

Completed· Chiesi Farmaceutici S.p.A. logo

Chiesi Farmaceutici S.p.A.·Phase 1·NCT06395610·24 enrolled

Allergic Contact Dermatitis1 trial

Clinical Observations of Pain and Pruritus Induced by Exposure to Allergic Contact Dermatitis Caused by Macrolides

Not yet recruiting·—··NCT06574204·30 enrolled

TIA1 trial

The Effect of Concomitant Administration of Erythromycin and Diltiazem on CYP3A Activity in Healthy Volunteers

Completed·IIndiana University School of Medicine·Phase 4·NCT00318201·7 enrolled

Hermansky-Pudlak syndrome1 trial

Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome

Terminated·NNational Human Genome Research Institute (NHGRI)·Phase 1/2·NCT00467831·3 enrolled

Randomized1 trial

Randomized Control Trial Comparing Prokinetics and Their Influence on Endoscopy Outcomes for Upper GI Bleed.

Terminated·TTexas Tech University Health Sciences Center, El Paso·N/A·NCT02017379·4 enrolled

Upper Gastrointestinal Bleeding1 trial

Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopy in Patients With Upper Gastrointestinal Bleeding

Unknown status·HHospital Universitari de Bellvitge·Phase 3·NCT01716572·122 enrolled

Gastric1 trial

Effect of Metoclopramide Versus Erythromycin on on Gastric Residual Volume

Completed·—·N/A·NCT04682691·50 enrolled

Clinical Trial1 trial

Clinical Trial of Eye Prophylaxis in the Newborn

Completed·NNational Eye Institute (NEI)·Phase 3·NCT00000120

Epidermolysis Bullosa Simplex1 trial

Treatment of Dowling Maera Type of Epidermolysis Bullosa Simplex by Oral Erythromycin

Unknown status·—·Phase 3·NCT01340235·8 enrolled

Chronic Rhinosinusitis1 trial

Efficacy Of Erythromycin Phonophoresis on Chronic Rhinosinusitis

Not yet recruiting·—·N/A·NCT07063082·90 enrolled

Age1 trial

A Study of Verutex (Fusidic Acid), Eritex (Erythromycin) and Fisiogel in the Management of Tarceva-Associated Rash.

Completed· Roche logo

Roche·Phase 3·NCT00718315·201 enrolled

Rivaroxaban1 trial

A Study of Erythromycin and Rivaroxaban in Study Participants With Normal and Reduced Kidney Function

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT01309438·29 enrolled

AIN1 trial

Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT02212821·14 enrolled

Critically Ill Patients1 trial

Methylnaltrexone vs Erythromycin for Facilitating Gastric Emptying Time in Critically Ill Patients

Terminated·SShiraz University of Medical Sciences·Phase 2·NCT01117376·42 enrolled

Bowel Preparation1 trial

Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure

Completed·MMedtronic - MITG·N/A·NCT02481219·122 enrolled

Infants1 trial

Use of Prokinetics in Early Enteral Feeding in Preterm Infants

Withdrawn·—·N/A·NCT01569633

B-cell Malignancy1 trial

Interaction Study of Ibrutinib and Cytochrome P450 (CYP) 3A Inhibitors in Participants With B-cell Malignancy

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02381080·26 enrolled

Pregabalin1 trial

An Investigation of the Effects of Erythromycin on the Pharmacokinetics of the Pregabalin Controlled Release Tablet

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 1·NCT01342198·18 enrolled

Double-blind1 trial

Intravenous Erythromycin Before Endoscopy in Patients With Variceal Bleeding: A Randomized, Double-Blind Trial

Completed·KKing Abdulaziz Medical City·N/A·NCT01060267·102 enrolled

Parkinson's Disease1 trial

Erythromycin in Parkinson's Disease

Completed·VVirginia Commonwealth University·N/A·NCT02005029·18 enrolled

MPA1 trial

Erythromycin in Septic Patients: Immunomodulatory Role and Clinical Impact

Completed·TTunis University·N/A·NCT04665089·110 enrolled

Gastric Emptying1 trial

The Effect of Intravenous Erythromycin on Gastric Emptying in Non-fasted Patients Before Emergency Total Anesthesia

Completed·UUniversity Hospital, Geneva·Phase 2·NCT00827216·132 enrolled

ESS1 trial

Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube

Completed·—·Phase 4·NCT00999232

Cirrhosis1 trial

To Determine the Role of Prokinetics in Feed Intolerance in Critically Ill Cirrhosis

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02528760·83 enrolled

Atorvastatin1 trial

A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT06948747·49 enrolled

Gastroparesis1 trial

Comparison of Two Macrolides, Azithromycin and Erythromycin, for Symptomatic Treatment of Gastroparesis

Terminated·UUniversity of Florida·Phase 2·NCT01323582·26 enrolled

Colorectal Cancer1 trial

Comparison of Two Preemptive Treatment Strategies of Panitumumab Mediated Skin Toxicity and Assessment of QoL in Patient With Ras-wt Colorectal Cancer

Completed·AAIO-Studien-gGmbH·Phase 2·NCT01668498·88 enrolled

Gastrectomy1 trial

Effect of Erythromycin Before Endoscopy of Patients With Subtotal Gastrectomy (STG), High Risk of Gastric Stasis

Completed·TThe Catholic University of Korea·Phase 2·NCT01659619·114 enrolled

Pneumonia1 trial

Effectiveness Study of Integrative Treatment for Pediatric Community Acquired Pneumonia

Unknown status·LLiaoning University of Traditional Chinese Medicine·N/A·NCT02362906·1,500 enrolled

Treatment1 trial

Treatment of Antenatal Chlamydia Infection

Completed·OObafemi Awolowo University Teaching Hospital·Phase 2·NCT01946256·220 enrolled

Apnea1 trial

Study of Erythromycin in GER-Associated Apnea of the Newborn

Unknown status·UUniversity of Virginia·N/A·NCT01825473·40 enrolled

Encephalopathy1 trial

Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

Unknown status·UUPECLIN HC FM Botucatu Unesp·N/A·NCT01097811·20 enrolled

Bronchiectasis1 trial

Long-term Prognosis of Children With Bronchiectasis Treated With Low-dose Erythromycin Intervention

Unknown status·—·N/A·NCT03966066·70 enrolled

Pregnant Women1 trial

Transplacental Transfer of Drugs Used in Pregnant Women

Completed·UUniversity Hospital, Gasthuisberg·N/A·NCT02622802·250 enrolled

Trial1 trial

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol]

Not yet recruiting·UUniversity of Melbourne·N/A·NCT06461429·100,000 enrolled

Unspecified3 trials

The Effect of Motilin on the Frequency and Amount of Food Intake

Enrolling by invitation·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT03024879·15 enrolled

A Study in Healthy People to Test Whether Erythromycin Influences the Amount of BI 1291583 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06917872·20 enrolled

Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility

Completed·MMayo Clinic·Phase 2/3·NCT01379183·40 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

ERYC

NDA NDA050536

Jan 1, 1982

ERYTHROMYCIN

NDA NDA050532

Jan 1, 1982

ILOTYCIN

NDA NDA050368

Jan 1, 1982

STATICIN

NDA NDA050526

Jan 10, 1985

AKNE-MYCIN

NDA NDA050584

Feb 15, 1985

ERYCETTE

NDA NDA050594

Jul 22, 1985

ERYC SPRINKLES

NDA NDA050593

Sep 9, 1986

PCE

NDA NDA050611

Nov 7, 1986

ERYTHROMYCIN

NDA NDA050610

Oct 21, 1987

ERYGEL

NDA NDA050617

Sources

References

[1]
ClinicalTrials.gov — 56 trial records for Erythromycin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — E-Mycin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Erythromycin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Erythromycin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA050617). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Azurity Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Bacterial 70s Ribosome Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AAzurity Pharmaceuticals

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