Diflucan
(Fluconazole)ApprovedSmall molecule
Fluconazole is used to treat fungal infections, including yeast infections and other infections caused by fungi. It works by stopping the growth of fungus in your body.[2] Diflucan is currently approved and in use across 22 indications[4].[1]
Diflucan is one of 316 small molecule programs targeting Fungal Infectious Disease. It is currently in Approved.
22
Indications
173
Total Trials
16
Active Trials
315
Competitors
3
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 22 indications
Competition
Competitive Landscape
123 competitors in HIV Infection
#DrugCompanyPhaseTrials
1Diflucan
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Approved
Retrovir
BBp Consulting, Inc
Approved
Viread
GileadApproved
Zofran
NovartisApproved
Hepsera
GileadApproved
Golytely
BayerApproved
Cabenuva
GSKApproved
Mycobutin
PfizerApproved
Arava
SanofiApproved
Agenerase
GGlaxo Dba Glaxosmithkline
Approved
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Cryptococcal Meningitis19 trials
A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000639·400 enrolled
Show 16 more trials
High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1/2·NCT00885703·168 enrolled
Dexamethasone in Cryptococcal Meningitis
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000776·36 enrolled
Candidiasis15 trials
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Fluconazole Versus Micafungin in Neonates With Candidiasis
Completed·IInstitut National de la Santé Et de la Recherche Médicale, France·Phase 2/3·NCT02145832·100 enrolled
Vulvovaginal Candidiasis15 trials
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Interaction11 trials
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Fungal Infection7 trials
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Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000676·500 enrolled
66 more indications
Infections4 trials
Drug Interactions4 trials
Adult4 trials
Tics4 trials
Show 1 more trial
Prophylaxis4 trials
Fluconazole Prophylaxis of Thrush in AIDS
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00001542·80 enrolled
Show 1 more trial
Liver Transplant4 trials
Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00001107·500 enrolled
Show 1 more trial
Micafungin Versus Fluconazole for Prevention of Invasive Fungal Disease in Living Donor Liver Transplant Recipients
Unknown status·—·Phase 3·NCT01974375·172 enrolled
Crohn's Disease4 trials
Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease
Completed·—·Phase 2·NCT03476317·10 enrolled
Show 1 more trial
Screening3 trials
Invasive Fungal Infection2 trials
Meningitis2 trials
Immunodeficiency2 trials
Fasting Conditions2 trials
ART2 trials
Coccidioidomycosis2 trials
Pityriasis Versicolor2 trials
Treatment1 trial
Fed1 trial
Bioavailability Study of Fluconazole Tablets 200 mg Under Fed Conditions
Completed·—·Phase 1·NCT01511757·15 enrolled
Graft Versus Host Disease1 trial
Patients With Advanced Solid Tumors1 trial
Mortality1 trial
Invasive Fungal Disease1 trial
Bone Marrow Transplant1 trial
Cognitive Disorder1 trial
Mucositis1 trial
Candida Albicans Infection1 trial
Effectiveness1 trial
Drug1 trial
Adult Subject1 trial
Acute Myeloid Leukemia1 trial
Sporotrichosis1 trial
Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00004938·30 enrolled
Bloodstream Infection1 trial
Efficacy1 trial
Open Heart Surgery1 trial
Chorioretinitis1 trial
SD-OCT Guided Treatment of Fungal Chorioretinitis
Unknown status·—··NCT04947592·10 enrolled
Concentration1 trial
Atorvastatin1 trial
Fungal Infectious Disease1 trial
Population Pharmacokinetics of Fluconazole in the Treatment of Neonatal Fungal Infectious Disease
Unknown status·—··NCT05775692·150 enrolled
CAR1 trial
Vietnam Cryptococcal Retention in Care Study Version 1.0
Unknown status·—··NCT02334670·2,612 enrolled
Bone Marrow Transplantation1 trial
MPA1 trial
Mycobacterium Avium Complex1 trial
B-cell Malignancies1 trial
Recurrent1 trial
Lymphoma1 trial
Extracorporeal Membrane Oxygenation1 trial
Antibiotic Prophylaxis1 trial
Histoplasmosis1 trial
Efficacy and Safety1 trial
Advanced Solid Tumors1 trial
Methadone1 trial
Mycoses1 trial
Stem Cell Transplant1 trial
Baricitinib1 trial
Candidemia1 trial
Cystectomy1 trial
Candidiasis, Invasive1 trial
Unspecified10 trials
Show 7 more trials
Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week
Unknown status·—·Phase 4·NCT00537888·200 enrolled
Regulatory
FDA Approval Timeline[5]
Jan 29, 1990
DIFLUCAN
NDA NDA019949
Sep 29, 1992
DIFLUCAN IN DEXTROSE 5% IN PLASTIC CONTAINER
NDA NDA019950
Dec 23, 1993
DIFLUCAN
NDA NDA020090
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Diflucan drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Fluconazole. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details