General anesthetic

ApprovedSmall molecule

IInstitutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu

General anesthetic is one of 160 small molecule programs targeting Neurotoxicity. It is currently in Approved.

Indications

Total Trials

Active Trials

159

Competitors

Pipeline

Status by Indication[3][1]

Indication

NeurotoxicityActive, not recruiting

DeliriumActive, not recruiting

CognitionActive, not recruiting

Total Knee ArthroplastyActive, not recruiting

Cesarean SectionActive, not recruiting

NeurotoxicityPreclinical

Active, not recruiting

DeliriumPreclinical

Active, not recruiting

CognitionPreclinical

Active, not recruiting

Total Knee ArthroplastyApproved

Active, not recruiting

Cesarean SectionPreclinical

Active, not recruiting

Competition

Competitive Landscape

275 competitors in Total Knee Arthroplasty

#DrugCompanyPhaseTrials

General anesthetic

IInstitutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu

Approved

1 2

Cymbalta

Alnylam Pharmaceuticals

Preclinical

5 3

Xarelto

WWim Janssens

Preclinical

5 4

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

4 5

EXPAREL

Pacira Pharmaceuticals, Inc

Preclinical

7 6

Xylocaine

MMEDRx USA, Inc.

Preclinical

2 7

Nucynta

CCollegium Pharmaceutical, Inc.

Preclinical

2 8

Epsom Salt

FFresenius Kabi Oncology Ltd.

Preclinical

1 9

Zanaflex

LLegacy Health System

Preclinical

1 10

Botox

AbbVie

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

N/ANot yet recruiting

Cesarean Section

NCT07334418

Clinical

Trials by Indication[1]

General Anesthesia2 trials

General Anesthesia With or Without Local Ear Block in Middle Ear Surgeries

Completed·AAbd-Elazeem Abd-Elhameed Elbakry·N/A·NCT03569046·80 enrolled

Physiological Effects of Lung Recruitment During General Anesthesia and Low-tidal Volume Ventilation

Completed·—·N/A·NCT03083457·30 enrolled

Erector Spinae Plane Block2 trials

NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block

Completed·IInstitutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu·N/A·NCT06070701·40 enrolled

Erector Spinae Plane Block Versus Paravertebral Block

Completed·UUniversity of Alberta·N/A·NCT03471442·48 enrolled

Neurotoxicity1 trial

Anesthetic Neurotoxicity: the Association Between General Anesthesia and the Level of Plasma Neurofilament Light

Unknown status·CCardiocentro Ticino··NCT04164329·120 enrolled

Magnesium Sulfate1 trial

the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytoma

Completed·NNational Cancer Institute, Egypt·Phase 2·NCT04320589·30 enrolled

MPR1 trial

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

Enrolling by invitation·HHospital for Special Surgery, New York·Phase 3·NCT05444751·142 enrolled

10 more indications

Open Heart Surgery1 trial

Nociception-directed Erector Muscle Spinae Plane Block in Open Heart Surgery

Completed·IInstitutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu·Phase 4·NCT04338984·86 enrolled

Post Operative Pain1 trial

Role of TAP and RS Block in Reduction of Postoperative Pain for Gynecological Surgical Laparoscopic Procedures

Unknown status·—·Phase 2·NCT03536741·70 enrolled

Complication1 trial

Impact of Functional Status on 30-day Resource Utilization and Organ System Complications Following Bariatric Surgery

Completed·UUniversity of Virginia··NCT05917691·65,627 enrolled

Patient Satisfaction1 trial

Patient Satisfaction After Surgery for Otosclerosis Under Local ou General Anesthesia

Completed·RRennes University Hospital··NCT03888079·103 enrolled

Delirium1 trial

Characterisation of Gut Microbiota in Patients Undergoing Gastrointestinal Surgery With Postoperative Delirium (GIM-POD)

Unknown status·—··NCT04316910·30 enrolled

Total Knee Arthroplasty1 trial

Postoperative Pain in Total Knee Arthroplasty: a Comparison Between General and Spinal Anesthesia

Unknown status·MMeir Medical Center·Phase 4·NCT03176758·60 enrolled

Minimal Invasive Cardiac Surgery1 trial

Erector Spinae Plane Block in Minimal Invasive Cardiac Surgery

Unknown status·—·N/A·NCT03825068·20 enrolled

Cognition1 trial

Effects of General Anesthesia on Brain FC and Cognition in Children With Potential Neurological Damage

Unknown status·XXinhua Hospital, Shanghai Jiao Tong University School of Medicine··NCT05602311·120 enrolled

Cesarean Section1 trial

Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study

Not yet recruiting·UUniversity of Pennsylvania·N/A·NCT07334418·600 enrolled

Breast1 trial

MAC vs TIVA Ambulatory Breast Augmentation

Completed·—·Phase 3·NCT03764267·80 enrolled

Sources

References

[1]
ClinicalTrials.gov — 17 trial records for General anesthetic. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — General anesthetic compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for General anesthetic. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: IInstitutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu

General anesthetic

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Trials by Indication[1]

General Anesthesia2 trials

Erector Spinae Plane Block2 trials

Neurotoxicity1 trial

Magnesium Sulfate1 trial

MPR1 trial

Open Heart Surgery1 trial

Post Operative Pain1 trial

Complication1 trial

Patient Satisfaction1 trial

Delirium1 trial

Total Knee Arthroplasty1 trial

Minimal Invasive Cardiac Surgery1 trial

Cognition1 trial

Cesarean Section1 trial

Breast1 trial

References

Drug Info

Quick Facts

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