Oraltag

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Pancreatic CancerColorectal CancerHeart FailureLung CancerCoronary Artery DiseaseKidney DiseaseAcute Kidney InjuryToxicityRenal InsufficiencyPancreatitisMyocardial IschemiaHypothyroidismCritically Ill PatientsCLEMalignant Solid NeoplasmBacterial Infection

335 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

1

Oraltag

GGE Healthcare

Approved

12

Medrol

Pfizer

Preclinical

13

Byetta

AstraZeneca

Preclinical

14

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

15

Xylocaine

MMEDRx USA, Inc.

Preclinical

16

Feraheme

AAzurity Pharmaceuticals

Preclinical

17

Sulfonylureas

Eli Lilly

Preclinical

18

Active Comparator

Moderna

Preclinical

19

Cyclophosphamid

EEssen Biotech

Preclinical

110

HB-Admscs

HHope Biosciences Research Foundation

Preclinical

1Show 33 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Impaired Renal Function2 trials

Comparison of Captisol-Enabled™ Iohexol and Omnipaque™ in Patients With Impaired Renal Function Undergoing Coronary Angiography

Withdrawn·LLigand Pharmaceuticals·Phase 2·NCT04627831

Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

Completed·MMediBeacon·Phase 2·NCT02772276·234 enrolled

Ascites1 trial

Oral Iohexol in the Management of Chylous Ascites After After Retroperitoneal or Extended Lymphadenectomy

Completed·—·Phase 2·NCT06820320·42 enrolled

Pancreatic Cancer1 trial

Prognostic Value of Baseline Computed Tomography (CT) Perfusion Parameters of Pancreatic Cancer for Patients Undergoing Stereotactic Body Radiotherapy or Surgical Resection

Terminated·SStanford University··NCT01326364·6 enrolled

Phase 11 trial

A Phase 1, Open Label, Placebo-Controlled Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects

Completed·GSK·Phase 1·NCT01214993·38 enrolled

Antiretroviral Treatment1 trial

Renal Effect of Stribild or Other Tenofovir DF-containing Regimens Compared to Ritonavir-boosted Atazanavir Plus Abacavir/Lamivudine in Antiretroviral Treatment-naive HIV-1 Infected Adults

Completed·Gilead·Phase 4·NCT02246998·72 enrolled

32 more indications

Biomarkers1 trial

Renal Effects of Hormones/Biomarkers in Transgender PrEP Recipients

Completed·UUniversity of California, San Diego·Phase 4·NCT04742816·42 enrolled

HIV1 trial

Measurement of Glomerular Filtration Rate (GFR) in HIV Patients: Single-center Study Comparing the Accuracy of Estimators of GFR Versus Iohexol Plasma Clearance

Completed·—·Phase 4·NCT02522338·300 enrolled

Intensive Care Unit1 trial

Measuring the Plasma Clearance of Iohexol to Estimate Glomerular Filtration Rate in Intensive Care Unit Patients: Preliminary Feasibility Study

Completed·UUniversity Hospital, Tours·Phase 3·NCT02050269·100 enrolled

Function1 trial

Furosemide and Creatinine Tubular Stress Test in Order to Measure Proximal Tubule Residual Function

Completed·IInstituto Nacional de Cardiologia Ignacio Chavez·Phase 1·NCT05105009·50 enrolled

Toxicity1 trial

Prediction of Excretion and Toxicity of High Dose Methotrexate in Children and Adolescents With ALL

Completed·—·N/A·NCT02133599·23 enrolled

Oral1 trial

Uniformity of Oral Contrast Material in the Bowel

Completed·UUniversity of California, San Francisco··NCT02542046·900 enrolled

Fabry Disease1 trial

A Study of Renal Function in Treatment-naïve, Young Male Patients With Fabry Disease

Terminated·Sanofi·Phase 1·NCT01839526·39 enrolled

Tenofovir1 trial

Tenofovir Pharmacology in Older HIV Infected Individuals

Completed·UUniversity of Colorado, Denver··NCT02304263·45 enrolled

CLE1 trial

Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance

Not yet recruiting·—·Phase 1·NCT05136963·48 enrolled

Contrast Agent1 trial

Virtual Colonoscopy Using Omnipaque as a Contrast Agent

Completed·MMontefiore Medical Center··NCT04582500·50 enrolled

SMA1 trial

Two-Point Measurement of Glomerular Filtration Rate by Iohexol Plasma Disappearance

Completed·UUniversity of Washington··NCT01545531·54 enrolled

Impairment1 trial

A Study of Lanabecestat in Participants With Severe Kidney Impairment Compared to Healthy Participants

Withdrawn·Eli Lilly·Phase 1·NCT03545087

Pancreatitis1 trial

Low-acid Contrast Media for Preventing Post ERCP Pancreatitis

Completed·SShandong University··NCT07391787·3,979 enrolled

Interaction1 trial

A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib on Metformin

Completed·Pfizer·Phase 1·NCT03826602·18 enrolled

Hypothyroidism1 trial

Pediatric Risk of Hypothyroidism With Iodinated Contrast Media

Withdrawn·GGE Healthcare·Phase 4·NCT03631771

ART1 trial

A Study of LY3556050 in Healthy Participants

Completed·Eli Lilly·Phase 1·NCT04156750·34 enrolled

Critically Ill Patients1 trial

Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance

Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT04776486·90 enrolled

Body Weight1 trial

Dosing Iodinated Contrast Media According to Lean vs. Total Body Weight

Completed·NNova Scotia Health Authority·Phase 4·NCT03415997·239 enrolled

ARB1 trial

Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3

Completed·YYale University·Phase 4·NCT04649229·46 enrolled

Vasoconstriction1 trial

Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans

Recruiting·UUniversity of Calgary··NCT05442463·200 enrolled

Abemaciclib1 trial

A Study of the Effect of Abemaciclib on Metformin and Iohexol in Healthy Participants

Completed·Eli Lilly·Phase 1·NCT02884089·40 enrolled

Metformin1 trial

A Study of Effect of LY3556050 on Metformin in Healthy Participants

Completed·Eli Lilly·Phase 1·NCT05615467·18 enrolled

Lung Cancer1 trial

Pulmonary Interstitial Lymphography in Early Stage Lung Cancer

Terminated·SStanford University·N/A·NCT01188486·12 enrolled

Visceral Leishmaniasis1 trial

A First-in-human, Randomized, Subject Blinded, Placebo Controlled, Single and Multiple Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of LXE408 in Healthy Subjects

Completed·Novartis·Phase 1·NCT07809919·88 enrolled

Augmented Renal Clearance1 trial

Fluorescent Probe for Assessment of Renal Elimination

Not yet recruiting·AAaron Cook·Approved·NCT07643467·200 enrolled

Coronary Artery Disease1 trial

Iso-Osmolar vs. Low-Osmolar Contrast Agents for Optical Coherence Tomography

Completed·MMinneapolis Heart Institute Foundation·Approved·NCT05065073·62 enrolled

Glomerular Filtration Rate1 trial

An Open Label, Single-Center, Safety and Pharmacokinetic Study of Lumitrace® Injection (Relmapirazin) and the Use of the MediBeacon® Transdermal GFR System Using the TGFR Reusable Sensor With TGFR Disposable Ring for the Evaluation of Kidney Function in Patients With Heart Failure

Recruiting·MMediBeacon·Preclinical·NCT07349797·15 enrolled

Heart Failure1 trial

Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2

Completed·VVanderbilt University Medical Center·Approved·NCT04113109·46 enrolled

Malignant Solid Neoplasm1 trial

Assessment of Carboplatin Clearance Predictors: A PK Study on NCI-Sponsored Clinical Trials or Standard of Care Treatments Using Carboplatin

Active, not recruiting·NNRG Oncology·Phase 1·NCT03997370·350 enrolled

Bacterial Infection1 trial

Optimization of Beta-lactam Dosing in Critically Ill Patients With Suspected or Documented Antimicrobial Resistant Gram-Negative Infections With Cystatin-C (OPTIMIZE-GNI)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Approved·NCT06709521·161 enrolled

Renal Failure1 trial

Measurement of Iohexol Plasma Clearance in Patients Leaving ICU After Acute Renal Failure

Completed·UUniversity Hospital, Angers·Phase 3·NCT02961478·150 enrolled

Unspecified4 trials

Method VALIDation and Evaluation of Non-radioactive Methods to Measure Glomerular Filtration Rate

Not yet recruiting·UUniversity Medical Center Groningen·N/A·NCT06259422·208 enrolled

Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block

Recruiting·UUniversity Hospitals Cleveland Medical Center·N/A·NCT07174440·32 enrolled

A Phase I, Single-Centre Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of LY3526318, and to Investigate the Effect of LY3526318 on Metformin and Simvastatin Pharmacokinetics in Healthy Male Japanese Participants

Withdrawn·Eli Lilly·Phase 1·NCT05580250

Show 1 more trial

A Phase 1, Randomized, Investigator- and Participant-Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose Study to Characterize the Safety, Tolerability, and Pharmacokinetics of LY4515100 in Healthy Participants and an Open-Label Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics, Safety, and Tolerability of LY4515100 and of LY4515100 on the Pharmacokinetics of CYP and Transporter Substrates in Healthy Participants

Recruiting·Eli Lilly·Phase 1·NCT07339722·123 enrolled

Regulatory

FDA Approval Timeline[4]

Details

Drug Info

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