Lignocaine

PreclinicalSmall molecule

UUniversity of Malaya

Lignocaine is one of 88 small molecule programs targeting Cataract. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

CataractActive, not recruiting

HemorrhoidActive, not recruiting

Laparoscopic Donor NephrectomyUnknown status

Vaginal DeliveryRecruiting

IntraoperativeCompleted

HysteroscopyCompleted

CataractPreclinical

Active, not recruiting

HemorrhoidPreclinical

Active, not recruiting

Laparoscopic Donor NephrectomyPreclinical

Unknown status

Vaginal DeliveryPreclinical

Recruiting

IntraoperativePreclinical

Completed

HysteroscopyPreclinical

Completed

Competition

Competitive Landscape

63 competitors in Cataract

#DrugCompanyPhaseTrials

Eylea

Regeneron

Approved

3 2

Avelox

Bayer

Approved

3 3

Decadron

AAspen Global Incorporated

Approved

13 4

Bromday

BBausch Health Americas, Inc.

Approved

10 5

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

9 6

Lovenox

Sanofi

Approved

1 7

Toradol

Roche

Approved

1 8

Voltaren

Cipro

Deltasone

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Laparoscopic Cholecystectomy3 trials

Intraperitoneal Analgesia After Laparoscopic Cholecystectomy

Completed·—·N/A·NCT00950625·200 enrolled

Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy

Completed·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 4·NCT01717222·50 enrolled

Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy

Recruiting·—·N/A·NCT07192081·116 enrolled

Bronchoscopy2 trials

A Randomized Trial of 4% Nebulized Lignocaine vs. 10% Lignocaine Spray in Patients Undergoing Flexible Bronchoscopy

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT03109392·1,050 enrolled

Comparison of Pre-procedure Lignocaine Spray Versus Spray-as-you-go for Topical Airway Anesthesia in Flexible Bronchoscopy

Completed·SSheikh Zayed Federal Postgraduate Medical Institute·N/A·NCT07084623·50 enrolled

Hysteroscopy1 trial

Comparison Between the Intrauterine Lidocaine and Warm Saline Distention Medium for Pain Relief During Office Hysteroscopy

Completed·—·N/A·NCT06946121·100 enrolled

Lidocaine1 trial

Effect of Addition of Cisatracurium to Lidocaine VS Plain Lidocaine

Completed·WWatim Medical & Dental College·N/A·NCT06214169·44 enrolled

Aesthetic1 trial

Local Anaesthetic for Transvaginal Egg Collection in IVF

Completed·TThe Fertility Centre, New Zealand·N/A·NCT00554424·75 enrolled

16 more indications

Post Operative Pain1 trial

Effect of Intravenous Low-Dose Ketamine Infusion With Intravenous Lignocaine Infusion on Post-Operative Pain in Patients Undergoing Laparoscopic Choleysystectomy Under General Anesthesia

Completed·—·Phase 4·NCT06964555·100 enrolled

Pain1 trial

Pain Reduction After Separators Placement

Unknown status·SSadaf Bashir·Phase 2·NCT05777122·60 enrolled

Hemorrhoid1 trial

"Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")

Recruiting·KKing Edward Medical University·N/A·NCT07159334·64 enrolled

Analgesic Efficacy1 trial

A Study to Assess Analgesic Efficacy of Intravenous Lignocaine

Completed·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 4·NCT01699919·134 enrolled

Laparoscopic Donor Nephrectomy1 trial

Intravenous Lignocaine Infusion in Laparoscopic Donor Nephrectomy

Unknown status·UUniversity of Malaya·N/A·NCT04052867·40 enrolled

Endometriosis1 trial

Pertubation With Lignocaine in Endometriosis

Completed·IIsifer AB·Phase 2·NCT01329796·42 enrolled

Adolescent Idiopathic Scoliosis1 trial

Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery

Completed·UUniversity of Malaya·Phase 4·NCT04931433·115 enrolled

Intraoperative1 trial

Effect of Intravenous Lignocaine Infusion on Intraoperative End Tidal Desflurane Concentration Requirements

Completed·UUniversiti Kebangsaan Malaysia Medical Centre·N/A·NCT06064331·48 enrolled

Prevention1 trial

Effect of Pretreatment of Lignocaine Versus Midazolam in Prevention of Etomidate Induced Myoclonus.

Completed·RRawalpindi Medical College·Phase 4·NCT04921046·224 enrolled

Intraperitoneal1 trial

Analgesic Effect of IntraPeritoneal LIGNOcaine in Gynaecological Open Surgery

Completed·UUniversity of Malaya·N/A·NCT05897385·112 enrolled

Thyroid Surgery1 trial

Efficacy of I/v Nalbuphine v/s Iv Lignocain in Attanuation of Pressor Responseduring Laryngeoscopy and Intubation in Middle Age Patient Planned for Thyroid Surgery

Unknown status·SSheikh Zayed Medical College·Phase 1·NCT05298761·60 enrolled

Children1 trial

Using Lignocaine Spray and Gel to Reduce the Pain Associated With Nasogastric Tube Insertion in Children

Terminated·TThe University of Queensland·N/A·NCT01075789·13 enrolled

Stress Response1 trial

Lignocaine Nebulization for Attenuation of Intubation Stress Response

Unknown status·—·Phase 4·NCT04441073·100 enrolled

Cataract1 trial

Analgetic Effect of Two Solutions of Intracameral Anesthesia During Cataract Surgery in Patients

Completed·MMedical University of Lublin··NCT04166578·62 enrolled

Vaginal Delivery1 trial

Lignocaine vs Bupivacaine Infiltration for Postpartum Perineal Pain After Vaginal Delivery With Episiotomy in Primigravidae

Recruiting·—·N/A·NCT06568289·60 enrolled

Intravenous1 trial

Erector Spinae Plane (ESP) Block vs Intravenous Lignocaine Infusion in (VATS)

Completed·CCentral Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland·N/A·NCT06289790·61 enrolled

Sources

References

[1]
ClinicalTrials.gov — 24 trial records for Lignocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Lignocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Lignocaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Malaya company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: UUniversity of Malaya

Lignocaine

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Laparoscopic Cholecystectomy3 trials

Bronchoscopy2 trials

Hysteroscopy1 trial

Lidocaine1 trial

Aesthetic1 trial

Post Operative Pain1 trial

Pain1 trial

Hemorrhoid1 trial

Analgesic Efficacy1 trial

Laparoscopic Donor Nephrectomy1 trial

Endometriosis1 trial

Adolescent Idiopathic Scoliosis1 trial

Intraoperative1 trial

Prevention1 trial

Intraperitoneal1 trial

Thyroid Surgery1 trial

Children1 trial

Stress Response1 trial

Cataract1 trial

Vaginal Delivery1 trial

Intravenous1 trial

References

Drug Info

Quick Facts

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