Demerol

(Meperidine)

ApprovedSmall molecule

Meperidine is used to treat moderate to severe pain. It's an opioid pain medication that works by changing how your brain and body respond to pain.[2] Demerol is currently approved and in use across 11 indications[4].[1]

Demerol is one of 281 small molecule programs targeting Chronic Pancreatitis. It is currently in Approved.

Indications

Total Trials

Active Trials

280

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Chronic PancreatitisActive, not recruiting

Renal ColicActive, not recruiting

SciaticaApproved

Nausea and VomitingActive, not recruiting

Coronary Artery BypassActive, not recruiting

Sickle Cell DiseaseActive, not recruiting

Cesarean SectionActive, not recruiting

Ischemic StrokeApproved

PapillomaActive, not recruiting

Chronic PancreatitisPreclinical

Active, not recruiting

Renal ColicApproved

Active, not recruiting

SciaticaApproved

Approved

Nausea and VomitingPreclinical

Active, not recruiting

Coronary Artery BypassApproved

Active, not recruiting

Sickle Cell DiseasePhase 1

Active, not recruiting

Cesarean SectionPreclinical

Active, not recruiting

Ischemic StrokeApproved

Approved

PapillomaPhase 1/Phase 2

Active, not recruiting

Competition

Competitive Landscape

430 competitors in Ischemic Stroke

#DrugCompanyPhaseTrials

Demerol

QQuagen

Approved

25 2

Proamatine

Takeda

Preclinical

2 3

Repatha

Amgen

Preclinical

2 4

Levaquin

WWim Janssens

Preclinical

3 5

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Preclinical

1 6

Tylenol

KKenvue Brands

Preclinical

1 7

Xylocaine

CCitius Pharmaceuticals, Inc.

Preclinical

1 8

Statins

Sanofi

Preclinical

1 9

Urokinase

Mmedac GmbH

Preclinical

3 10

Ginkgo Biloba Extract

NNational Center for Complementary and Integrative Health (NCCIH)

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2/3Active, not recruiting

Depression

NCT03167905

Clinical

Trials by Indication[1]

Sedation4 trials

The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy

Completed·UUfuk University·Phase 4·NCT02486328·103 enrolled

Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine.

Completed·PPrince of Songkla University·Phase 4·NCT01709422·140 enrolled

Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years

Completed·UUniversity of Washington·Phase 4·NCT04068948·37 enrolled

Show 1 more trial

Etomidate vs. Midazolam for Sedation During ERCP

Completed·—·Phase 4·NCT02027311·63 enrolled

Remifentanil2 trials

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy

Completed·KKonkuk University Medical Center·Phase 4·NCT01693185·60 enrolled

Comparison Between Two Different Dosages of Remifentanil During Colonoscopy

Completed·OOspedale San Raffaele·Phase 4·NCT01229527·90 enrolled

Spinal Anesthesia2 trials

Prevention of Shivering Associated With Spinal Anesthesia

Unknown status·—·Phase 2/3·NCT06082076·90 enrolled

Comparison of MgSO4 Versus Meperidine for Prevention of Shivering During Spinal Anesthesia

Completed·AAnestesiaR·Phase 4·NCT05110469·100 enrolled

Sickle Cell Disease1 trial

Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease

Completed·MMonica Bhatia·Phase 1·NCT02867800·24 enrolled

Effectiveness1 trial

Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women

Completed·KKanuni Sultan Suleyman Training and Research Hospital·Phase 4·NCT01555671·250 enrolled

15 more indications

Coronary Artery Bypass1 trial

Comparison of Dexmedetomidine and Meperidine for the Prevention of Shivering Following Coronary Artery Bypass Graft

Unknown status·QQianfoshan Hospital·Phase 4·NCT04735965·180 enrolled

Brachytherapy1 trial

Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy

Completed·—·Phase 4·NCT02684942·40 enrolled

Cesarean Section1 trial

Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section

Unknown status·MMakassed General Hospital·N/A·NCT04446715·60 enrolled

Papilloma1 trial

E7 TCR T Cells for Human Papillomavirus-Associated Cancers

Completed·NNational Cancer Institute (NCI)·Phase 1/2·NCT02858310·224 enrolled

Depression1 trial

CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)

Active, not recruiting·KKK Women's and Children's Hospital·Phase 2/3·NCT03167905·881 enrolled

Nausea and vomiting1 trial

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Tolerance1 trial

Meperidine for Patients Expected to Have Poor Tolerance During Diagnostic Esophagogastroduodenoscopy.

Completed·—·N/A·NCT01948921·110 enrolled

Analgesia1 trial

A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus

Completed·MMercy Research·N/A·NCT01741259·273 enrolled

Intravenous1 trial

Analgesic Effects of Intravenous Paracetamol on Labor Pain

Completed·KKing Abdulaziz University·Phase 4·NCT01394731

Gene Therapy1 trial

T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

Terminated·NNational Cancer Institute (NCI)·Phase 1·NCT05035407·36 enrolled

Age1 trial

Meperidine as the Single Sedative Agent During Esophagogastroduodenoscopy

Completed·—·N/A·NCT01547520·140 enrolled

Labor1 trial

Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae

Unknown status·—·Phase 2·NCT01236651·200 enrolled

Renal Colic1 trial

Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic

Completed·IIsmail Tekin·Phase 4·NCT06558916·90 enrolled

Epidural Analgesia1 trial

Epidural Analgesia Versus IV Meperidine for Labor Pain Control

Completed·RRambam Health Care Campus·N/A·NCT00296751·60 enrolled

Cesarean Delivery1 trial

Shivering Treatment After Cesarean Delivery: Meperidine vs. Dexmedetomidine

Completed·—·Phase 3·NCT03115047·80 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

DEMEROL

NDA NDA021171

Jan 1, 1982

DEMEROL

NDA NDA005010

Sources

References

[1]
ClinicalTrials.gov — 25 trial records for Meperidine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Demerol drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Meperidine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Meperidine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA021171). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Quagen company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: QQuagen

Demerol

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Sedation4 trials

Remifentanil2 trials

Spinal Anesthesia2 trials

Sickle Cell Disease1 trial

Effectiveness1 trial

Coronary Artery Bypass1 trial

Brachytherapy1 trial

Cesarean Section1 trial

Papilloma1 trial

Depression1 trial

Nausea and vomiting1 trial

Tolerance1 trial

Analgesia1 trial

Intravenous1 trial

Gene Therapy1 trial

Age1 trial

Labor1 trial

Renal Colic1 trial

Epidural Analgesia1 trial

Cesarean Delivery1 trial

FDA Approval Timeline[5]

References

Drug Info

Quick Facts

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