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Neptazane

(Methazolamide)

ApprovedSmall molecule

WWyeth-Lederle Vaccines

Neptazane is one of 14 small molecule programs targeting Fatigue. It is currently in Approved.

2

Indications

9

Total Trials

1

Active Trials

13

Competitors

1

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

HypoxiaCompleted

HypoxiaApproved

Completed

Competition

Competitive Landscape

20 competitors in Hypoxia

#DrugCompanyPhaseTrials

Actos

Diamox

Inderal

WWyeth-Lederle Vaccines

Zyrtec

Neptazane

WWyeth-Lederle Vaccines

Citicoline

UUniversity of Texas Southwestern Medical Center

Platinol

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Nitrostat

VViatris Specialty LLC

Calcium

Ciprofol

Haisco Pharmaceutical Group Co., Ltd.

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Hypoxia2 trials

AZ, MZ, and the Pulmonary System Response to Hypoxia

Completed·UUniversity of British Columbia·Phase 4·NCT02760121·14 enrolled

Rapid Acclimatization to Hypoxia at Altitude

Completed·—·Phase 1/2·NCT01702025·41 enrolled

Altitude1 trial

Three New Ideas to Protect Special Forces From the Stress of High Altitude

Completed·UUniversity of Colorado, Denver·Phase 4·NCT02463357·148 enrolled

Function1 trial

Stop Retinal Ganglion Cell Dysfunction Study

Terminated·UUniversity of Miami·Phase 3·NCT02390284·28 enrolled

LAM1 trial

Safety Evaluation of Aminophylline and Methazolamide

Completed·PPoudre Valley Health System·Phase 1·NCT01587027·16 enrolled

Cervical Cancer1 trial

Improving Tumor Oxygenation in Cervical Cancer

Withdrawn·UUniversity of California, Irvine·Phase 2·NCT00257829

3 more indications

Intraocular Pressure1 trial

Use of Methazolamide to Lower Intraocular Pressure

Active, not recruiting·UUniversity of Colorado, Denver·Phase 4·NCT05498103·30 enrolled

Fatigue1 trial

Muscle Fatigue and Carbonic Anhydrase Inhibitors

Completed·UUniversity of British Columbia·Phase 4·NCT02758470·13 enrolled

Essential Tremor1 trial

Acamprosate and Methazolamide for Essential Tremor

Withdrawn·HHenry Ford Health System·Phase 2·NCT06312800

Regulatory

FDA Approval Timeline[4]

Nov 25, 1991

NEPTAZANE

NDA NDA011721

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for Methazolamide. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Methazolamide compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Methazolamide. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA011721). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Wyeth-Lederle Vaccines company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: WWyeth-Lederle Vaccines

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