Diamox

(Acetazolamide)

ApprovedSmall molecule

Acetazolamide is used to treat glaucoma (high pressure in the eye), prevent altitude sickness when traveling to high elevations, and help reduce excess fluid in the body in conditions like heart failure or epilepsy.[2] Diamox is currently approved and in use across 56 indications[4].[1]

Diamox is one of 1107 small molecule programs targeting Angle-Closure Glaucoma. It is currently in Approved.

Indications

131

Total Trials

Active Trials

1,106

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Angle-Closure GlaucomaActive, not recruiting

CalcificationActive, not recruiting

Cardiodysrhythmic Potassium-Sensitive Periodic ParalysisApproved

Pseudotumor CerebriApproved

Altitude SicknessActive, not recruiting

Migraine DisorderActive, not recruiting

ToxicityActive, not recruiting

Respiratory FailureActive, not recruiting

Cystoid Macular EdemaActive, not recruiting

StrokeApproved

Angle-Closure GlaucomaApproved

Active, not recruiting

CalcificationPhase 2/Phase 3

Active, not recruiting

Cardiodysrhythmic Potassium-Sensitive Periodic ParalysisApproved

Approved

Pseudotumor CerebriApproved

Approved

Altitude SicknessPhase 3

Active, not recruiting

Migraine DisorderPreclinical

Active, not recruiting

ToxicityPhase 2

Active, not recruiting

Respiratory FailureApproved

Active, not recruiting

Cystoid Macular EdemaPhase 2

Active, not recruiting

StrokeApproved

Approved

Showing 10 of 53 indications

Competition

Competitive Landscape

797 competitors in Hepatocellular Carcinoma

#DrugCompanyPhaseTrials

Diamox

Teva

Approved

131 2

Cysteine Hydrochloride

Novartis

Preclinical

1 3

Ibrance

Pfizer

Preclinical

1 4

Hepsera

Gilead

Preclinical

—5

Apatinib

LLaNova Medicines Zhejiang Co., Ltd.

Preclinical

16 6

Doptelet

AAkarx

Preclinical

1 7

Miraclid

TTechpool Bio-Pharma Co., Ltd.

Preclinical

1 8

Vermox

WWim Janssens

Preclinical

1 9

PD-1 Inhibitor

Johnson & Johnson

Preclinical

2 10

QL1706

Qilu Pharmaceutical Co., Ltd.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Sleep Apnea

NCT02703220

Q4 2026

Phase 1/2Recruiting

OSA

NCT05293600

Phase 2Recruiting

Sleep Apnea

NCT05804084

Post-ApprovalRecruiting

Preoperative

NCT07101250

Phase 2/3Active, not recruiting

Efficacy

NCT06146101

Recruiting

Heart Failure

NCT06285760

Clinical

Trials by Indication[1]

Heart Failure14 trials

Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload

Recruiting·—·Phase 4·NCT06414759·110 enrolled

Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance

Terminated·SStadtspital Zürich·Phase 4·NCT05986773·13 enrolled

Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients

Recruiting·HHelwan University·Phase 3·NCT06535529·60 enrolled

Show 11 more trials

Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

Completed·CCentro Cardiologico Monzino·Phase 4·NCT00517426·20 enrolled

Add-on Diuretics in Acute Decompensated Heart Failure

Recruiting·TTanta University·Phase 2·NCT07372040·66 enrolled

Acetazolamide in Patients With Acute Heart Failure

Unknown status·UUniversity of Sao Paulo General Hospital·Phase 3·NCT03720288·90 enrolled

Predicting Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients

Completed·DDavid Andrew Wellman·N/A·NCT01377987·29 enrolled

Acetazolamide Per os for Decompensation of Heart Failure

Recruiting·—·Phase 4·NCT05802849·400 enrolled

Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload

Recruiting·JJohannes Grand·Phase 4·NCT06166654·939 enrolled

Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)

Completed·ZZiekenhuis Oost-Limburg·Phase 4·NCT03505788·519 enrolled

Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes

Recruiting·UUniversitas Diponegoro·Phase 4·NCT06475105·66 enrolled

Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure

Recruiting·MMansoura University·Phase 2/3·NCT06783166·100 enrolled

Acetazolamide or Metolazone in Acute Heart Failure

Not yet recruiting·CClinica Alemana de Santiago·N/A·NCT06273397·1,050 enrolled

Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY)

Recruiting·PPuerta de Hierro University Hospital··NCT06285760·64 enrolled

Sleep Apnea8 trials

Managing Opioid Related Sleep Apnea With Acetazolamide

Completed·UUniversity of California, San Diego·Phase 2·NCT06043830·39 enrolled

Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT00928655·51 enrolled

Sleep Apnea in Elderly

Recruiting·VVA Office of Research and Development·Phase 4·NCT02703220·100 enrolled

Show 5 more trials

Sleep Apnea: Mechanism and Cerebrovascular Consequences

Withdrawn·UUS Department of Veterans Affairs·N/A·NCT00108602

A Combined Surgical and Medical Approach in Mild Sleep Apnea

Unknown status·UUniversity Hospital, Antwerp·N/A·NCT00497120

Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea

Recruiting·UUniversity of California, San Diego·Phase 2·NCT05804084·60 enrolled

Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea

Recruiting·SShionogi Apnimed Sleep Science·Phase 2·NCT06776432·60 enrolled

Targeting Chemoreceptor Control of Breathing During Sleep to Mitigate Opioid-Associated Sleep Disordered Breathing

Recruiting·VVA Office of Research and Development·Preclinical·NCT05589753·150 enrolled

Altitude8 trials

Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages

Completed·SStanford University·Phase 1·NCT03424226·105 enrolled

Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD

Unknown status·UUniversity of Zurich·Phase 3·NCT04913389·100 enrolled

Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru

Completed·UUniversity of Colorado, Denver·Phase 1/2·NCT01187108·85 enrolled

Show 5 more trials

Pharmacological Countermeasures for High Altitude

Active, not recruiting·—·Phase 4·NCT05300477·18 enrolled

Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude

Completed·MMassachusetts General Hospital·N/A·NCT01519544·34 enrolled

Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03536455·92 enrolled

Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03536520·59 enrolled

Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03536429·99 enrolled

LAM6 trials

Effect of Potassium and Acetazolamide on People With Andersen-Tawil Syndrome

Terminated·UUniversity of Rochester·Phase 1·NCT00839501·3 enrolled

Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT03377049·11 enrolled

Acetazolamide for Treating NPH in Shunt-candidates Patients

Unknown status·RRabin Medical Center·Phase 2·NCT03779594·15 enrolled

Show 3 more trials

Acetazolamide Facilitates Ventilator Weaning

Unknown status·—·N/A·NCT01131377·150 enrolled

Acetazolamide to Prevent Post Operative CSF Leak

Withdrawn·UUniversity of Miami·Phase 2·NCT02902133

Acetazolamide on REM OSA

Completed·—·Phase 1/2·NCT05589792·11 enrolled

Function5 trials

Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude

Unknown status·UUniversity of Zurich·Phase 3·NCT04915365·100 enrolled

Stop Retinal Ganglion Cell Dysfunction Study

Terminated·UUniversity of Miami·Phase 3·NCT02390284·28 enrolled

ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function

Unknown status·NNational University Hospital, Singapore·Phase 4·NCT00485238·60 enrolled

Show 2 more trials

Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude

Unknown status·UUniversity of Zurich·Phase 4·NCT03537924·100 enrolled

Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude.

Unknown status·UUniversity of Zurich·Phase 4·NCT03540914·400 enrolled

64 more indications

Respiratory Disease5 trials

Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03540901·112 enrolled

Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03177811·127 enrolled

Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03177850·185 enrolled

Show 2 more trials

Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease

Completed·UUniversity of Zurich·Phase 4·NCT03156231·185 enrolled

Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03177837·176 enrolled

Intracranial Hypertension4 trials

Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension

Completed·FFayoum University·Phase 1·NCT03963336·48 enrolled

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Terminated·JJaeb Center for Health Research·Phase 3·NCT03501966·7 enrolled

Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide

Recruiting·UUniversity Hospital, Montpellier·N/A·NCT06945848·114 enrolled

Show 1 more trial

Idiopathic Intracranial Hypertension Treatment Trial

Completed·SSt. Luke's-Roosevelt Hospital Center·Phase 2/3·NCT01003639·165 enrolled

Acute Mountain Sickness4 trials

Controlled Hyperventilation as Prophylaxis for Acute Mountain Sickness

Unknown status·HHospital del Trabajador de Santiago·N/A·NCT02972411·30 enrolled

HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men

Completed·UUniversity of Zurich·Phase 4·NCT06499727·303 enrolled

Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Completed·SSheba Medical Center·N/A·NCT01060969·55 enrolled

Show 1 more trial

Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years

Completed·UUniversity of Zurich·Phase 4·NCT03561675·349 enrolled

Obstructive Sleep Apnea3 trials

Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT00714740·49 enrolled

Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea

Completed·UUniversity of California, San Diego·Phase 2·NCT04639193·20 enrolled

Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health

Completed·UUniversity of California, San Diego·Phase 2·NCT05616260·54 enrolled

Treatment3 trials

Buspirone as a Potential Treatment for Recurrent Central Apnea

Terminated·VVA Office of Research and Development·Phase 3·NCT00746954·8 enrolled

Optimal Dosage of Acetazolamide for OSA Treatment

Completed·UUniversity Hospital, Antwerp·Phase 4·NCT04726982·91 enrolled

Treatment of Chronic Mountain Sickness

Completed·CCentre d'Expertise sur l'Altitude EXALT·N/A·NCT04251364·60 enrolled

Sleep Disorder3 trials

A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing

Withdrawn·NNYU Langone Health·N/A·NCT02670096

HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men

Recruiting·UUniversity of Zurich·Phase 4·NCT06498531·270 enrolled

Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03536507·185 enrolled

Altitude Sickness2 trials

Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy

Completed·GGrant S Lipman·Phase 1·NCT03154645·92 enrolled

Altitude Sickness Prevention and Efficacy of Comparative Treatments

Completed·SStanford University·Phase 3·NCT02604173·103 enrolled

Normal Pressure Hydrocephalus2 trials

Normal Pressure Hydrocephalus Treatment by Acetazolamide

Terminated·RRabin Medical Center·Phase 3·NCT02163330·2 enrolled

Acetazolamide Trial in Normal Pressure Hydrocephalus

Active, not recruiting·UUppsala University Hospital·Phase 2·NCT04975269·50 enrolled

Efficacy2 trials

RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA

Active, not recruiting·IIncannex Healthcare Ltd·Phase 2/3·NCT06146101·560 enrolled

Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome

Terminated·MMayo Clinic·Phase 2/3·NCT02904265·3 enrolled

CAR2 trials

Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

Terminated·UUniversity of Pennsylvania·Phase 1·NCT00780325·26 enrolled

Carbonic Anhydrase Inhibitors and Carbonation: A Novel Approach to Reduce Soda Consumption

Enrolling by invitation·UUniversity of Arizona·Phase 1·NCT06110078·44 enrolled

Pulmonary Hypertension2 trials

Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension

Completed·UUniversity of Zurich·Phase 2·NCT01427192·23 enrolled

Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension

Completed·UUniversity of Zurich·Phase 2/3·NCT02755259·33 enrolled

Type 1 Diabetes2 trials

Acetazolamide in Persons With Type 1 Diabetes - Dose Finding

Completed·UUniversity of California, San Diego·Phase 1/2·NCT05473364·12 enrolled

Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial

Recruiting·UUniversity of California, San Diego·Phase 2·NCT06981234·25 enrolled

Headache2 trials

Intracranial Pressure in Experimental Models of Headache

Completed·—·N/A·NCT01288781·23 enrolled

Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Completed·DDanish Headache Center·N/A·NCT01750723·12 enrolled

Intraocular Pressure2 trials

Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis in Intraocular Pressure (IOP) After Bevacizumab

Completed·UUniversity of Sao Paulo·Phase 2·NCT00804921

Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position.

Completed·UUniversity of Nottingham·N/A·NCT03107429·9 enrolled

Prevention2 trials

Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide

Completed·JJi Xunming,MD,PhD·Phase 4·NCT05023941·252 enrolled

Acetazolamide for the Prevention of Post Operative CSF Leak

Withdrawn·UUniversity of Miami·Phase 2·NCT04351061

Ventricular Function2 trials

Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03167034·110 enrolled

Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03173508·110 enrolled

Ataxia1 trial

Acetazolamide Efficacy in Ataxia in PMM2-CDG

Terminated·MMayo Clinic·Phase 2/3·NCT04679389·25 enrolled

ART1 trial

A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning

Withdrawn·UUniversity of Alabama at Birmingham·Phase 1·NCT03806751

Interaction1 trial

Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT01851473·14 enrolled

Ocular Hypertension1 trial

Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab

Completed·UUniversity of Sao Paulo·Phase 2·NCT00864838·56 enrolled

Kidney Stones1 trial

Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones

Withdrawn·—·N/A·NCT00120731

Fall1 trial

Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA

Recruiting·—·Phase 1/2·NCT06091085·36 enrolled

Subarachnoid Hemorrhage1 trial

Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage

Withdrawn·UUniversity of Florida·Phase 2·NCT02165644

Hypoxia1 trial

AZ, MZ, and the Pulmonary System Response to Hypoxia

Completed·UUniversity of British Columbia·Phase 4·NCT02760121·14 enrolled

Glaucoma1 trial

Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection

Completed·MMashhad University of Medical Sciences·N/A·NCT02140450·70 enrolled

Chronic pain1 trial

Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain

Withdrawn·GGeorgetown University·Phase 2·NCT02276989

OSA1 trial

Rescue Pharmacotherapy for OSA

Recruiting·—·Phase 1/2·NCT05293600·70 enrolled

Malignant Glioma1 trial

Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma

Completed·UUniversity of Chicago·Phase 1·NCT03011671·10 enrolled

Women1 trial

HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men

Recruiting·UUniversity of Zurich·Phase 4·NCT06498505·270 enrolled

Cystoid Macular Edema1 trial

Randomized Trial of Acetazolamide for Uveitis-Associated Cystoid Macular Edema

Completed·NNational Eye Institute (NEI)·Phase 2·NCT00000115

Surgery1 trial

Acetazolamide Add-On Therapy to OSA Surgery

Active, not recruiting·UUniversity Hospital, Antwerp·Phase 4·NCT04227093·26 enrolled

Fatigue1 trial

Muscle Fatigue and Carbonic Anhydrase Inhibitors

Completed·UUniversity of British Columbia·Phase 4·NCT02758470·13 enrolled

Hypertension1 trial

A Short Term Open, Randomized Cross-over Trial Exploring the Effect of Carbonic Anhydrase Inhibition by Acetazolamide on Sleep Apnea Associated Hypertension and Vascular Dysfunction

Completed·GGöteborg University·Phase 2·NCT02220803·13 enrolled

Plasma Volume1 trial

HighCycle Study: Acetazolamide, High Altitude and Plasma Volume

Recruiting·CCentre d'Expertise sur l'Altitude EXALT·Phase 4·NCT07118462·270 enrolled

Multiple Sclerosis1 trial

Augmenting Cerebral Blood Flow to Treat Established Multiple Sclerosis

Terminated·TThe University of Texas Health Science Center, Houston·Phase 2·NCT02466074·5 enrolled

Toxicity1 trial

Evaluation of the Effect of Acetazolamide, Mannitol and N-acetylcysteine on Cisplatin-Induced Nephrotoxicity

Completed·—·Phase 2·NCT02760901·52 enrolled

Acute1 trial

Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure

Completed·SSiriraj Hospital·N/A·NCT01923454·15 enrolled

Hyperalgesia1 trial

Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia

Completed·UUniversity of Chile·Phase 4·NCT02992938·50 enrolled

Chronic Obstructive Pulmonary Disease1 trial

Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT01627639·380 enrolled

Retinoschisis1 trial

The AXIS Study: the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in Retinoschisis

Completed·—·Phase 2·NCT06114537·19 enrolled

Bartter syndrome1 trial

Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome

Unknown status·TTehran University of Medical Sciences··NCT03847571·20 enrolled

Calcification1 trial

Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

Terminated·UUniversidad Peruana Cayetano Heredia·Phase 2/3·NCT02945527·4 enrolled

Unknown status·—··NCT02824406·60 enrolled

Mechanical Ventilation1 trial

Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.

Completed·—·Phase 3·NCT01499485·140 enrolled

Wound1 trial

Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

Unknown status·TTehran University of Medical Sciences·Phase 2·NCT01867268·144 enrolled

Orthostatic Intolerance1 trial

Treatment of Orthostatic Intolerance

Active, not recruiting·SSatish R. Raj·Phase 1/2·NCT00262470·150 enrolled

Pulmonary Edema1 trial

Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography

Terminated·VVincent Kan·Phase 4·NCT03490916·18 enrolled

Post Operative Pain1 trial

Impact of Acetazolamide in Reducing Referred Postoperative Pain

Completed·MMedical College of Wisconsin·Phase 1·NCT04470843·33 enrolled

Respiratory Failure1 trial

Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis

Completed·UUniversity of Oslo School of Pharmacy·Phase 4·NCT00222534·70 enrolled

Nephropathy1 trial

Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Completed·SShiraz University of Medical Sciences·Phase 2·NCT00634491·240 enrolled

Chronic1 trial

Chronic Clinical Effect of Acetazolamide

Completed·UUniversity of Zurich·Phase 2/3·NCT02755298·24 enrolled

Aortic Aneurysm1 trial

Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery

Unknown status·LLiverpool Heart and Chest Hospital NHS Foundation Trust·Phase 4·NCT01889498·100 enrolled

Orthostatic Hypotension1 trial

Treatment of Orthostatic Hypotension in Autonomic Failure

Completed·VVanderbilt University·Phase 1·NCT00223691·389 enrolled

Polycythemia1 trial

Treatment of High Altitude Polycythemia by Acetazolamide

Completed·AAssociation pour la Recherche en Physiologie de l'Environnement·Phase 4·NCT00424970·55 enrolled

Metastatic Melanoma1 trial

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT05470283·21 enrolled

Anemia1 trial

Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia

Completed·—··NCT03715972·165 enrolled

Drug1 trial

Bioavailability, Bioequivalence and Tolerability of IHL-42X Compared to the Reference Drugs

Completed·IIncannex Healthcare Ltd·Phase 1·NCT05857384·125 enrolled

Preoperative1 trial

Preoperative Acetazolamide

Recruiting·PPrisma Health-Upstate·Phase 4·NCT07101250·100 enrolled

Cognition1 trial

Effect of Acetazolamide on Cognition in Patients With Respiratory Disease at Altitude

Completed·UUniversity of Zurich·Phase 4·NCT03165890·78 enrolled

Ultrasound1 trial

Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude

Unknown status·UUniversity of Zurich·Phase 4·NCT03539367·100 enrolled

Schizophrenia1 trial

A Randomized Controlled Trial of Acetazolamide for Patients With Treatment Resistant Schizophrenia

Recruiting·VVishwajit Nimgaonkar, MD PhD·Preclinical·NCT04887792·60 enrolled

Central Sleep Apnea1 trial

Impact of Acetazolamide on Central Sleep Apnea Patients Receiving Medication for Opioid Use Disorder

Recruiting·SSanjay R Patel·Phase 2·NCT06521476·40 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

DIAMOX

NDA NDA012945

Jan 1, 1982

DIAMOX

NDA NDA009388

Jan 1, 1982

DIAMOX

NDA NDA008943

Sources

References

[1]
ClinicalTrials.gov — 131 trial records for Acetazolamide. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Diamox drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Acetazolamide compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Acetazolamide. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA012945). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Teva company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Carbonic Anhydrase I Inhibitor; Carbonic Anhydrase II Inhibitor; Carbonic Anhydrase IV Inhibitor; Carbonic Anhydrase XII Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Teva

Diamox

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Heart Failure14 trials

Sleep Apnea8 trials

Altitude8 trials

LAM6 trials

Function5 trials

Respiratory Disease5 trials

Intracranial Hypertension4 trials

Acute Mountain Sickness4 trials

Obstructive Sleep Apnea3 trials

Treatment3 trials

Sleep Disorder3 trials

Altitude Sickness2 trials

Normal Pressure Hydrocephalus2 trials

Efficacy2 trials

CAR2 trials

Pulmonary Hypertension2 trials

Type 1 Diabetes2 trials

Headache2 trials

Intraocular Pressure2 trials

Prevention2 trials

Ventricular Function2 trials

Ataxia1 trial

ART1 trial

Interaction1 trial

Ocular Hypertension1 trial

Kidney Stones1 trial

Fall1 trial

Subarachnoid Hemorrhage1 trial

Hypoxia1 trial

Glaucoma1 trial

Chronic pain1 trial

OSA1 trial

Malignant Glioma1 trial

Women1 trial

Cystoid Macular Edema1 trial

Surgery1 trial

Fatigue1 trial

Hypertension1 trial

Plasma Volume1 trial

Multiple Sclerosis1 trial

Toxicity1 trial

Acute1 trial

Hyperalgesia1 trial

Chronic Obstructive Pulmonary Disease1 trial

Retinoschisis1 trial

Bartter syndrome1 trial

Calcification1 trial

Trial1 trial

Laparoscopic1 trial

Sickle Cell Disease1 trial

Mechanical Ventilation1 trial

Wound1 trial

Orthostatic Intolerance1 trial

Pulmonary Edema1 trial

Post Operative Pain1 trial

Respiratory Failure1 trial

Nephropathy1 trial

Chronic1 trial

Aortic Aneurysm1 trial

Orthostatic Hypotension1 trial

Polycythemia1 trial

Metastatic Melanoma1 trial

Anemia1 trial

Drug1 trial

Preoperative1 trial

Cognition1 trial

Ultrasound1 trial

Schizophrenia1 trial

Central Sleep Apnea1 trial

FDA Approval Timeline[5]

References

Drug Info

Quick Facts