Sulfadoxine pyrimethamine

Phase 3Small molecule

Pfizer

Sulfadoxine pyrimethamine is one of 96 small molecule programs targeting Malnutrition. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

MalnutritionActive, not recruiting

CognitionActive, not recruiting

PregnancyWithdrawn

MalnutritionPreclinical

Active, not recruiting

CognitionPreclinical

Active, not recruiting

PregnancyPhase 3

Withdrawn

Competition

Competitive Landscape

88 competitors in Cognition

#DrugCompanyPhaseTrials

Ketalar

AAultman Health Foundation

Approved

2 2

Duragesic

CCephalon

Approved

1 3

Ambien

PPurdue Pharma LP

Approved

1 4

Osmitrol

BB. Braun Medical Inc.

Namenda

3 6

Epidiolex

Jazz Pharmaceuticals

Phase 2

2 7

Nuplazid

AACADIA Pharmaceuticals Inc.

Phase 2

1 8

Remimazolam Tosilate

FFujian Shengdi Pharmaceutical Co., Ltd.

Phase 3

1 9

Sulfadoxine pyrimethamine

Pfizer

Phase 3

1 10

Psilocybin

COMPASS Pathways

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/AActive, not recruiting

Cognition

NCT05949190

Clinical

Trials by Indication[1]

Malaria28 trials

IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda

Completed·IInstitute of Tropical Medicine, Belgium·Phase 4·NCT00372632·1,717 enrolled

Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi

Completed·CCenters for Disease Control and Prevention·Phase 4·NCT00164710·365 enrolled

A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

Completed·UUniversity of Cape Town·N/A·NCT00203814·280 enrolled

Show 25 more trials

A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

Completed·UUniversity of Cape Town·N/A·NCT00203736·240 enrolled

Chemopreventive Therapy for Malaria in Ugandan Children

Completed·UUniversity of California, San Francisco·Phase 3·NCT00948896·600 enrolled

Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda

Completed·GGrant Dorsey, M.D, Ph.D.·Phase 3·NCT04336189·2,757 enrolled

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2

Completed·RRadboud University Medical Center·N/A·NCT03454048·24 enrolled

Efficacy of Sulfadoxine-Pyrimethamine for Treating Malaria in Gabonese Children

Terminated·—·Phase 4·NCT00453856·139 enrolled

Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan

Unknown status·MMalaria Consortium·Phase 3·NCT05471544·3,575 enrolled

Comparing Chemoprevention Drugs for School-based Malaria Control

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT05980156·646 enrolled

Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa

Terminated· Pfizer logo

Pfizer·Phase 3·NCT01103063·2,891 enrolled

Intermittent Preventive Treatment of Malaria in Schoolchildren

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00852371·780 enrolled

Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda

Unknown status·MMalaria Consortium·Phase 4·NCT05323721·6,805 enrolled

Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria

Completed·CCenters for Disease Control and Prevention·Phase 4·NCT00140361·390 enrolled

Intermittent Preventive Treatment for Malaria in Infants in Navrongo Ghana

Completed·LLondon School of Hygiene and Tropical Medicine·N/A·NCT00857077·2,485 enrolled

Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia

Completed·MMakerere University·Phase 3·NCT00399074·220 enrolled

Controlled Human Malaria Infection Transmission Model - Phase A

Suspended·UUniversity of Oxford·Phase 1/2·NCT04280692·44 enrolled

Combination Antimalarials in Uncomplicated Malaria

Completed·UUniversity of Cape Town·N/A·NCT00203801·700 enrolled

Azithromycin (AZ) and Sulphadoxine-pyrimethamine (SP) for Malaria Prevention in Pregnant Women (IPT-AZ/IPT-SP)

Unknown status·UUnknown Sponsor·N/A·NCT03944317·168 enrolled

Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00289250·360 enrolled

In-Vivo Response of P. Falciparum to Antimalarial Treatment in HIV-Infected and HIV-Uninfected Adults

Completed·CCenters for Disease Control and Prevention·Phase 4·NCT00144352·540 enrolled

Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children

Unknown status·LLondon School of Hygiene and Tropical Medicine·N/A·NCT05354258·600 enrolled

Reducing the Effects of Malaria in Children by Administering Repeated Preventive Doses

Completed·—·Phase 4·NCT00167843·1,189 enrolled

New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa

Completed·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT00730366·2,766 enrolled

Treatment of Uncomplicated Malaria in Benin

Completed·IInstitut de Recherche pour le Developpement·N/A·NCT00460369·240 enrolled

Antimalarial Drug Resistance in Mali

Completed·CCenters for Disease Control and Prevention·N/A·NCT00127998·1,011 enrolled

Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)

Completed·—·Phase 3·NCT04783051·250 enrolled

Impact Evaluation of Intermittent Preventive Treatment of Malaria in Infants Plus (IPTi+) in Côte d'Ivoire: The Plus Project

Completed·LLondon School of Hygiene and Tropical Medicine··NCT05856357·1,381 enrolled

Pregnancy4 trials

Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy

Active, not recruiting·MMenzies School of Health Research·Phase 3·NCT05426434·1,172 enrolled

Chloroquine for Malaria in Pregnancy

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT01443130·900 enrolled

Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy

Terminated·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT00711906·352 enrolled

Show 1 more trial

Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda

Withdrawn·UUniversity of California, San Francisco·Phase 4·NCT01184911

Efficacy and Safety2 trials

Efficacy and Safety of Azithromycin and Artesunate in Pregnant Women

Completed·UUniversity of North Carolina·N/A·NCT00287300·141 enrolled

Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi

Completed·KKamuzu University of Health Sciences·Phase 3·NCT03009526·602 enrolled

Pregnant Women2 trials

Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 2·NCT02909712·201 enrolled

Pharmacokinetics, Efficacy, Gametocyte Carriage, Birth Outcomes Following Sulfadoxine-pyrimethamine Intermittent Presumptive Treatment in Pregnant Women

Completed·PProfessor Karen I Barnes·N/A·NCT00380146·31 enrolled

Treatment2 trials

Intermittent Preventative Treatment With Sulfadoxine-Pyrimethamine in Gambian Multigravidae

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00120809·3,000 enrolled

Intermittent Preventive Treatment in Infant in Mali

Completed·UUniversity of Bamako·N/A·NCT00766662

8 more indications

Prevention2 trials

Prevention of Severe Anaemia in Gambian Children

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00131716·1,200 enrolled

Chemoprevention Efficacy Study in Burkina Faso

Unknown status·MMalaria Consortium·Phase 4·NCT05478954·800 enrolled

Children1 trial

Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren

Completed·UUniversiteit Antwerpen·Phase 3·NCT01722539·616 enrolled

Long-term Follow-up1 trial

Long-Term Follow-up of Children for a 2-Year Period to Confirm the Safety and Immunogenicity of GSK 257049 Vaccine

Completed· GSK logo

GSK·Phase 2·NCT00323622·1,737 enrolled

Azithromycin1 trial

A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women

Unknown status·PPapua New Guinea Institute of Medical Research·Phase 4·NCT02575755·150 enrolled

Malnutrition1 trial

Package of Interventions After Recovering From Moderate Acute Malnutrition

Completed·WWashington University School of Medicine·N/A·NCT02351687·1,499 enrolled

Cognition1 trial

Improving Cognition and Gestational Duration With Targeted Nutrition

Active, not recruiting·WWashington University School of Medicine·N/A·NCT05949190·1,660 enrolled

Anemia1 trial

Impact Evaluation of Intermittent Preventive Treatment of Malaria in Infants Plus (IPTi+) in Cameroon: The Plus Project

Completed·LLondon School of Hygiene and Tropical Medicine··NCT05889052·2,138 enrolled

Unspecified1 trial

Eggs for Gut Health

Completed·WWashington University School of Medicine·N/A·NCT06002438·461 enrolled

Sources

References

[1]
ClinicalTrials.gov — 47 trial records for Sulfadoxine pyrimethamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Sulfadoxine pyrimethamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Sulfadoxine pyrimethamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pfizer

Sulfadoxine pyrimethamine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Malaria28 trials

Pregnancy4 trials

Efficacy and Safety2 trials

Pregnant Women2 trials

Treatment2 trials

Prevention2 trials

Children1 trial

Long-term Follow-up1 trial

Azithromycin1 trial

Malnutrition1 trial

Cognition1 trial

Anemia1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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