Lanoxin
(Digoxin)ApprovedSmall molecule
Digoxin is used to treat heart failure and irregular heartbeats by making the heart beat stronger and more regularly. It helps the heart pump blood more effectively throughout the body.[2] Lanoxin is currently approved and in use across 39 indications[4].[1]
Lanoxin is one of 1028 small molecule programs targeting HIV infection. It is currently in Approved.
39
Indications
174
Total Trials
16
Active Trials
1,027
Competitors
4
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 39 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Lanoxin
AAdvanz Pharma
Approved
Tecentriq
RochePreclinical
Trodelvy
GileadPreclinical
Halaven
EisaiPreclinical
Tykerb
GSKPreclinical
Adriamycin
GGynecologic Oncology Group
Preclinical
Avastin
BBio-Thera Solutions
Preclinical
Nolvadex
SSan Diego Pacific Oncology & Hematology Associates
Preclinical
Prolia
AmgenPreclinical
Gemzar
GGynecologic Oncology Group
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Interaction47 trials
Show 44 more trials
Tics8 trials
Show 5 more trials
Atrial Fibrillation7 trials
Show 4 more trials
Heart Failure6 trials
Show 3 more trials
Single Dose5 trials
Show 2 more trials
64 more indications
Midazolam5 trials
Adult4 trials
Atorvastatin4 trials
Show 1 more trial
A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.
Not yet recruiting·HHangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.·Phase 1·NCT06601517·30 enrolled
ART4 trials
Show 1 more trial
Breast Cancer3 trials
DIG-HIF-1 Pharmacodynamic Trial in Newly Diagnosed Operable Breast Cancer
Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT01763931·6 enrolled
Concentration3 trials
Drug Interactions3 trials
Metformin3 trials
Supraventricular tachycardia2 trials
Prostate Cancer2 trials
Digoxin for Recurrent Prostate Cancer
Completed·SSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·Phase 2·NCT01162135·16 enrolled
Adult Subject2 trials
Drug2 trials
Clinical Trial2 trials
Female2 trials
Phase 12 trials
Gastric Emptying2 trials
Statin2 trials
Drug Metabolism2 trials
Drug Transporter2 trials
Dapagliflozin1 trial
Overweight or Obese1 trial
NASH1 trial
Malignant Tumors1 trial
Type 2 Diabetes Mellitus1 trial
Dilation and Evacuation1 trial
Clinical Pharmacology1 trial
Rheumatoid Arthritis1 trial
Head and Neck Cancer1 trial
Colorectal Cancer1 trial
Amyotrophic Lateral Sclerosis1 trial
Phase II1 trial
TED1 trial
Cirrhosis1 trial
Metastatic Melanoma1 trial
Advanced Solid Tumors1 trial
Advanced Solid Tumor1 trial
Alveolar Soft Part Sarcoma1 trial
Thyroid Carcinoma1 trial
Spironolactone1 trial
Overweight1 trial
AIN1 trial
Semaglutide1 trial
Gastrointestinal1 trial
Caffeine1 trial
Solid Tumors1 trial
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
Active, not recruiting·—·Phase 1·NCT03889795·15 enrolled
Methotrexate1 trial
Congenital Heart Disease1 trial
Obesity1 trial
Unspecified6 trials
Show 3 more trials
Regulatory
FDA Approval Timeline[5]
Jan 1, 1982
LANOXIN
NDA NDA009330
Jul 26, 1982
LANOXICAPS
NDA NDA018118
Sep 30, 1997
LANOXIN
NDA NDA020405
Aug 26, 2004
DIGOXIN
NDA NDA021648
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Lanoxin drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Digoxin. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Sodium/potassium-Transporting Atpase Inhibitor[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- AAdvanz Pharma