Cecon

(ascorbic acid)

ApprovedSmall molecule

Ascorbic acid, also known as vitamin C, is used to prevent and treat vitamin C deficiency (scurvy) and to support immune system function. It's also used as a nutritional supplement to help with wound healing and overall health.[2] Cecon is currently approved and in use across 78 indications[4].[1]

Cecon is one of 1567 small molecule programs targeting Insulin resistance. It is currently in Approved.

Indications

Total Trials

Active Trials

1,566

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Insulin ResistanceActive, not recruiting

ScurvyActive, not recruiting

Urinary Bladder CarcinomaApproved

Endothelial DysfunctionActive, not recruiting

Non-Hodgkins LymphomaApproved

Viral DiseaseApproved

Nicotine DependenceApproved

Neuropathic PainApproved

Muscular DiseaseApproved

Prostate AdenocarcinomaApproved

Insulin ResistancePhase 1/Phase 2

Active, not recruiting

ScurvyApproved

Active, not recruiting

Urinary Bladder CarcinomaApproved

Approved

Endothelial DysfunctionPhase 1

Active, not recruiting

Non-Hodgkins LymphomaApproved

Approved

Viral DiseaseApproved

Approved

Nicotine DependenceApproved

Approved

Neuropathic PainApproved

Approved

Muscular DiseaseApproved

Approved

Prostate AdenocarcinomaApproved

Approved

Showing 10 of 74 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Cecon

MMcGuff Pharmaceuticals, Inc.

Approved

2 2

Adriamycin

GGynecologic Oncology Group

Preclinical

87 3

Spravato

WWim Janssens

Preclinical

2 4

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 5

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 6

Paracetamol

GSK

Preclinical

1 7

Zoladex

Luye Pharma Group Ltd.

Preclinical

8 8

Fentanyl Citrate

IINSYS Therapeutics Inc

Preclinical

2 9

Motexafin Gadolinium

PPharmacyclics LLC.

Preclinical

1 10

Vit D

PPost Graduate Institute of Medical Education and Research, Chandigarh

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1/2Active, not recruiting

Bladder Cancer

NCT04046094

Phase 2Recruiting

Urinary Tract Infection

NCT05913180

Q1 2027

Recruiting

Endothelial Function

NCT06443151

Q3 2027

Phase 1Recruiting

Vascular Dysfunction

NCT04832009

Phase 1/2Recruiting

Insulin Resistance

NCT04715022

Recruiting

Hypertension

NCT06626113

Clinical

Trials by Indication[1]

Ascorbic Acid8 trials

Lead Detoxifying Effects of Ascorbic Acid Among School Going Adolescents of Karachi- A Cluster Randomized Control Trial

Completed·—·Phase 2/3·NCT02745873·144 enrolled

Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicty

Unknown status·—·Phase 4·NCT03921099·40 enrolled

Ascorbic Acid Treatment in CMT1A Trial (AATIC)

Completed·—·Phase 2·NCT00271635·13 enrolled

Show 5 more trials

High Dose Ascorbic Acid Treatment of CMT1A

Completed·WWayne State University·Phase 2/3·NCT00484510·110 enrolled

Study of High Dose Intravenous (IV) Ascorbic Acid in Measurable Solid Tumor Disease

Withdrawn·—·Phase 2·NCT01125449

Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM)

Completed·HHonorHealth Research Institute·Phase 1/2·NCT03410030·27 enrolled

Determining the Safe Dosage of Ascorbic Acid Used in the Treatment of Occluded Totally Implanted Central Venous Catheter

Completed·UUniversity of Sao Paulo·Phase 2·NCT01270152·21 enrolled

Comparison of 4L Polyethylene Glycol and 2L Polyethylene Glycol With Ascorbic Acid in Inactive UC Patients

Completed·KKyungpook National University Hospital·N/A·NCT01929668·114 enrolled

Sepsis4 trials

High Dose Intravenous Ascorbic Acid in Severe Sepsis

Terminated·CChristiana Care Health Services·Phase 2·NCT02734147·24 enrolled

The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis

Completed·LLithuanian University of Health Sciences·N/A·NCT04773717·60 enrolled

Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.

Completed·—·Phase 2·NCT03422159·140 enrolled

Show 1 more trial

Ascorbic Acid (Vitamin C) Infusion in Human Sepsis

Completed·VVirginia Commonwealth University·Phase 1/2·NCT01434121·24 enrolled

COVID-194 trials

High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients

Completed·SSisli Hamidiye Etfal Training and Research Hospital··NCT04710329·78 enrolled

Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP)

Completed·UUniversity of Washington·Phase 2/3·NCT04328961·943 enrolled

Pharmacologic Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment

Unknown status·TThomas Jefferson University·Phase 2·NCT04363216·66 enrolled

Show 1 more trial

Treatment for COVID-19 in High-Risk Adult Outpatients

Terminated·UUniversity of Washington·Phase 2/3·NCT04354428·289 enrolled

Cardiac Surgery4 trials

Vitamin C in Cardiac Surgery Patients

Completed·GGeisinger Clinic·Phase 1·NCT03123107·6 enrolled

Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac Surgery

Completed·MMayo Clinic·Phase 1·NCT03744702·15 enrolled

Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients

Completed·RRutgers, The State University of New Jersey·Phase 4·NCT01167569·57 enrolled

Show 1 more trial

High Dose Vitamin C in Cardiac Surgery Patients

Terminated·VVirginia Commonwealth University·Phase 1·NCT02762331·6 enrolled

Pancreatic Cancer3 trials

High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

Withdrawn·PPiedmont Cancer Institute·Phase 1/2·NCT03797443

High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

Withdrawn·HHitendra Patel·Phase 1/2·NCT03697239

High Dose Ascorbic Acid and Nanoparticle Paclitaxel Protein Bound and Cisplatin and Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

Withdrawn·MMedical College of Wisconsin·Phase 1/2·NCT03908333

64 more indications

Multiple Myeloma2 trials

Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Treating Patients With Multiple Myeloma

Withdrawn·TThe Cleveland Clinic·Phase 2·NCT00112879

Melphalan, Arsenic Trioxide, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma

Withdrawn·OOncotherapeutics·Phase 2·NCT00085345

Effectiveness2 trials

The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients

Unknown status·NNational Taiwan University Hospital·Phase 1/2·NCT04035096·40 enrolled

Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly.

Completed·YYolanda de Diego Otero·Phase 2·NCT02793648·50 enrolled

Septic Shock2 trials

Vitamin C Deficiency in Septic Shock

Completed·—·Phase 4·NCT06224881·150 enrolled

Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.

Completed·UUniversity of Wisconsin, Madison··NCT03913468·206 enrolled

Post Operative Pain2 trials

Vitamin C Efficacy in Reducing Post Operative Pain

Completed·—·Phase 4·NCT01322061·80 enrolled

Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Unknown status·—·N/A·NCT05478044·30 enrolled

Liver Transplant2 trials

Ascorbic Acid to Prevent Postreperfusion Syndrome in Liver Transplantation

Unknown status·HHospital Universitario Ramon y Cajal·Phase 2·NCT05754242·70 enrolled

Parenteral Ascorbic Acid Repletion in TransplantatIon (PARTI): A Randomized, Double-Blinded, Placebo-Controlled Trial

Suspended·UUniversity of Wisconsin, Madison·Approved·NCT04756063·90 enrolled

Complication2 trials

Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery

Not yet recruiting·QQianfoshan Hospital·Phase 2·NCT06421688·86 enrolled

Effect of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery

Unknown status·XXuzhou Medical University·Phase 1·NCT03756727·110 enrolled

Vascular Dysfunction2 trials

Targeting ER Stress in Vascular Dysfunction

Terminated·—·Phase 1·NCT04001647·17 enrolled

Reversing Glucose and Lipid-mediated Vascular Dysfunction

Recruiting·UUniversity of Kansas Medical Center·Phase 1·NCT04832009·46 enrolled

Acute Lung Injury2 trials

Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury

Completed·VVirginia Commonwealth University·Phase 2·NCT02106975·170 enrolled

Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury

Completed·—·Phase 2·NCT04153487·40 enrolled

Breast Cancer2 trials

Intravenous Ascorbic Acid Supplementation in Neoadjuvant Chemotherapy for Breast Cancer

Unknown status·—·Phase 1/2·NCT03175341·30 enrolled

Intravenous Ascorbic Acid in Women Receiving Adjuvant or Neo-Adjuvant Chemotherapy for Early Stage Breast Cancer

Withdrawn·MMidwestern Regional Medical Center·Phase 2·NCT02521077

Atrial Fibrillation2 trials

Vitamin C and Atrial Fibrillation After Cardiac Surgery

Withdrawn·—·Phase 3·NCT01580683

Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery

Completed·MMaineHealth·Phase 3·NCT00953212·304 enrolled

Prevention2 trials

Vitamin C for the Prevention of UTI in Women Who Undergo Elective Gynecological Surgeries

Withdrawn·—·Phase 1·NCT04261036

Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries

Withdrawn·—·Phase 1·NCT03800667

Intraoperative1 trial

Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma

Completed·SSeoul National University Hospital·Phase 3·NCT01715597·50 enrolled

Influenza1 trial

A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies

Completed· GSK logo

GSK·Phase 4·NCT01332578·25 enrolled

Injury1 trial

VItamin C in Thermal injuRY: The VICToRY Trial

Suspended·—·Phase 3·NCT04138394·666 enrolled

Glucocorticoids1 trial

Ascorbic Acid Treatment in Congenital Glucocorticoids and Mineralocorticoids Deficiency Due to NNT Mutation

Unknown status·HHadassah Medical Organization·N/A·NCT02838472·3 enrolled

Liver1 trial

Delivery of Inhibitors of Lysyl Oxidase (LysoLox) on Serial Angioplasty and Time to Restenosis

Unknown status·SSoutheast Renal Research Institute·Phase 2·NCT03106948·30 enrolled

Kidney Cancer1 trial

Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery

Terminated·—·Phase 2·NCT03334409·5 enrolled

Critically Ill Patients1 trial

Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients

Completed·AAmsterdam UMC, location VUmc·Phase 4·NCT02455180·20 enrolled

Hypertension1 trial

Transduction of Sympathetic Neural Activity in Human Obesity Without Hypertension

Recruiting·UUniversity of Kansas Medical Center··NCT06626113·60 enrolled

Renal insufficiency1 trial

NASPI: N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization

Completed·SSeoul National University Hospital·Phase 4·NCT00356954·250 enrolled

Function1 trial

Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair

Not yet recruiting·MMahidol University·Phase 4·NCT06384833·110 enrolled

Arsenic Trioxide1 trial

Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00661544·48 enrolled

Patients With Solid Tumors1 trial

Study of High-Dose Intravenous (IV) Vitamin C Treatment in Patients With Solid Tumors

Completed·MMidwestern Regional Medical Center·Phase 1·NCT00441207·18 enrolled

Efficacy and Safety1 trial

Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca

Terminated·TThomas Jefferson University·Phase 2·NCT01555489·11 enrolled

Radiation Therapy1 trial

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

Active, not recruiting·—·Phase 2·NCT02905591·43 enrolled

Glioblastoma Multiforme1 trial

A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme

Active, not recruiting·BBryan Allen·Phase 2·NCT02344355·90 enrolled

Colorectal Cancer1 trial

Vitamin C Intravenously With Chemotherapy in Advanced Colorectal Cancer

Completed·SSun Yat-sen University·Phase 3·NCT02969681·442 enrolled

MPA1 trial

Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation

Withdrawn·UUniversity of Wisconsin, Madison·Phase 1·NCT03066115

Gastric Cancer1 trial

IV Ascorbic Acid in Advanced Gastric Cancer

Unknown status·SSun Yat-sen University·Phase 3·NCT03015675·200 enrolled

Acute Promyelocytic Leukemia1 trial

Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-Acute Promyelocytic Leukemia (APL) Acute Myelogenous Leukemia

Terminated·UUniversity of Southern California·Phase 2·NCT00184054·11 enrolled

Estrogen1 trial

Women's Angiographic Vitamin and Estrogen Trial (WAVE)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000555

Anemia1 trial

Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients

Unknown status·AAnemia Working Group Romania·Phase 4·NCT02225886·100 enrolled

Gingival Recession1 trial

How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?

Not yet recruiting·MMinia University·N/A·NCT06936592·30 enrolled

Oral Mucositis1 trial

Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers

Completed·PPanineeya Mahavidyalaya Institute of Dental Sciences & Research Centre·Phase 2/3·NCT02868151·180 enrolled

Blood Pressure1 trial

Effect of Low Doses of Vitamin C on Salivary Cortisol , Heart Rate , Blood Pressure During Group Presentation

Completed·—·Phase 4·NCT04135378·90 enrolled

Metastatic Colorectal Cancer1 trial

Combination of IV Ascorbic Acid and Adebrelimab in Metastatic Colorectal Cancer

Recruiting·FFudan University·Phase 3·NCT04516681·400 enrolled

Lung Cancer1 trial

Pharmacological Ascorbate for Lung Cancer

Completed·—·Phase 2·NCT02420314·55 enrolled

Drug1 trial

A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00037063

Temporomandibular Joint Disorder1 trial

Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD).

Completed·SSpherium Biomed·Phase 1/2·NCT02602483·96 enrolled

Cancer1 trial

Vitamin C as an Anti-cancer Drug

Completed·—·Phase 2·NCT01080352·31 enrolled

Tachycardia1 trial

Local Vasoconstriction in Postural Tachycardia Syndrome

Completed·NNew York Medical College·Phase 1·NCT01210430·74 enrolled

Oxidative Stress1 trial

Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes

Completed·—·N/A·NCT00845130·42 enrolled

Urinary Tract Infection1 trial

Vitamin C Effectiveness in Preventing Urinary Tract Infections After Gynecological Surgeries

Recruiting·—·Phase 2·NCT05913180·180 enrolled

Type 2 Diabetes1 trial

Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes

Completed·UUniversity of Colorado, Denver·N/A·NCT00786019·47 enrolled

Hyperpigmentation1 trial

Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation

Completed·—·Phase 4·NCT03252418·10 enrolled

Treatment1 trial

Topical Vitamin C for Treatment of Basal Cell Cancer

Completed·CCenter for Biomedical Research, Inc.·Phase 1·NCT04279535·25 enrolled

Ischemic stroke1 trial

Prevention and Treatment for Bruises in Patients with Ischemic Stroke

Not yet recruiting·—·Phase 4·NCT06823999·400 enrolled

Insulin resistance1 trial

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

Recruiting·UUniversity of Kansas Medical Center·Phase 1/2·NCT04715022·23 enrolled

Fatigue1 trial

High-dose Ascorbic Acid Intravenous Injection Decreases Mitochondrial DNA Damage in Chronic Fatigue Patients: Randomized-controlled Study

Unknown status·YYonsei University·Phase 4·NCT01926132·60 enrolled

Encephalopathy1 trial

Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy

Completed·—·N/A·NCT00624871·60 enrolled

Psychosis1 trial

Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk

Completed·KKing's College London·N/A·NCT06190483·24 enrolled

Vascular Access1 trial

Ascorbic Acid on Restenosis of Dysfunctional Hemodialysis Vascular Access

Completed·NNational Taiwan University Hospital Hsin-Chu Branch·Phase 2·NCT03524846·93 enrolled

Non-Small Cell Lung Cancer1 trial

Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer

Recruiting·TThe Canadian College of Naturopathic Medicine·Phase 2·NCT05849129·90 enrolled

Critically Ill1 trial

High Dose Vitamin C in the Critically Ill Patient

Terminated·RRutgers, The State University of New Jersey·Phase 2·NCT01587963·11 enrolled

Bladder Cancer1 trial

Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients

Active, not recruiting·UUniversity of Kansas Medical Center·Phase 1/2·NCT04046094·12 enrolled

Thoracic Surgery1 trial

Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation

Completed·HHartford Hospital·Phase 4·NCT00519337·25 enrolled

Endothelial Dysfunction1 trial

Clinical Utility of Endothelial Dysfunction in PAD

Terminated·—·Phase 1·NCT00491751·108 enrolled

Myelodysplastic Syndromes1 trial

TET2 Mutations in Myelodysplastic Syndromes and Acute Myeloid Leukemia With Azacitidine + Ascorbic Acid

Completed·—·Phase 2·NCT03397173·12 enrolled

Trial1 trial

Phosphate Lowering in CKD Trial

Completed·VVA Office of Research and Development·Phase 4·NCT02209636·66 enrolled

Endothelial Function1 trial

Role of Endothelial Function in SCI CVD Risk

Recruiting·—··NCT06443151·60 enrolled

Lung Transplant1 trial

Use of ARINA-1 in an Intermediate Size Patient Population of Bilateral Lung Transplant Patients With CLAD Grade 0

Completed·—·Phase 1·NCT03226431·6 enrolled

AIN1 trial

"Novo C Plus" Vitamin C Containing Dietary Supplement Bioavailability in Healthy Subjects

Completed·SSemmelweis University·Phase 1·NCT02606773·32 enrolled

Colorectal1 trial

Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA

Terminated·TThomas Jefferson University·Phase 1/2·NCT01550510·4 enrolled

End-Stage Renal Disease1 trial

The Effect of Vitamin C and E Therapy on Restless Leg Syndrome in Patients With End Stage Renal Disease on Haemodialysis

Unknown status·KKing Abdulaziz University·Phase 3·NCT05350124·160 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 2, 2017

ASCOR

NDA NDA209112

Sources

References

[1]
ClinicalTrials.gov — 98 trial records for ascorbic acid. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Cecon drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — ascorbic acid compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for ascorbic acid. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA209112). U.S. Food & Drug Administration.
[6]
SEC EDGAR — McGuff Pharmaceuticals, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: MMcGuff Pharmaceuticals, Inc.