Ketofol

ApprovedSmall molecule

TTanta University

Ketofol is one of 65 small molecule programs targeting Sedation. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

DeliriumActive, not recruiting

Inguinal HerniaActive, not recruiting

Critically IllRecruiting

DeliriumApproved

Active, not recruiting

Inguinal HerniaPreclinical

Active, not recruiting

Critically IllPhase 3

Recruiting

Competition

Competitive Landscape

167 competitors in Delirium

#DrugCompanyPhaseTrials

Victoza

Novo Nordisk

Phase 3

1 2

Ritalin

Novartis

Phase 3

1 3

Ketofol

TTanta University

Approved

1 4

Physostigmine

AstraZeneca

Phase 3

1 5

Rozerem

Takeda

Preclinical

6 6

Inapsine

Alnylam Pharmaceuticals

Preclinical

1 7

Anerem

AAcacia Pharma Ltd

Preclinical

7 8

Spravato

WWim Janssens

Preclinical

4 9

Raldesy

PPragma

Preclinical

3 10

Bridion

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Critically Ill

NCT07530146

Clinical

Trials by Indication[1]

Sedation3 trials

Ketofol Versus Fentofol for Procedural Sedation in the Pediatric Emergency Department

Completed·UUniversity of British Columbia·Phase 3·NCT02079090·30 enrolled

Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 4·NCT02867930·50 enrolled

Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia

Completed·LLions Gate Hospital·Phase 3·NCT01211158·284 enrolled

Upper Gastrointestinal Endoscopy1 trial

Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy

Terminated·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT02643979·22 enrolled

Inguinal hernia1 trial

Dexmedetomidine vs Ketofol on Delirium in Children Undergoing Congenital Inguinal Hernia Repair

Unknown status·TTanta University·N/A·NCT05786833·60 enrolled

Premedication1 trial

Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.

Unknown status·—·Phase 4·NCT06010927·140 enrolled

Propofol1 trial

Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive Therapy

Completed·—·N/A·NCT07273851·80 enrolled

5 more indications

Open Heart Surgery1 trial

Neuroprotection During Open Heart Surgery

Completed·Gghada fouad·Phase 3·NCT04486690·50 enrolled

Delirium1 trial

Ketofol for Preventing Postoperative Delirium in Elderly Patients

Completed·ZZagazig University·Phase 4·NCT04816162·120 enrolled

Gastrointestinal Endoscopy1 trial

Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy

Not yet recruiting·GGiresun University··NCT07401914·90 enrolled

Anesthesia1 trial

Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECT

Recruiting·MMedical University of Vienna·Phase 4·NCT05655754·100 enrolled

Critically Ill1 trial

Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation

Recruiting·HHelwan University·Phase 3·NCT07530146·41 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for Ketofol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ketofol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ketofol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Tanta University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: TTanta University

Ketofol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Sedation3 trials

Upper Gastrointestinal Endoscopy1 trial

Inguinal hernia1 trial

Premedication1 trial

Propofol1 trial

Open Heart Surgery1 trial

Delirium1 trial

Gastrointestinal Endoscopy1 trial

Anesthesia1 trial

Critically Ill1 trial

References

Drug Info

Quick Facts

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