L-carnitine

Phase 3Small molecule

IIperboreal Pharma Srl

L-carnitine is one of 94 small molecule programs targeting Diabetic Foot Ulcer. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Diabetic Foot UlcerRecruiting

Reperfusion Injury, MyocardialActive, not recruiting

Pre-TermRecruiting

DrivingCompleted

CARActive, not recruiting

WomenCompleted

Childhood Apraxia of SpeechNot yet recruiting

ToxicityRecruiting

PhenylketonuriaActive, not recruiting

Diabetic Foot UlcerPhase 2

Recruiting

Reperfusion Injury, MyocardialPhase 2

Active, not recruiting

Pre-TermPreclinical

Recruiting

DrivingPreclinical

Completed

CARPhase 3

Active, not recruiting

WomenPreclinical

Completed

Childhood Apraxia of SpeechPhase 2

Not yet recruiting

ToxicityPhase 2

Recruiting

PhenylketonuriaPhase 3

Active, not recruiting

Competition

Competitive Landscape

62 competitors in Toxicity

#DrugCompanyPhaseTrials

Norvir

AbbVie

Approved

1 2

Zyvox

Pfizer

Approved

1 3

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

3 4

Xeloda

EEngelhard Arzneimittel GmbH & Co.KG

Approved

2 5

Atropen

FFresenius Kabi Taiwan Ltd.

Approved

1 6

Rayos

RRoxane Laboratories

Approved

1 7

Cubicin

BBaxter Healthcare Corporation

Approved

1 8

Prezista

WWim Janssens

Approved

1 9

Vancocin

HHikma Pharmaceuticals LLC

Approved

1 10

Ativan

BBausch Health Americas, Inc.

Approved

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Toxicity

NCT07108777

Phase 2Active, not recruiting

Reperfusion Injury, Myocardial

NCT06564909

Q1 2027

ApprovedRecruiting

Hepatic

NCT07642076

Q3 2027

Phase 2Recruiting

Diabetic Foot Ulcer

NCT07768228

Q4 2027

Phase 2Not yet recruiting

Childhood Apraxia of Speech

NCT07216001

Clinical

Trials by Indication[1]

Fatigue3 trials

L-carnitine to Treat Fatigue Associated With Crohn's Disease

Withdrawn·UUniversity of California, San Francisco·N/A·NCT01523106

L-Carnitine to Treat Fatigue in AIDS Patients

Completed·NNational Institute of Nursing Research (NINR)·Phase 2·NCT00079599·44 enrolled

Developmental Study on Fatigue in Cancer

Completed·NNational Center for Complementary and Integrative Health (NCCIH)·Phase 2·NCT00034450·140 enrolled

Peritoneal Dialysis2 trials

L-Carnitine as an Osmo-metabolic Agent for Peritoneal Dialysis

Completed·IIperboreal Pharma Srl·Phase 2·NCT00851838·5 enrolled

L-Carnitine in Peritoneal Dialysis

Completed·IIperboreal Pharma Srl·Phase 2·NCT00922701·4 enrolled

Anemia2 trials

Effect of Oral L-carnitine Supplement on Lipid Profile, Anemia, and Quality of Life of Patients

Completed·IIsfahan University of Medical Sciences·Phase 2·NCT01278693·54 enrolled

Hydoxycarbamide and L-Carnitine Therapy in Sickle Cell Anemia

Completed·—·Phase 4·NCT05081349·91 enrolled

Dialysis Patients2 trials

Carnitine Supplementation in Pediatric Hemodialysis Patients

Unknown status·—·Phase 1·NCT05948124·40 enrolled

Early Administration of L-carnitine in Hemodialysis Patients

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00322322·110 enrolled

Hemodialysis2 trials

Oral L-carnitine and Inflammatory and Nutritional Biomarkers in Maintenance Hemodialysis

Completed·DDarya Chamani·Phase 2·NCT07249229·50 enrolled

Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis

Unknown status·NNational Taiwan University Hospital·Phase 4·NCT00173706·40 enrolled

41 more indications

Toxicity1 trial

L-Carnitine Protective Effect in Nephrotoxicity

Recruiting·TTanta University·Phase 2·NCT07108777·46 enrolled

Varicocelectomy1 trial

Medical Treatment Alone Versus Varicocelectomy Versus Varicocelectomy and Medical Treatment

Recruiting·SSouth Valley University·N/A·NCT07016867·126 enrolled

Body Weight1 trial

Effect of the Administration of L-Carnitine on Body Weight in Women in Crossfit Training

Unknown status·UUniversity of Guadalajara·Phase 2·NCT03436277·24 enrolled

Pyelonephritis1 trial

L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis

Unknown status·SShahid Beheshti University·Phase 3·NCT02007889·78 enrolled

Pre-Term1 trial

Effect of L-Carnitine Supplementation in Preterm Neonates

Recruiting·MMuhammad Aamir Latif·N/A·NCT07437391·160 enrolled

Driving1 trial

Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies.

Completed·UUniversity Hospital, Caen·N/A·NCT01231828·55 enrolled

Pregnancy1 trial

Adding L-carnitine in Clomiphene Resistant Polycystic Ovary Improves the Quality of Ovulation and the Pregnancy Outcome

Unknown status·WWoman's Health University Hospital, Egypt·Phase 4·NCT01665547·157 enrolled

CAR1 trial

Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men

Active, not recruiting·SSouth Valley University·Phase 3·NCT07402759·50 enrolled

Hypothyroidism1 trial

Effects of L-carnitine on Hypothyroidism

Completed·KKorea University Anam Hospital·Phase 4·NCT01769157·60 enrolled

Gastrointestinal Stromal Tumor1 trial

L-carnitine vs Placebo for the Treatment of Muscle Cramps After Imatinib in Gastrointestinal Stromal Tumors

Completed·—·Phase 3·NCT03426722·4 enrolled

Neurodevelopment1 trial

Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants

Completed·MMontefiore Medical Center·Phase 2/3·NCT01783041·144 enrolled

Spinal Cord Injury1 trial

The Effects of L-carnitine on Fatigue in Spinal Cord Injury

Completed·UUniversity of British Columbia·Phase 2·NCT01232907·2 enrolled

Non-Alcoholic Steatohepatitis1 trial

Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis

Unknown status·TTehran University of Medical Sciences·Phase 2·NCT01617772·440 enrolled

Post-Operative Atrial Fibrillation1 trial

Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures

Completed·—·Phase 3·NCT01107730·33 enrolled

Type 1 Diabetic1 trial

Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardioprotective Drugs

Completed·TTanta University·N/A·NCT03660293·150 enrolled

Chemotherapy1 trial

Evaluation of the Cardioprotective Effect of L-carnitine and Silymarin in Patients Receiving Anthracycline Chemotherapy

Completed·HHorus University·Phase 4·NCT04434404·83 enrolled

Chronic Hepatitis1 trial

Study to Assess Efficacy of Besifovir and L-carnitine in Chronic Hepatitis B Patients With Nonalcoholic Fatty Liver

Unknown status· IlDong Pharmaceutical Co Ltd logo

IlDong Pharmaceutical Co Ltd·Phase 4·NCT03604016·76 enrolled

Sepsis1 trial

L-Carnitine Administration in Early Sepsis

Terminated·WWake Forest University Health Sciences·Phase 1·NCT01193777·31 enrolled

Polycystic Ovary Syndrome1 trial

Adding L-Carnitine to Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome

Completed·—·Phase 4·NCT03630341·150 enrolled

Metabolism1 trial

L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients

Unknown status·KKochi University·Phase 2/3·NCT03021876·80 enrolled

Asthma1 trial

The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

Unknown status·TTanta University·Phase 3·NCT05632549·66 enrolled

Respiratory Failure1 trial

High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.

Completed·—·Phase 4·NCT05322447·60 enrolled

Women1 trial

L-carnitine and COH in PCOS Women Undergoing IVF/ICSI Cycles

Completed·RRoyan Institute·N/A·NCT04672720·110 enrolled

Respiratory Distress Syndrome1 trial

Effects of L-Carnitine Supplementation on Respiratory Distress Syndrome

Withdrawn·—·Phase 4·NCT03630367

Breast Cancer1 trial

Ability of L-carnitine to Prevent Heart Damage in Breast Cancer Patients Receiving Anthracycline Chemotherapy

Terminated·OOttawa Heart Institute Research Corporation·Phase 2/3·NCT00247975·36 enrolled

Osteoarthritis1 trial

Effect of L-carnitine on Disease Activity in Patients With Mild to Moderate Knee Osteoarthritis

Completed·—·Phase 2·NCT06960694·66 enrolled

Nephropathy1 trial

Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration

Terminated·—·Phase 3·NCT01786824·9 enrolled

Epilepsy1 trial

The Effect of Carnitine Supplementation on Cardiac Function and Lipid Profile in Patients With Drug Resistant Epilepsy on Ketogenic Diet

Unknown status·—·Phase 1·NCT06198803·52 enrolled

Multiple Sclerosis1 trial

Efficacy of L-carnitine Versus Placebo in the Treatment of Fatigue in Multiple Sclerosis

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT01149525·59 enrolled

PCOS1 trial

N-Acetylcysteine and L-carnitine in Pcos

Completed·ZZagazig University·Phase 2·NCT03164421·164 enrolled

Poisoning1 trial

L-Carnitine as an Adjuvant Treatment in Acute Phosphide Poisoning (LC)

Completed·HHeba Allah Ali Abd El-Halim Mabrouk·Phase 1·NCT03953248·50 enrolled

Rheumatoid Arthritis1 trial

L-carnitine in Modulating Pain and Inflammation in Rheumatoid Arthritis

Unknown status·TTanta University·Phase 3·NCT05792527·46 enrolled

Function1 trial

Impact on Functional Status in Older Adults Treated With L-Carnitine

Unknown status·HHospital de Clínicas Dr. Manuel Quintela·Phase 2/3·NCT03180424·60 enrolled

Hypotension1 trial

Evaluation of the Impact of L- Carnitine in Intradialytic Hypotension in Pediatric Patients on Regular Hemodialysis

Unknown status·—·Phase 3·NCT05905692·50 enrolled

Phenylketonuria1 trial

Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria

Active, not recruiting·MMansoura University·Phase 4·NCT06901323·176 enrolled

Treatment1 trial

Enhancing the Effects of Alcohol Treatment With L-Carnitine

Completed·—·Phase 1·NCT05355311·24 enrolled

Reperfusion Injury, Myocardial1 trial

Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Active, not recruiting·AAin Shams University·Phase 2·NCT06564909·76 enrolled

Diabetic Foot Ulcer1 trial

The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer.

Recruiting·AAin Shams University·Phase 2·NCT07768228·50 enrolled

Childhood Apraxia of Speech1 trial

Role of Omega-DEK in Childhood Apraxia of Speech

Not yet recruiting·CClaudia R. Morris·Phase 2·NCT07216001·34 enrolled

Hepatic1 trial

Evaluation of the Clinical Impact of Adjunctive L-carnitine Therapy in Critically Ill Hepatic Patients Admitted to Intensive Care Unit

Recruiting·BBeni-Suef University·Approved·NCT07642076·58 enrolled

Idiopathic Oligoasthenoteratozoospermia1 trial

Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia: A Three-Arm Randomized Clinical Trial.

Completed·TTehran University of Medical Sciences·Preclinical·NCT07669402·90 enrolled

Sources

References

[1]
ClinicalTrials.gov — 52 trial records for L-carnitine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — L-carnitine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for L-carnitine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Iperboreal Pharma Srl company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: IIperboreal Pharma Srl

L-carnitine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q3 2027

Q4 2027

Trials by Indication[1]

Fatigue3 trials

Peritoneal Dialysis2 trials

Anemia2 trials

Dialysis Patients2 trials

Hemodialysis2 trials

Toxicity1 trial

Varicocelectomy1 trial

Body Weight1 trial

Pyelonephritis1 trial

Pre-Term1 trial

Driving1 trial

Pregnancy1 trial

CAR1 trial

Hypothyroidism1 trial

Gastrointestinal Stromal Tumor1 trial

Neurodevelopment1 trial

Spinal Cord Injury1 trial

Non-Alcoholic Steatohepatitis1 trial

Post-Operative Atrial Fibrillation1 trial

Type 1 Diabetic1 trial

Chemotherapy1 trial

Chronic Hepatitis1 trial

Sepsis1 trial

Polycystic Ovary Syndrome1 trial

Metabolism1 trial

Asthma1 trial

Respiratory Failure1 trial

Women1 trial

Respiratory Distress Syndrome1 trial

Breast Cancer1 trial

Osteoarthritis1 trial

Nephropathy1 trial

Epilepsy1 trial

Multiple Sclerosis1 trial

PCOS1 trial

Poisoning1 trial

Rheumatoid Arthritis1 trial

Function1 trial

Hypotension1 trial

Phenylketonuria1 trial

Treatment1 trial

Reperfusion Injury, Myocardial1 trial

Diabetic Foot Ulcer1 trial

Childhood Apraxia of Speech1 trial

Hepatic1 trial

Idiopathic Oligoasthenoteratozoospermia1 trial

References

Drug Info

Quick Facts

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