Local anaesthetic

Phase 1Small molecule

CCali Pharmaceuticals LLC

Local anaesthetic is one of 64 small molecule programs targeting Arthritis. It is currently in Phase 1.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

ArthritisActive, not recruiting

PulpitisActive, not recruiting

ArthritisPhase 1

Active, not recruiting

PulpitisPreclinical

Active, not recruiting

Competition

Competitive Landscape

159 competitors in Arthritis

#DrugCompanyPhaseTrials

Cosentyx

Novartis

Phase 3

9 2

Simponi

Johnson & Johnson

Phase 3

6 3

Aleve

Alnylam Pharmaceuticals

Phase 3

4 4

Stelara

Johnson & Johnson

Phase 3

3 5

Bimzelx

UCB

Phase 3

2 6

Remicade

OOrganon and Co

Phase 3

3 7

Toradol

JJavelin Pharmaceuticals

Phase 3

1 8

Tanezumab

Pfizer

Phase 3

2 9

SHR-1314

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Phase 3

1 10

SHR0302

RReistone Biopharma Company Limited

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 1Active, not recruiting

Arthritis

NCT05747469

Clinical

Trials by Indication[1]

Enhanced Recovery After Surgery1 trial

Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)

Completed·UUniversity of California, Los Angeles·Phase 4·NCT04171050·44 enrolled

Local Anesthesia1 trial

Local Anesthesia in Radial Catheterization

Unknown status·HHippocration General Hospital·Phase 4·NCT03072394·444 enrolled

Oocyte Retrieval1 trial

Interest of Hypnosis in Virtual Reality on Nociception During Oocyte Retrieval in a Medically Assisted Reproduction Procedure

Completed·CClinique Mutualiste la Sagesse·N/A·NCT05567315·182 enrolled

Pediatric Patients1 trial

Local Anesthesia With Computerized Device for Restorative Procedures in Pediatric Patients

Completed·UUniversity of Pavia·N/A·NCT05531435·30 enrolled

Arthritis1 trial

Use of Allograft Adipose Matrix for Small Joint Arthritis of the Hand

Active, not recruiting·—·Phase 1·NCT05747469·34 enrolled

8 more indications

Pulpitis1 trial

Comparative Evaluation of Pulpal Anaesthetic Efficacy of Different Anaesthetic Solutions for Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis

Completed·—·N/A·NCT05239078·120 enrolled

Ultrasound1 trial

Assessement of a Novel Approach to Ultrasound-guided Brachial Plexus Blockade

Unknown status·UUniversity of Liege·N/A·NCT03653000·20 enrolled

General Anesthesia1 trial

General Anesthesia With or Without Local Ear Block in Middle Ear Surgeries

Completed·AAbd-Elazeem Abd-Elhameed Elbakry·N/A·NCT03569046·80 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Ultrasound Guided Adductor Canal Versus Femoral Nerve Blocks for Anterior Cruciate Ligament Reconstruction in Pediatrics

Completed·—·N/A·NCT03053401·52 enrolled

Cardiovascular1 trial

The Cardiovascular Changes Associated With Septal Local Anaesthesia

Completed·SSheffield Teaching Hospitals NHS Foundation Trust··NCT03137615·15 enrolled

Bupivacaine1 trial

Bupivacaine, Levobupivacaine and Ropivacaine After Intrathecal and Extradural Injection in Labour

Terminated·NNHS Tayside·Phase 4·NCT01201213·14 enrolled

Regional Anesthesia1 trial

Regional Anesthesia for Totally Awake Upper Limb Surgery in PEDiatric Population

Completed·RRamsay Générale de Santé·Phase 4·NCT04846855·100 enrolled

Post Operative Pain1 trial

Herniorrhaphy for Postoperative Pain

Completed·CCali Pharmaceuticals LLC·Phase 3·NCT05813847·518 enrolled

Sources

References

[1]
ClinicalTrials.gov — 13 trial records for Local anaesthetic. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Local anaesthetic compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Local anaesthetic. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Cali Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 1[1]
Company: CCali Pharmaceuticals LLC

Local anaesthetic

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Trials by Indication[1]

Enhanced Recovery After Surgery1 trial

Local Anesthesia1 trial

Oocyte Retrieval1 trial

Pediatric Patients1 trial

Arthritis1 trial

Pulpitis1 trial

Ultrasound1 trial

General Anesthesia1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Cardiovascular1 trial

Bupivacaine1 trial

Regional Anesthesia1 trial

Post Operative Pain1 trial

References

Drug Info

Quick Facts

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