Xylocaine

Phase 3Small molecule

AstraZeneca

Xylocaine is one of 11 small molecule programs targeting Plantar Fasciitis. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Plantar FasciitisActive, not recruiting

Post Operative Sore ThroatActive, not recruiting

Plantar FasciitisPreclinical

Active, not recruiting

Post Operative Sore ThroatPhase 3

Active, not recruiting

Competition

Competitive Landscape

10 competitors in Plantar Fasciitis

#DrugCompanyPhaseTrials

Medrol

Pfizer

Approved

1 2

Marcaine

Xylocaine

1 4

Xylocaine

CCitius Pharmaceuticals, Inc.

Botox

1 6

Xylocaine

Platelet Rich Plasma

2 8

Platelet-Rich Fibrin (PRF)

FFederal University of São Paulo

Preclinical

1 9

Cortisone Acetate

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 10

Bone Marrow Aspirate

WWashington University School of Medicine

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

ApprovedRecruiting

Surgery

NCT05285566

Clinical

Trials by Indication[1]

Midazolam2 trials

Intranasal Midazolam in Children as a Pre-Operative Sedative

Completed·BBassett Healthcare·Phase 4·NCT02314546·15 enrolled

Intranasal Midazolam in Children as a Pre-Operative Sedative - Part 2

Completed·JJennifer Victory, RN, CCRC·Phase 4·NCT02356705·42 enrolled

Lidocaine2 trials

Pain With Trigger Finger Injection: A Comparison of Steroid Alone Versus Steroid/Lidocaine Mixture

Terminated·—·Phase 4·NCT02421419·26 enrolled

Effect of Adding Dexamethasone to Lidocaine in Scalp Incision Infiltration for Craniotomy

Completed·AAssiut University·Preclinical·NCT07788261·100 enrolled

Anesthesia1 trial

Comparison Between Two Different Volumes of Anesthesia Drug in Forearm Surgery

Completed·UUniversity Hospital, Brest·Phase 3·NCT01216488·72 enrolled

Plantar Fasciitis1 trial

Ultrasound-guided Pulsed Radiofrequency for Plantar Fasciitis

Completed·YYung-Tsan Wu·N/A·NCT02242513·36 enrolled

Upper Extremity Pain1 trial

Treatment of Chronic Thoracic and Neck and Upper Extremity Pain

Completed·PPain Management Center of Paducah·Phase 4·NCT01071369·120 enrolled

11 more indications

Laparoscopy1 trial

The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy

Completed·UUniversity Hospital, Lille·Phase 2/3·NCT02969733·135 enrolled

Postoperative Analgesia1 trial

Comparison of Bupivacaine Versus Bupivacaine-dexamethasone Infiltration for Postoperative Analgesia in Skin Graft Donor Sites

Completed·—·Phase 4·NCT03967392·100 enrolled

Carpal Tunnel Syndrome1 trial

Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome

Unknown status·TTaipei Medical University Hospital·Phase 2/3·NCT02870673·72 enrolled

Sore Throat1 trial

Sore Throat Prevention Following Intubation

Completed·UUniversity of Jordan·Phase 4·NCT02682134·300 enrolled

Neuroma1 trial

A Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine)

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01298310·27 enrolled

Clinical Trial1 trial

A Clinical Trial of Cutaneous Xylocaine Spray to Reduce Intravenous Cannulation Pain in Adults

Completed·IIsala·Phase 4·NCT02562144·17 enrolled

Spinal Fusion1 trial

Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery

Completed·UUniversity of Puerto Rico·Phase 4·NCT05413902·100 enrolled

Pain Control1 trial

Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy

Completed·MMansoura University·Phase 4·NCT03032458·165 enrolled

Post Operative Sore Throat1 trial

Air Versus Lignocaine for Endotracheal Tube Cuff Inflation and Effect on Postoperative Sore Throat and Intracuff Pressure

Active, not recruiting·PPAEC General Hospital, Islamabad·Phase 2/3·NCT07315490·80 enrolled

AIN1 trial

Xylocaine to Freeze During Unpleasant Nasopharyngeal Swabs

Completed·EEvelyne D.Trottier·Phase 2/3·NCT04901065·88 enrolled

Surgery1 trial

A Phase IV Randomized, Single-Blind Trial of Liposomal Bupivacaine (Exparel®) for Pain Control in Costal Cartilage Harvest

Recruiting·MMayo Clinic·Approved·NCT05285566·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 18 trial records for Xylocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Xylocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Xylocaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — AstraZeneca company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: AstraZeneca

Xylocaine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Trials by Indication[1]

Midazolam2 trials

Lidocaine2 trials

Anesthesia1 trial

Plantar Fasciitis1 trial

Upper Extremity Pain1 trial

Laparoscopy1 trial

Postoperative Analgesia1 trial

Carpal Tunnel Syndrome1 trial

Sore Throat1 trial

Neuroma1 trial

Clinical Trial1 trial

Spinal Fusion1 trial

Pain Control1 trial

Post Operative Sore Throat1 trial

AIN1 trial

Surgery1 trial

References

Drug Info

Quick Facts

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