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Ansaid

(flurbiprofen)

ApprovedSmall molecule

PPharmacia and Upjohn

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. It works by blocking the body's production of substances that cause pain, fever, and inflammation.[2] Ansaid is currently approved and in use across 17 indications[4].[1]

Ansaid is one of 358 small molecule programs targeting Myalgia. It is currently in Approved.

17

Indications

34

Total Trials

4

Active Trials

357

Competitors

2

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

MyalgiaActive, not recruiting

Rheumatoid ArthritisActive, not recruiting

Eye InflammationActive, not recruiting

MiosisActive, not recruiting

OsteoarthritisActive, not recruiting

ArthralgiaActive, not recruiting

Rheumatic DiseaseActive, not recruiting

Anemia (phenotype)Approved

PeriodontitisApproved

Low Back PainApproved

MyalgiaApproved

Active, not recruiting

Rheumatoid ArthritisApproved

Active, not recruiting

Eye InflammationApproved

Active, not recruiting

MiosisApproved

Active, not recruiting

OsteoarthritisPreclinical

Active, not recruiting

ArthralgiaApproved

Active, not recruiting

Rheumatic DiseaseApproved

Active, not recruiting

Anemia (phenotype)Approved

Approved

PeriodontitisApproved

Approved

Low Back PainApproved

Approved

Showing 10 of 15 indications

Competition

Competitive Landscape

181 competitors in Rheumatoid Arthritis

#DrugCompanyPhaseTrials

Ansaid

PPharmacia and Upjohn

Actos

Celexa

Cataflam

Plaquenil

Jazz Pharmaceuticals

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Velcade

SShilpa Grover, MD, MPH

Vancocin

HHikma Pharmaceuticals LLC

Disalcid

JJoslin Diabetes Center

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

N/AActive, not recruiting

Post Operative Sore Throat

NCT07163429

Q4 2027

Phase 2Not yet recruiting

Pain Management

NCT07826806

Clinical

Trials by Indication[1]

Interaction8 trials

Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults

Completed· GSK logo

GSK·Phase 1·NCT04425902·20 enrolled

A Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05852769·18 enrolled

Drug-drug Interaction Study of KL1333 in Healthy Subjects

Completed·AAbliva AB·Phase 1·NCT04643249·14 enrolled

Show 5 more trials

Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs

Completed· GSK logo

GSK·Phase 1·NCT00920088·24 enrolled

Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants

Completed·IInstitut de Recherches Internationales Servier (I.R.I.S.)·Phase 1·NCT07235748·28 enrolled

Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation

Completed· GSK logo

GSK·Phase 1·NCT00964106·87 enrolled

Voxelotor CYP and Transporter Cocktail Interaction Study

Completed· Pfizer logo

Pfizer·Phase 1·NCT05981365·44 enrolled

A Phase 1 Drug-drug Interaction Study in Healthy Volunteers

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02227173·20 enrolled

Oral2 trials

To Assess the Bioavailability of TK-254RX in Comparison with Oral Flurbiprofen Tablets and the Adhesion of TK-254RX in Healthy Subjects

Completed·TTeikoku Seiyaku Co., Ltd.·Phase 1·NCT06823284·26 enrolled

Oral Flurbiprofen Spray for Mucosal Graft Harvesting at the Palatal Area

Completed·GGazi University·Phase 1·NCT03165929·48 enrolled

Pharyngitis2 trials

A Study of Flurbiprofen 8.75 mg Lozenge in Patient With Pharyngitis

Completed·RReckitt Benckiser LLC·Phase 3·NCT01049334·204 enrolled

A Study of Flurbiprofen 8.75 mg Lozenge in Patients With Pharyngitis

Completed·RReckitt Benckiser LLC·Phase 3·NCT01048866·198 enrolled

Methotrexate1 trial

Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03131973·26 enrolled

Metabolism1 trial

The Effects of NSAIDs on Bone Metabolism Following Exercise

Completed·—·Phase 1·NCT05512013·12 enrolled

20 more indications

Respiratory tract infection1 trial

Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients with Upper Respiratory Tract Infections

Completed·UUniversity of Melbourne·Phase 1·NCT05955885·101 enrolled

Spinal Cord Injury1 trial

Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury

Not yet recruiting·—·N/A·NCT06531837·60 enrolled

Tooth Extraction1 trial

Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

Completed·NNational Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00001724·100 enrolled

Sedation1 trial

Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients

Completed·PPeking University·Phase 4·NCT04602845·81 enrolled

TED1 trial

CYP2C9 Activity Evaluated With a Simple Finger Prick

Completed·UUniversity Hospital, Geneva·Phase 1/2·NCT01026714·10 enrolled

Adult1 trial

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT07223671·32 enrolled

Post Operative Sore Throat1 trial

Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation

Active, not recruiting·KKittitorn Supphapipat, MD·N/A·NCT07163429·58 enrolled

Midazolam1 trial

A Study to Investigate the Effect of Single and Repeated Oral Doses of ACT-539313 on What the Body Does to Flurbiprofen, Omeprazole, Midazolam in Healthy Subjects

Completed· Idorsia Pharmaceuticals Ltd. logo

Idorsia Pharmaceuticals Ltd.·Phase 1·NCT05254548·22 enrolled

Mucositis1 trial

Microbiome Shift in Peri-mucositis by Anti-inflammatory Drugs

Unknown status·PPolak David·Phase 1·NCT03090009·100 enrolled

Wounds1 trial

Flurbiprofen Tablet vs Spray In Oral Soft Tissue Wounds

Completed·YYuzuncu Yil University·Phase 4·NCT06238154·40 enrolled

Single Dose1 trial

A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05932277·22 enrolled

Amputation1 trial

Comparison of Two Kinds of Postoperative Analgesia After Amputation

Unknown status·GGuangzhou General Hospital of Guangzhou Military Command·Phase 4·NCT02114463·36 enrolled

Shivering1 trial

Effect of Parecoxib Sodium and Flurbiprofen Injection on Postoperative Shivering

Completed·GGuangxi Medical University·Phase 4·NCT02569905·166 enrolled

Chronic Periodontitis1 trial

The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis

Completed·DDexcel Pharma Technologies Ltd.·Phase 2·NCT01040286

Quality of Life1 trial

Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life

Completed·NNear East University, Turkey·Phase 4·NCT03745599·60 enrolled

Tracheal Intubation1 trial

Oro-tracheal Intubation: Flurbiprofen Subglottic Instillation to Prevent Laryngeal Inflammation

Unknown status·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·Phase 2·NCT04708964·70 enrolled

Patient-Controlled Analgesia1 trial

The Comparison of the Analgesic Effects of Dezocine and Sufentanil in Patient-controlled Analgesia After Laryngectomy

Completed·EEye & ENT Hospital of Fudan University·N/A·NCT06000137·129 enrolled

Adult Subject1 trial

Effect of GSK376501 on CYP450 Activity in Healthy Adult Subjects

Completed· GSK logo

GSK·Phase 1·NCT00615212·23 enrolled

Pain Management1 trial

Efficacy and Safety of Anrikefon Injection for the Treatment of Postoperative Pain in Patients Undergoing Laparoscopic Hepatectomy--A Single-center, Randomized, Controlled Clinical Study

Not yet recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT07826806·108 enrolled

Unspecified1 trial

Placebo-Controlled Onset-of-Action Study of Flurbiprofen Utilizing the Double-Stopwatch Method

Completed·RReckitt Benckiser LLC·Phase 3·NCT01986361·122 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 31, 1986

OCUFEN

NDA NDA019404

Oct 31, 1988

ANSAID

NDA NDA018766

Sources

References

[1]
ClinicalTrials.gov — 34 trial records for flurbiprofen. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Ansaid drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — flurbiprofen compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for flurbiprofen. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA018766). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Pharmacia and Upjohn company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Cyclooxygenase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPharmacia and Upjohn

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