Minocin

(Minocycline)

ApprovedSmall molecule

Minocycline is an antibiotic used to treat bacterial infections like acne, urinary tract infections, and certain sexually transmitted infections. It can also be used to treat some inflammatory conditions.[2] Minocin is currently approved and in use across 93 indications[4].[1]

Minocin is one of 1867 small molecule programs targeting Glioma. It is currently in Approved.

Indications

156

Total Trials

Active Trials

1,866

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

GliomaActive, not recruiting

Cerebral Amyloid AngiopathyApproved

HIV InfectionApproved

Bacterial DiseaseActive, not recruiting

PneumothoraxApproved

Oral Lichen PlanusActive, not recruiting

Depressive DisorderApproved

Oropharynx CancerActive, not recruiting

Peri-ImplantitisApproved

Cerebral Arteriovenous MalformationActive, not recruiting

GliomaPhase 1/Phase 2

Active, not recruiting

Cerebral Amyloid AngiopathyApproved

Approved

HIV InfectionApproved

Approved

Bacterial DiseasePhase 2

Active, not recruiting

PneumothoraxApproved

Approved

Oral Lichen PlanusPhase 3

Active, not recruiting

Depressive DisorderApproved

Approved

Oropharynx CancerPhase 2

Active, not recruiting

Peri-ImplantitisApproved

Approved

Cerebral Arteriovenous MalformationPhase 1

Active, not recruiting

Showing 10 of 93 indications

Competition

Competitive Landscape

1639 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Minocin

Yervoy

31 3

Gemzar

GGynecologic Oncology Group

Preclinical

72 4

Ofev

Boehringer Ingelheim

Preclinical

7 5

Immunotherapy

Bristol-Myers Squibb

Preclinical

12 6

Remeron

OOrganon and Co

Preclinical

1 7

PD-1 Inhibitor

Johnson & Johnson

Preclinical

2 8

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Vidaza

1 10

Huaier Granule

QQidong Gaitianli Medicines Co., Ltd

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Not yet recruiting

Sickle Cell Disease

NCT05605366

Phase 1/2Recruiting

Uveitis

NCT05474729

Q3 2027

N/ARecruiting

Morbid Obesity

NCT06537921

Q1 2028

Phase 2Not yet recruiting

Atrial Fibrillation

NCT01422148

Q2 2028

Phase 3Not yet recruiting

Retinitis Pigmentosa

NCT07082855

Clinical

Trials by Indication[1]

Minocycline25 trials

An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence

Unknown status·UUniversiti Sains Malaysia·Phase 3·NCT02541500·40 enrolled

Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection

Unknown status·MMahidol University·Phase 4·NCT05586815·94 enrolled

Open Treatment of Minocycline in Geriatric Depression

Completed·WWeill Medical College of Cornell University·N/A·NCT01659320·16 enrolled

Show 22 more trials

Minocycline to Reduce Pain After Carpal Tunnel Release

Completed·VVA Palo Alto Health Care System·Phase 2·NCT02051296·131 enrolled

Open Label Photo-Documentation Study Of BPX-01 Minocycline Gel

Completed·BBioPharmX, Inc.·Phase 2·NCT02946788·20 enrolled

Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin

Terminated·DDerm Research @ 888 Inc.·Phase 4·NCT00240513·38 enrolled

Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States

Completed·PPakistan Institute of Living and Learning·Phase 2·NCT02569307·326 enrolled

Evaluation of Neuroprotective Effect of Minocycline

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2·NCT01297816

Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults

Terminated·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT00361257·107 enrolled

The Effects of Minocycline in Humans

Completed·YYale University·Phase 1·NCT02193269·10 enrolled

Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01906008·122 enrolled

Minocycline in Clinically Isolated Syndromes (CIS)

Completed·—·Phase 3·NCT00666887·142 enrolled

Minocycline Bioequivalence Study

Completed· GSK logo

GSK·Phase 1·NCT01938508·28 enrolled

Effect of Minocycline on Pain Caused by Nerve Damage

Completed·ZZiekenhuis Oost-Limburg·Phase 4·NCT01869907·60 enrolled

Minocycline Pharmacokinetics (ACUMIN)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT03369951·58 enrolled

Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression

Unknown status·SShalvata Mental Health Center·Phase 1·NCT01574742·30 enrolled

Minocycline's Effects on Alcohol Responses in Humans

Completed·YYale University·Phase 1·NCT02187211·54 enrolled

Minocycline Augmentation to Clozapine

Completed·EEmory University·Phase 4·NCT02124811·10 enrolled

Study 3: Minocycline Decreases Microglia Activation

Completed·UUniversity of Florida·Phase 2·NCT02213575·5 enrolled

The Effects of Minocycline in Opioid-maintained Patients

Completed·YYale University·N/A·NCT02359006·27 enrolled

Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline

Unknown status·SState University of New York - Downstate Medical Center·Phase 2·NCT04202263·25 enrolled

Bioequivalecne Study of Minocycline 100mg Tablets Under Fed Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00777413·24 enrolled

Minocycline in MS: Confirmation of Benefit

Terminated·UUniversity of Calgary·Phase 3·NCT04291456·9 enrolled

Bioequivalence Minocycline Bioequivalence

Completed· GSK logo

GSK·Phase 1·NCT01755611·25 enrolled

A Study to Examine the Effects of Minocycline Extended-Release Tablets on Sperm Production in Human Males.

Completed·MMedicis Pharmaceutical Corporation·Phase 4·NCT00765336·180 enrolled

Schizophrenia11 trials

Adjunctive Minocycline in Clozapine Treated Schizophrenia Patients

Completed·UUniversity of Maryland, Baltimore·N/A·NCT01433055·52 enrolled

Minocycline Augmentation in Schizophrenia

Unknown status·TThe University of Texas Health Science Center, Houston·N/A·NCT01561742·120 enrolled

The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia

Completed·—·Phase 4·NCT01493622·78 enrolled

Show 8 more trials

Minocycline for the Treatment of Early-Phase Schizophrenia

Completed·SShalvata Mental Health Center·Phase 3·NCT00733057·70 enrolled

The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms

Completed·UUniversity of Manchester·Phase 2·NCT02928965·207 enrolled

Minocycline for Schizophrenia

Completed·—·Phase 4·NCT01809158·150 enrolled

Minocycline as an Adjunctive Therapy for Schizophrenia: a Randomized Controlled Study

Unknown status·SShalvata Mental Health Center·Phase 4·NCT01133080·50 enrolled

Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia

Unknown status·PPakistan Institute of Living and Learning·Phase 1·NCT02533232·60 enrolled

Minocycline and Tobacco Craving in Smokers With Schizophrenia

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT02968602·32 enrolled

Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia

Unknown status·—·Phase 3·NCT02907437·40 enrolled

Anti-inflammatories and Adolescent Schizophrenia

Unknown status·HHospital Psiquiatrico Infantil Dr. Juan N. Navarro, Mexico·Phase 4·NCT04020588·90 enrolled

Stroke5 trials

National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial

Completed·UUniversity of Rochester·Phase 2·NCT00063193·195 enrolled

Maimonides Minocycline in Stroke Study

Terminated·MMaimonides Medical Center·Phase 2/3·NCT06107725·2 enrolled

Enoxaparin and/or Minocycline in Acute Stroke

Terminated·NNYU Langone Health·N/A·NCT00836355·6 enrolled

Show 2 more trials

Minocycline in Stroke Study at Maimonides

Recruiting·JJoyce Chen·Phase 2/3·NCT07237048·1,164 enrolled

Neuroprotection With Minocycline Therapy for Acute Stroke Recovery Trial

Terminated·SSinghealth Foundation·Phase 4·NCT00930020·139 enrolled

Bipolar Depression5 trials

Minocycline for Bipolar Depression

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT01514422·20 enrolled

A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression

Suspended·MMassachusetts General Hospital·Phase 4·NCT02719392·40 enrolled

Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression

Completed·PPakistan Institute of Living and Learning·Phase 3·NCT02703363·265 enrolled

Show 2 more trials

Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression

Completed·UUniversity Health Network, Toronto·Phase 3·NCT01403662·29 enrolled

Minocycline and Aspirin in the Treatment of Bipolar Depression

Completed·LLaureate Institute for Brain Research, Inc.·Phase 3·NCT01429272·99 enrolled

Ischemic stroke4 trials

Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy

Recruiting·XXijing Hospital·Phase 4·NCT05487417·180 enrolled

Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)

Active, not recruiting·XXijing Hospital·Phase 4·NCT05512910·90 enrolled

Neuroprotection in Acute Ischemic Stroke

Completed·SStony Brook University·Phase 2/3·NCT03320018·15 enrolled

Show 1 more trial

Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke

Completed·—·Phase 1/2·NCT00630396·60 enrolled

82 more indications

Intracerebral Hemorrhage4 trials

Use of Minocycline in Intracerebral Hemorrhage

Completed·UUniversity of Tennessee·Phase 1/2·NCT03040128·20 enrolled

A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients

Completed·—·Phase 1/2·NCT01805895·16 enrolled

Efficacy and Safety of Minocycline in the Treatment of Intracerebral Hemorrhage

Not yet recruiting·TThe First Hospital of Jilin University·N/A·NCT07305896·1,248 enrolled

Show 1 more trial

Minocycline Accelerates Intracerebral Hemorrhage Absorption

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1·NCT05630534·90 enrolled

Autism3 trials

A Proof-of-Concept Study of Minocycline in Autism

Completed·—·Phase 1·NCT04031755·53 enrolled

Minocycline to Treat Childhood Regressive Autism

Completed·NNational Institute of Mental Health (NIMH)·Phase 4·NCT00409747·11 enrolled

Measuring Brain Inflammation in Autism

Suspended·UUniversity of California, Los Angeles·Phase 1·NCT03117530·30 enrolled

Rosacea3 trials

Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea

Enrolling by invitation·SSecond Affiliated Hospital of Xi'an Jiaotong University·Phase 4·NCT06307288·45 enrolled

Topical Minocycline Gel for Inflammatory Lesions of Papulopustular Rosacea

Unknown status·BBioPharmX, Inc.·Phase 2·NCT03667222·207 enrolled

Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea

Completed·DDermatology Specialists Research·Phase 4·NCT05014906·60 enrolled

Small Cell Lung Cancer3 trials

A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil

Completed·MM.D. Anderson Cancer Center·N/A·NCT01317550·14 enrolled

Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01636934·51 enrolled

Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC)

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT01048983

Delirium2 trials

Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium

Unknown status·RRenJi Hospital·Phase 3·NCT02928692·750 enrolled

Effect of Minocycline on Delirium Incidence in Critically Ill Patients

Completed·UUniversidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude·Phase 2·NCT04219735·160 enrolled

Treatment Resistant Depression2 trials

Minocycline As Adjunctive Treatment for Treatment Resistant Depression

Completed·CCentre for Addiction and Mental Health·Phase 3·NCT03947827·76 enrolled

Adjunct Minocyline in Treatment-resistant Depression

Completed·—·Phase 2·NCT02456948·168 enrolled

Head and Neck Cancer2 trials

Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT02055963·30 enrolled

Symptom Burden in Head and Neck Cancer

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT01219673·1 enrolled

Asthma2 trials

Open-Label Trial of the Use of Minocycline in the Treatment of Asthma

Completed·SState University of New York - Downstate Medical Center·Phase 2·NCT00536042·14 enrolled

Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma

Completed·SState University of New York - Downstate Medical Center·Phase 2·NCT00456677·20 enrolled

Concentration2 trials

Administration of Oral Extended Release Minocycline for Assessment of Skin and Plasma Concentrations of Minocycline

Completed·BBioPharmX, Inc.·Phase 4·NCT02695446·12 enrolled

Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV

Withdrawn· Novartis logo

Novartis·Phase 1·NCT03291158

Retinal Vein Occlusion2 trials

Minocycline to Treat Branch Retinal Vein Occlusion

Completed·NNational Eye Institute (NEI)·Phase 1/2·NCT01468831·9 enrolled

Minocycline to Treat Central Retinal Vein Occlusion

Completed·NNational Eye Institute (NEI)·Phase 1/2·NCT01468844·6 enrolled

Huntington's Disease2 trials

Pilot Study of Minocycline in Huntington's Disease

Completed·MMerit Cudkowicz·Phase 2/3·NCT00277355·114 enrolled

Minocycline in Patients With Huntington's Disease

Completed·FFDA Office of Orphan Products Development·Phase 1/2·NCT00029874·63 enrolled

Angelman syndrome2 trials

Minocycline in the Treatment of Angelman Syndrome

Completed·UUniversity of South Florida·N/A·NCT01531582·25 enrolled

Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome

Completed·PPuerta de Hierro University Hospital·Phase 2·NCT02056665·32 enrolled

Cystoid Macular Edema2 trials

Minocycline Treatment for Cystoid Macular Edema

Unknown status·SSun Yat-sen University·Phase 1/2·NCT05474950·5 enrolled

Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa

Completed·NNational Eye Institute (NEI)·Phase 1/2·NCT02140164·7 enrolled

Spinal Cord Injury2 trials

Minocycline in Acute Spinal Cord Injury (MASC)

Unknown status·RRick Hansen Institute·Phase 3·NCT01828203·248 enrolled

Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury

Completed·UUniversity of Calgary·Phase 1/2·NCT00559494·52 enrolled

Amyotrophic Lateral Sclerosis2 trials

Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis

Completed·—·Phase 2·NCT00355576·86 enrolled

Minocycline to Treat Amyotrophic Lateral Sclerosis

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 3·NCT00047723·400 enrolled

Alcohol Use Disorder2 trials

Neuroimmune Dysfunction in Alcohol Use Disorder

Completed·UUniversity of Maryland, Baltimore·Phase 1·NCT04210713·142 enrolled

Minocycline for Alcohol Use Disorder

Withdrawn·UUniversity of California, Los Angeles·Phase 1/2·NCT03244592

Efficacy and Safety2 trials

Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment

Active, not recruiting·XXijing Hospital of Digestive Diseases·Phase 4·NCT06523764·208 enrolled

Efficacy And Safety Of Azithromycin SR Compared With Minocycline In Acne

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00392223·118 enrolled

Retinitis Pigmentosa2 trials

Minocycline Treatment in Retinitis Pigmentosa

Completed·SSun Yat-sen University·Phase 2·NCT04068207·35 enrolled

A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa

Not yet recruiting·ZZhongshan Ophthalmic Center, Sun Yat-sen University·Phase 3·NCT07082855·126 enrolled

Multiple Myeloma2 trials

Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01793051·88 enrolled

Prevention of Treatment Induced Neuropathy in Multiple Myeloma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01283997·79 enrolled

Fragile X Syndrome1 trial

Add-on Pilot Trial of Minocycline to Treat Fragile X Syndrome

Completed·FFRAXA Research Foundation·N/A·NCT00858689·20 enrolled

Inflammation1 trial

Effect of Minocycline on Inflammation in Depressed Patients

Unknown status·IIRCCS Centro San Giovanni di Dio Fatebenefratelli·Phase 2·NCT06207760·60 enrolled

Resistance1 trial

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT03489629·37 enrolled

Major Depressive Disorder1 trial

Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder

Completed·CCentre for Addiction and Mental Health·Phase 1·NCT02362529·115 enrolled

Psychosis1 trial

Role of Minocycline in First Episode Psychosis

Completed·—·Phase 1/2·NCT00916461·52 enrolled

Atrial Fibrillation1 trial

Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery

Not yet recruiting·—·Phase 2·NCT01422148·60 enrolled

Hypertension1 trial

Neuroinflammation in Hypertension Study

Unknown status·RRoyal Perth Hospital·Phase 3·NCT04478500·60 enrolled

Glioma1 trial

Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma

Completed·UUniversity of Utah·Phase 1/2·NCT01580969·22 enrolled

Bacterial Disease1 trial

Pharmacokinetic Study of Minocycline in Patients With Pulmonary Nontuberculous Mycobacterial Disease

Terminated·RRadboud University Medical Center·Phase 2·NCT05861258·12 enrolled

Obesity1 trial

Depression, Obesity and Inflammatory Markers

Completed·WWeill Medical College of Cornell University·N/A·NCT02765100·21 enrolled

Paralysis1 trial

Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement

Unknown status·HHadassah Medical Organization·Phase 2/3·NCT01813240·444 enrolled

Medication1 trial

Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD

Completed·NNew York State Psychiatric Institute·Phase 2·NCT01695291·31 enrolled

Cognitive impairment1 trial

Minocycline for HIV+ Cognitive Impairment in Uganda

Terminated·JJohns Hopkins University·Phase 1/2·NCT00855062·73 enrolled

Obsessive Compulsive Disorder (OCD)1 trial

Study of NPL-2003 in Adolescents With Obsessive Compulsive Disorder (OCD)

Terminated·NNeuropharm·Phase 2·NCT00515255·6 enrolled

Esophageal Cancer1 trial

A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01746043·22 enrolled

Periodontal Disease1 trial

Kidney and Periodontal Disease Study

Completed·UUniversity of California, San Francisco·N/A·NCT01802216·51 enrolled

Trial1 trial

Stony Brook Medicine Anti-Inflammatory Trial

Not yet recruiting·SStony Brook University·Phase 4·NCT06699966·42 enrolled

Post-Traumatic Stress Disorder1 trial

Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans

Completed·SSriram Ramaswamy·Phase 4·NCT03340350·10 enrolled

Acute Kidney Injury1 trial

Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery

Completed·—·N/A·NCT00556491·40 enrolled

Bismuth Quadruple Therapy1 trial

Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Unknown status·XXijing Hospital of Digestive Diseases·Phase 4·NCT06603688·548 enrolled

Schizoaffective Disorder1 trial

Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective Disorder

Unknown status·SSheba Medical Center·Phase 3·NCT01320982·400 enrolled

Uveitis1 trial

Minocycline for Chronic Autoimmune Uveitis

Recruiting·SSun Yat-sen University·Phase 1/2·NCT05474729·10 enrolled

Randomized Controlled Trial1 trial

Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial

Completed·PPakistan Institute of Living and Learning·Phase 4·NCT02263872·41 enrolled

Antibiotics1 trial

Antibiotics Against Amyloid Angiopathy

Unknown status·LLeiden University Medical Center·Phase 1/2·NCT05680389·60 enrolled

Neuralgia1 trial

Minocycline for the Prevention of Post-operative Intercostal Neuralgia

Unknown status·UUniversity of Adelaide·Phase 2·NCT01314482·116 enrolled

Stress1 trial

Brain and Stress Study

Completed·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT06044090·10 enrolled

Epilepsy1 trial

The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients

Unknown status·XXijing Hospital·N/A·NCT05958069·25 enrolled

Pancreatic Cancer1 trial

Minocycline Study in Pancreatic Cancer Patients

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01693523·80 enrolled

Autoimmune Encephalitis1 trial

Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis

Completed·XXijing Hospital·Phase 2·NCT06033846·60 enrolled

Rheumatoid Arthritis1 trial

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

Recruiting·UUniversity of Nebraska·Phase 3·NCT03414502·400 enrolled

Cerebral arteriovenous malformation1 trial

Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Completed·UUniversity of California, San Francisco·Phase 1·NCT00243893·26 enrolled

Diabetic Macular Edema1 trial

A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema

Completed·NNational Eye Institute (NEI)·Phase 1/2·NCT01120899·6 enrolled

Optic Neuritis1 trial

Neuroprotection and Repair in Optic Neuritis

Terminated·UUniversity of Calgary·Phase 2·NCT01073813·6 enrolled

Age-Related Macular Degeneration1 trial

Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration

Completed·NNational Eye Institute (NEI)·Phase 2·NCT02564978·37 enrolled

Tics1 trial

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54175446 in Healthy Male Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02515955·76 enrolled

Subarachnoid Hemorrhage1 trial

Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage

Withdrawn·UUniversity at Buffalo·Phase 1/2·NCT02113176

Brain Injury1 trial

Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI)

Completed·WWayne State University·Phase 1/2·NCT01058395·15 enrolled

Helicobacter Pylori Eradication1 trial

Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial

Recruiting·YYongquan Shi·Phase 4·NCT07068607·400 enrolled

Cognition1 trial

The Effect of Acute Minocycline Administration on Emotional Processing and Cognition in Healthy Volunteers

Completed·UUniversity of Oxford·N/A·NCT03768557·40 enrolled

Oral Lichen Planus1 trial

The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus

Unknown status·SSheba Medical Center·Phase 3·NCT01083420·30 enrolled

Relapsing-Remitting Multiple Sclerosis1 trial

Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS]

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT01134627·305 enrolled

Lung Cancer1 trial

Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer

Completed·BBritish Columbia Cancer Agency·Phase 2·NCT00473083·150 enrolled

Stenotrophomonas Maltophilia Infection1 trial

Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections

Unknown status·MMahidol University·Phase 4·NCT05575427·112 enrolled

Idiopathic Pulmonary Fibrosis1 trial

Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study

Unknown status·UUniversity of California, Los Angeles·Phase 3·NCT00203697

Chronic Periodontitis1 trial

The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis

Completed·ZZhejiang University·Phase 4·NCT02355977·70 enrolled

Liver Transplant1 trial

Minocycline Administration During Human Liver Transplantation

Withdrawn·MMedical University of South Carolina·Phase 4·NCT02712775

Carotid Endarterectomy1 trial

A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy

Withdrawn·—·Phase 2·NCT00401921

Alzheimer's Disease1 trial

Minocycline in Patients With Alzheimer's Disease

Completed·HHuntington Medical Research Institutes·Phase 2·NCT01463384·13 enrolled

HIV-1 infection1 trial

A Pilot Study of the Effect of Minocycline on Cerebrospinal Fluid HIV-1 Infection

Completed·UUniversity of California, San Francisco··NCT01064752·7 enrolled

Sickle Cell Disease1 trial

Minocycline in Neurocognitive Outcomes - Sickle Cell Disease

Not yet recruiting·UUniversity of Cincinnati·Phase 1·NCT05605366·30 enrolled

Trauma1 trial

Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories

Completed·PPsychiatric University Hospital, Zurich·N/A·NCT05902819·138 enrolled

Sclerosing Cholangitis1 trial

Minocycline in Primary Sclerosing Cholangitis (PSC)

Completed·MMayo Clinic·Phase 1·NCT00630942·16 enrolled

Ulcerative Colitis1 trial

Minocyclin in Ulcerative Colitis as Added on Therapy

Completed·MMostafa Bahaa·Phase 2·NCT06201793·46 enrolled

Oropharynx Cancer1 trial

Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01173692·47 enrolled

Glioblastoma1 trial

A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

Completed·UUniversity of Ulm·Phase 1/2·NCT02770378·10 enrolled

Cystic Fibrosis1 trial

Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)

Terminated·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT01349192·47 enrolled

Acute1 trial

Neurophysiological and Acute Pharmacological Studies in FXS Patients

Completed·—·Phase 1·NCT02998151·29 enrolled

Intravenous1 trial

The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression

Terminated· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01809340·29 enrolled

Radiation Effect1 trial

Minocycline Therapy for Management of Adverse Radiation Effects

Terminated·UUniversity of Pittsburgh·Phase 1·NCT02201563·1 enrolled

Morbid Obesity1 trial

Comorbid Obesity and Depression With an Anti-inflammatory Medication

Recruiting·KKing's College London·N/A·NCT06537921·35 enrolled

Periodontitis1 trial

Locally Delivered Antibiotics for the Treatment of Periodontitis

Unknown status·RRiyadh Elm University·N/A·NCT04125706·44 enrolled

Fasting Conditions1 trial

Bioequivalence Study of Minocycline 100mg Tablets Under Fasting Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00776542·28 enrolled

Carcinoma, Non-Small-Cell Lung1 trial

A Phase 2, Open-Label, Randomized Trial Evaluating the Impact of Enhanced Versus Standard Dermatologic Management on Selected Dermatologic Adverse Events Among Patients With Locally Advanced or Metastatic EGFR-Mutated NSCLC Treated First-Line With Amivantamab + Lazertinib

Active, not recruiting· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT06120140·305 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

MINOCIN

NDA NDA050445

Jan 1, 1982

MINOCIN

NDA NDA050444

Jan 1, 1982

MINOCIN

NDA NDA050315

Aug 10, 1982

MINOCYCLINE HYDROCHLORIDE

NDA NDA050451

May 31, 1990

MINOCIN

NDA NDA050649

Feb 16, 2001

ARESTIN

NDA NDA050781

May 8, 2006

SOLODYN

NDA NDA050808

Jul 11, 2012

XIMINO

NDA NDA201922

May 8, 2017

MINOLIRA

NDA NDA209269

Oct 18, 2019

AMZEEQ

NDA NDA212379

May 28, 2020

ZILXI

NDA NDA213690

Nov 1, 2024

EMROSI

NDA NDA219015

Sources

References

[1]
ClinicalTrials.gov — 156 trial records for Minocycline. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Minocin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Minocycline compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Minocycline. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA219015). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Minocin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Triax company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Bacterial 70s Ribosome Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: TTriax

Patent Landscape[6]

Patent Cliff

Mar 7, 2027

Earliest patent expiration — generic entry possible after this date

Patent #Expires

7919483Mar 7, 2027

7541347Apr 2, 2027

7544373Apr 2, 2027

8945516Oct 1, 2030

10137200Oct 1, 2030

23 more patents

8865139Oct 1, 2030

10086080Oct 1, 2030

10213512Oct 1, 2030

10517882Oct 1, 2030

10322186Oct 1, 2030

10946101Oct 1, 2030

10821187Oct 1, 2030

12138311Oct 1, 2030

10265404Oct 1, 2030

9675700Oct 1, 2030

8992896Oct 1, 2030

9084802May 12, 2031

9278105May 12, 2031

12161656May 12, 2031

9192615Nov 17, 2031

11944634Oct 16, 2032

11103517Apr 7, 2036

10398641Sep 8, 2037

10849847Sep 8, 2037

12594252Jan 7, 2039

11364212Jan 7, 2039

11191740Jan 7, 2039

10905664Jan 7, 2039