Lasix

(Furosemide)

ApprovedSmall molecule

Furosemide is a water pill that helps remove extra fluid from your body by increasing urine production, commonly used to treat swelling, high blood pressure, and heart failure.[2] Lasix is currently approved and in use across 52 indications[4].[1]

Lasix is one of 1047 small molecule programs targeting Premature Birth. It is currently in Approved.

Indications

166

Total Trials

Active Trials

1,046

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Premature BirthApproved

Blood TransfusionActive, not recruiting

Cirrhosis of LiverActive, not recruiting

Nasal PolyposisActive, not recruiting

AscitesActive, not recruiting

Cardiovascular DiseaseActive, not recruiting

Myocardial FibrosisActive, not recruiting

BronchiolitisActive, not recruiting

Bronchopulmonary DysplasiaActive, not recruiting

Orthostatic IntoleranceActive, not recruiting

Premature BirthApproved

Approved

Blood TransfusionPreclinical

Active, not recruiting

Cirrhosis of LiverApproved

Active, not recruiting

Nasal PolyposisPhase 2

Active, not recruiting

AscitesPhase 2

Active, not recruiting

Cardiovascular DiseaseApproved

Active, not recruiting

Myocardial FibrosisApproved

Active, not recruiting

BronchiolitisPhase 2

Active, not recruiting

Bronchopulmonary DysplasiaPhase 1

Active, not recruiting

Orthostatic IntolerancePreclinical

Active, not recruiting

Showing 10 of 49 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Lasix

VValidus Pharmaceuticals

Approved

1 2

Adriamycin

GGynecologic Oncology Group

Preclinical

87 3

Voltaren

Novartis

Preclinical

1 4

Blenoxane

Bristol-Myers Squibb

Preclinical

1 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 6

Nubain

AAultman Health Foundation

Preclinical

1 7

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 8

Aquasol E

NNational Eye Institute (NEI)

Preclinical

—9

Neoadjuvant Therapy

SSun Yat-sen University

Preclinical

3 10

Fentanyl Citrate

IINSYS Therapeutics Inc

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ARecruiting

Cardiac Surgical Procedures

NCT07348510

Phase 1/2Active, not recruiting

Immunity

NCT03753204

Q4 2026

N/ARecruiting

Critically Ill Patients

NCT07417969

Post-ApprovalRecruiting

Treatment

NCT06218199

Post-ApprovalRecruiting

Pulmonary Edema

NCT05276219

Q2 2027

Phase 1Active, not recruiting

Metastatic Melanoma

NCT05470283

Clinical

Trials by Indication[1]

Heart Failure31 trials

Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)

Completed·UUniversity of Palermo·Phase 3·NCT04628325·136 enrolled

Aquaresis Utility for Hyponatremic Acute Heart Failure Study

Completed·UUniversity of Southern California·Phase 4·NCT02183792·33 enrolled

Effectiveness of a Diuretic Algorithm in Clinical Stability in Heart Failure Patients

Completed·HHospital de Clinicas de Porto Alegre·N/A·NCT02068937·206 enrolled

Show 28 more trials

Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance

Terminated·SStadtspital Zürich·Phase 4·NCT05986773·13 enrolled

Protocol of Diuretics Use in Congestive Therapy in Heart Failure

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT03892148·299 enrolled

A Study of Ultra High Dose Diuretics to Treat Heart Failure

Completed·MMayo Clinic·Phase 2·NCT06036914·20 enrolled

An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT03730961·23 enrolled

Combination Diuretic Therapy for Acute Decompensated Heart Failure

Withdrawn·OOchsner Health System·Phase 4·NCT05840536

OUTpatient Intravenous LASix Trial in Reducing Hospitalization for Acute Decompensated Heart Failure

Completed·NNew York Presbyterian Brooklyn Methodist Hospital·Phase 4·NCT04691687·100 enrolled

A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)

Withdrawn·YYonsei University·N/A·NCT02047422

The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure

Unknown status·MMedical University of Warsaw·Phase 4·NCT01942109·100 enrolled

Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure

Completed·YYale University·Phase 3·NCT05093621·47 enrolled

Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot

Completed·AAdrian Hernandez·Phase 1·NCT02877095·40 enrolled

Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial

Unknown status·LLarissa University Hospital·Phase 4·NCT00937092·300 enrolled

Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure

Not yet recruiting·LLakeland Regional Health Systems, Inc.·Phase 4·NCT07263035·600 enrolled

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

Recruiting·RReprieve Cardiovascular, Inc·Phase 3·NCT06898515·400 enrolled

Value of Renal Vascular Doppler Sonography in Management of Decompensated Heart Failure

Completed·—·N/A·NCT02372292·60 enrolled

Sub-Q Versus IV Furosemide in Acute Heart Failure

Completed·JJohns Hopkins University·Phase 2/3·NCT02579057·40 enrolled

Prolonged Intravenous Therapy Versus Early Initiation of an Oral Loop Diuretic in Decompensated Heart Failure

Withdrawn·JJan Kochanowski University·Phase 2/3·NCT05652322

Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure

Completed·WWroclaw Medical University·Phase 3·NCT05962255·50 enrolled

Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction

Completed·AAdhish Agarwal·Phase 1·NCT03837470·14 enrolled

Loop Diuretics Administration and Acute Heart Failure

Completed·UUniversity of Siena·Phase 4·NCT01441245·57 enrolled

Acetazolamide or Metolazone in Acute Heart Failure

Not yet recruiting·CClinica Alemana de Santiago·N/A·NCT06273397·1,050 enrolled

Hypertonic Saline Therapy in Ambulatory Heart Failure Unit.

Completed·PPuerta de Hierro University Hospital·Phase 3·NCT04533997·167 enrolled

A Study to Investigate the Pharmacodynamic and Pharmacokinetic Interaction Between Aliskiren and Furosemide in Patients With Heart Failure

Completed· Novartis logo

Novartis·Phase 2·NCT01125514·37 enrolled

Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure.

Completed·JJohannes Grand·Phase 1/2·NCT06024889·20 enrolled

Bumetanide Versus Furosemide in Heart Failure

Withdrawn·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 3·NCT00372762

Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction

Completed·JJohns Hopkins University·Phase 4·NCT01901809·90 enrolled

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure

Withdrawn·MMontefiore Medical Center·Phase 4·NCT02767024

TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure

Completed·—·Phase 3·NCT03296813·2,973 enrolled

Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 3·NCT02689180·230 enrolled

Acute Kidney Injury7 trials

The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury

Completed·UUniversity of Chicago·N/A·NCT01275729·96 enrolled

Intra-Renal Therapy of Diuretic Unresponsive Acute Kidney Injury

Withdrawn·SSoutheast Renal Research Institute·Phase 4·NCT01073189

Outpatient Recovery From Acute Kidney Injury Requiring Dialysis

Terminated·UUniversity of California, San Francisco·Phase 4·NCT05158153·1 enrolled

Show 4 more trials

Furosemide in Early Acute Kidney Injury

Terminated·UUniversity of Alberta·Phase 2/3·NCT00978354·72 enrolled

Protocol to Assess the Severity of Acute Kidney Injury

Completed·GGeorge Washington University·N/A·NCT00673244·77 enrolled

Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass

Completed·—·N/A·NCT01709227·73 enrolled

Forced Fluid Removal in High Risk Acute Kidney Injury

Terminated·NNordsjaellands Hospital·Phase 4·NCT02458157·21 enrolled

Hypertension7 trials

Hypertension Screening and Treatment Program

Completed·UUS Department of Veterans Affairs··NCT00007592

Prevention of Severe Postpartum Hypertension

Withdrawn·IIndiana University·Phase 2·NCT02450773

Furosemide vs. Placebo for Severe Antepartum Hypertension

Completed·—·Phase 3·NCT04615624·65 enrolled

Show 4 more trials

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Recruiting·UUniversity of Delaware·Phase 4·NCT06094816·120 enrolled

Olmesartan Medoxomil in Hypertension and Renal Impairment

Completed·SSankyo Pharma Gmbh·Phase 3·NCT00151827·393 enrolled

Lasix for the Prevention of De Novo Postpartum Hypertension

Completed·—·Phase 3·NCT04752475·82 enrolled

Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension

Completed·SSao Jose do Rio Preto Medical School·Phase 4·NCT02832973·72 enrolled

Interaction6 trials

Drug to Drug Interaction Study With Ipragliflozin and Furosemide

Completed· Astellas logo

Astellas·Phase 1·NCT01611415·24 enrolled

Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide

Completed·AAkebia Therapeutics·Phase 1·NCT03801759·62 enrolled

Voxelotor CYP and Transporter Cocktail Interaction Study

Completed· Pfizer logo

Pfizer·Phase 1·NCT05981365·44 enrolled

Show 3 more trials

Drug-drug Interaction Between Digoxin, Furosemide, Metformin, and Rosuvastatin

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02231931·24 enrolled

Transporter Cocktail Mutual Interaction

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02854527·30 enrolled

Metformin and Furosemide Drug-Drug Interaction Study

Completed·AArdea Biosciences, Inc.·Phase 1·NCT02028689·23 enrolled

Congestive Heart Failure4 trials

Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure

Unknown status·HHennepin County Medical Center, Minneapolis·N/A·NCT00924014·8 enrolled

Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure

Completed·HHyogo Medical University·Phase 4·NCT00355667·320 enrolled

A Trial to Study BAY1753011 in Patients With Congestive Heart Failure

Completed· Bayer logo

Bayer·Phase 2·NCT03901729·482 enrolled

Show 1 more trial

Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure

Completed·AAspirus Heart and Vascular Institute-Research and Education·Phase 3·NCT01028170·50 enrolled

81 more indications

Dyspnea4 trials

Aerosol Inhalation Treatment for Dyspnea

Completed·—·Phase 1/2·NCT01440764·24 enrolled

Aerosol Inhalation Treatment for Dyspnea - Patients

Completed·—·Phase 1/2·NCT02524054·24 enrolled

Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients

Completed·—·Phase 3·NCT00512811

Show 1 more trial

The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respiratory Diseases

Recruiting·UUniversity Hospital Hradec Kralove·Phase 2/3·NCT06252454·102 enrolled

Chronic Kidney Disease4 trials

Loop Diuretics in Chronic Kidney Disease

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00478543·40 enrolled

The Effect of Diuretics on Mineral and Bone Disorder in Chronic Kidney Disease Patients

Unknown status·UUniversity of Sao Paulo General Hospital·N/A·NCT03082742·52 enrolled

Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease

Unknown status·—·Phase 4·NCT06203236·300 enrolled

Show 1 more trial

Furosemide Stress Test as a Predictor of Tubular Function in Chronic Kidney Disease

Unknown status·IInstituto Nacional de Cardiologia Ignacio Chavez·Phase 3·NCT02417883·100 enrolled

Treatment3 trials

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts

Recruiting·HHeart Center Research, LLC·Phase 4·NCT06218199·80 enrolled

Delayed Renal Allograft Function and Furosemide Treatment

Withdrawn·LLoma Linda University·Phase 2·NCT02312115

Trial on Treatment With Inhaled Furosemide of Preterm and Term Neonates With Transient Tachypnoea

Completed·UUniversity of Cologne·Phase 2·NCT01407848·20 enrolled

Metformin3 trials

DDI (Effect of Metformin and Furosemide on Rosuvastatin PK)

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02574845·18 enrolled

A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06504862·32 enrolled

A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05768360·6 enrolled

AIN3 trials

This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03307252·45 enrolled

Brain Relaxation With Mannitol and Furosemide

Completed·IIstanbul University·N/A·NCT02712476·47 enrolled

Furosemide vs Placebo for Brain Relaxation

Terminated·NNorthwestern University·N/A·NCT01054404·23 enrolled

Critically Ill Patients3 trials

"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"

Recruiting·JJose J Zaragoza, MD MSc·N/A·NCT07417969·56 enrolled

The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients

Unknown status·ZZiekenhuis Netwerk Antwerpen (ZNA)·N/A·NCT01072071·30 enrolled

Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients

Terminated·FFrisius Medisch Centrum·Phase 3·NCT00298454·72 enrolled

Preeclampsia2 trials

Diuretics for Postpartum High Blood Pressure in Preeclampsia

Completed·IInstituto Materno Infantil Prof. Fernando Figueira·Phase 4·NCT02163655·120 enrolled

Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound

Not yet recruiting·UUniversity of California, Irvine·Phase 4·NCT07167862·96 enrolled

Clinical Pharmacology2 trials

Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Males (Drug Interaction Study and Preliminary Regimen-Finding Study)

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 1·NCT04481789·84 enrolled

Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

Active, not recruiting· AstraZeneca logo

AstraZeneca·Phase 1·NCT06899061·41 enrolled

Nephrotic Syndrome2 trials

Amiloride in Nephrotic Syndrome

Terminated·UUniversity Hospital Tuebingen·Phase 3·NCT05079789·20 enrolled

Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome

Unknown status·MMedical University of Bialystok·N/A·NCT03750136·30 enrolled

Kidney2 trials

Measurement of Kidney Blood Flow and Oxygen Levels by MRI

Completed·WWake Forest University·N/A·NCT01318967·10 enrolled

Kidney Sodium Content in Cardiorenal Patients

Recruiting·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·N/A·NCT04170855·50 enrolled

Cutaneous Warts2 trials

Role of Intralesional Combined Injection of Furosemide and Digoxin in Cutaneous Warts at Tertiary Care Hospital in Karachi.

Enrolling by invitation·JJinnah Postgraduate Medical Centre·Phase 1·NCT06821594·40 enrolled

A Phase 2 Efficacy Study of CLS003 ICVT in Subjects With Cutaneous Warts.

Completed·MMaruho Co., Ltd.·Phase 2·NCT02333643·81 enrolled

Blood Pressure2 trials

Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure

Completed·UUniversity of Calgary·Phase 4·NCT00115726·198 enrolled

Furosemide for Accelerated Recovery of Blood Pressure Postpartum

Completed·UUniversity of Pennsylvania·Phase 2·NCT03556761·384 enrolled

Cirrhosis2 trials

A Study to Compare How Different Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Handled by the Body of Healthy People and People With Liver Cirrhosis

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·N/A·NCT05741372·28 enrolled

Bumetanide vs. Furosemide in Cirrhosis

Not yet recruiting·SStacy Johnson·Phase 3·NCT06941415·500 enrolled

Tics2 trials

Pharmacokinetics, Safety and Tolerability of Concurrent Doses of BIA 5-1058 and Furosemide

Completed·BBial - Portela C S.A.·Phase 1·NCT07173738·44 enrolled

Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP

Recruiting·NNorthwestern University·Phase 3·NCT05620784·138 enrolled

Function2 trials

Furosemide and Creatinine Tubular Stress Test in Order to Measure Proximal Tubule Residual Function

Completed·IInstituto Nacional de Cardiologia Ignacio Chavez·Phase 1·NCT05105009·50 enrolled

The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.

Completed·HHospital Civil de Guadalajara·Phase 2·NCT04393493·80 enrolled

MPA2 trials

Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients

Terminated·RRush University Medical Center·Phase 4·NCT04216784·21 enrolled

A Study To Compare Effects Of GSK189075 In Combination With Either Furosemide Or Hydrochlorothiazide

Completed· GSK logo

GSK·Phase 1·NCT00671424·48 enrolled

Recovery1 trial

Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients Recovery in the Short Term

Terminated·—·N/A·NCT02800135·93 enrolled

Nasal polyposis1 trial

Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide

Terminated·TThomas Jefferson University·Phase 2·NCT03362515·18 enrolled

Ultrasound1 trial

Furosemide Use to Fill the Bladder of Pediatric Females Awaiting Pelvic Ultrasound

Completed·—·Phase 1·NCT05098366·42 enrolled

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00535925·850 enrolled

Bronchiolitis1 trial

Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis

Completed·NNorthwell Health·Phase 2·NCT02469597·46 enrolled

Hypertensive1 trial

Postpartum Management of Gestational Hypertensive Disorders Using Furosemide

Terminated·WWright State University·Phase 4·NCT04343235·13 enrolled

Drug1 trial

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04763226·46 enrolled

Necrosis1 trial

FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU

Terminated·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT03731117·11 enrolled

Dialysis Patients1 trial

Diuretic Use in Hemodialysis Patients With Residual Renal Function

Suspended·UUniversity of Alberta·Phase 4·NCT05915286·34 enrolled

Intensive Care1 trial

The Role of Furosemide Stress Test in the Intensive Care Clinic

Recruiting·GGulhane Training and Research Hospital·N/A·NCT06765031·140 enrolled

Physical Activity1 trial

Inhaled Nebulized Furosemide & Physical Activity-Related Breathlessness

Unknown status·MMcGill University·Phase 1·NCT01851980·30 enrolled

Myocardial fibrosis1 trial

Effect of a New Formulation of Torasemide (Prolonged Release)on Myocardial Fibrosis in Patients With Heart Failure.

Completed·FFerrer Internacional S.A.·Phase 4·NCT00409942·142 enrolled

Congenital Heart Disease1 trial

Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease

Completed·—·Phase 3·NCT01628731·74 enrolled

TED1 trial

Transfusion-Associated Circulatory Overload Best Eliminated With Lasix

Completed·SSunnybrook Health Sciences Centre·Phase 1·NCT02802696·80 enrolled

Right Ventricular Dysfunction1 trial

Diuretic Vascular Filling in the Initial Management of Acute PE With Right Ventricular Dysfunction Normotensive

Completed·—·Phase 4·NCT02531581·60 enrolled

Chronic Renal Failure1 trial

Pharmacokinetic Profile and Pharmacodynamic Characteristics of a Furosemide High Dosage Formulation in Patients With Chronic Renal Failure Undergoing Peritoneal Dialysis

Completed· Sanofi logo

Sanofi·Phase 1·NCT01724788·12 enrolled

Leukemia1 trial

Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid Overload

Withdrawn·MM.D. Anderson Cancer Center·N/A·NCT01508260

Metastatic Melanoma1 trial

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT05470283·21 enrolled

Intensive Care Unit1 trial

Impact of Rational Control of Fluid Balance in the Intensive Care Unit

Completed·NNantes University Hospital·Phase 3·NCT02345681·171 enrolled

Semaglutide1 trial

A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects

Completed· Novo Nordisk logo

Novo Nordisk·Phase 1·NCT03010475·41 enrolled

Renal insufficiency1 trial

A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)

Terminated· Merck & Co. logo

Merck & Co.·Phase 1·NCT01558674·11 enrolled

Prostate Cancer1 trial

Comparison of 18F-rhPSMA-7.3 PET/CT With and Without Furosemide in Biochemical Recurrence of Prostate Cancer

Active, not recruiting·EEmory University·Phase 2·NCT05779943·20 enrolled

Complication1 trial

Furosemide and Coarctation Surgery Lung Complications

Completed·—·Phase 2·NCT03364842·56 enrolled

Critical Ill Patients1 trial

Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.

Recruiting·—·Phase 4·NCT04180397·1,000 enrolled

Hemodynamic1 trial

Effect of Repeated Dosing of Naproxcinod on Renal Hemodynamic and on Sodium Balance in Healthy Volunteers Before and After a Single Dose of Furosemide

Completed·NNicOx·Phase 1·NCT00909519·31 enrolled

Acute Myeloid Leukemia1 trial

Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients

Completed·AActinium Pharmaceuticals·Phase 1/2·NCT02575963·40 enrolled

Kidney Stones1 trial

Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser

Recruiting·UUniversity Hospital, Tours·Phase 3·NCT05916963·374 enrolled

Ascites1 trial

Metabolic Effects of Furosemide +HSS in Refractory Ascites

Completed·UUniversity of Palermo·Phase 2·NCT02821377·40 enrolled

Pulmonary Edema1 trial

Optimized Treatment of Pulmonary Edema or Congestion

Recruiting·JJohannes Grand·Phase 4·NCT05276219·1,104 enrolled

Actinic Keratosis1 trial

Topical Ionic Contra-Viral Therapy in Actinic Keratosis

Unknown status·MMaruho Co., Ltd.·Phase 2·NCT03684772·32 enrolled

Infusion1 trial

An Open Label Study to Evaluate the Impact of Duration of Subcutaneous Infusion of a Novel, pH Neutral Formulation of Furosemide (Furoscix®) on Safety and Local Skin Tolerability

Completed·SscPharmaceuticals, Inc.·Phase 1·NCT04161482·39 enrolled

Imaging1 trial

18F-DOPA II - PET Imaging Optimization

Recruiting·UUniversity of Alberta·Phase 3·NCT04706910·800 enrolled

SGLT-2 Inhibitor1 trial

SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF

Not yet recruiting·UUniversity of Palermo·Phase 4·NCT06442280·544 enrolled

Oral1 trial

Furosemide Pharmacodynamics and Pharmacokinetics After Subcutaneous or Oral Administration

Completed·SscPharmaceuticals, Inc.·Phase 1/2·NCT02350725·10 enrolled

Outcome1 trial

Effect of Furosemide on ESWL Outcomes for Renal and Ureteral Calculi

Unknown status·SShiraz University of Medical Sciences·Phase 3·NCT05270421·500 enrolled

Hemodialysis1 trial

Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT04622709·39 enrolled

Pediatric Patients1 trial

Evaluating Predictive Methods & Product Performance in Healthy Adults for Pediatric Patients, A Case Study: Furosemide

Withdrawn·YYale University·Phase 1·NCT03093090

Renal Replacement Therapy1 trial

A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy

Recruiting·—·Phase 4·NCT06229990·80 enrolled

Kidney Transplant1 trial

Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation

Recruiting·KKing Chulalongkorn Memorial Hospital·N/A·NCT03071536·180 enrolled

Breast Cancer1 trial

Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer

Not yet recruiting·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT06407401·399 enrolled

Immunity1 trial

Salt-Sensitivity and Immunity Cell Activation

Active, not recruiting·VVanderbilt University Medical Center·Phase 1/2·NCT03753204·20 enrolled

Orthostatic Intolerance1 trial

Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent

Recruiting·NNational Aeronautics and Space Administration (NASA)·N/A·NCT06467825·38 enrolled

TTN1 trial

Role of Salbutamol and Furosemide in TTN

Completed·—·Phase 3·NCT03208894·100 enrolled

Bronchopulmonary Dysplasia1 trial

Nebulized Furosemide in Premature Infants With Bronchopulmonary Dysplasia - A Cross Over Pilot Study of Its Efficacy and Safety

Withdrawn·NNYU Langone Health·Phase 1·NCT03946891

Age1 trial

Pragmatic Research on Diuretic Management in Early BPD Pilot

Completed·—·Phase 4·NCT05898022·19 enrolled

Fasting Conditions1 trial

Bioequivalence Study of Furosemide 80mg Tablets Under Fasting Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00778180·44 enrolled

Efficacy1 trial

Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHF

Withdrawn·—·N/A·NCT02649998

Drug Interactions1 trial

Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

Completed·WWashington State University·Phase 1·NCT03772262·16 enrolled

Acute Myocardial Infarction1 trial

Efficacy of Furosemide Versus Vascular Filling in Patients With Acute Myocardial Infarction

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT02905760·88 enrolled

CAR1 trial

The Effects of Decreasing the Lasix Dose on the Cardiorenal System

Completed·MMayo Clinic·Phase 1/2·NCT00982423·41 enrolled

Acromegaly1 trial

Physiopathology of Sodium Retention in Acromegaly

Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT00531908·12 enrolled

COPD Exacerbation1 trial

The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation

Unknown status·—·Phase 3·NCT05769738·200 enrolled

Metabolism1 trial

A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers

Completed·SSwedish Orphan Biovitrum·Phase 1·NCT03103568·36 enrolled

Obesity1 trial

Effect of Furosemide on Obesity-induced Glomerular Hyperfiltration

Terminated·RRabin Medical Center·N/A·NCT00962286·3 enrolled

Diagnosis1 trial

Influence of Diuresis Timing (F+0 Vs F-15) on 99m Tc DTPA Renography for the Diagnosis of Suspected Obstructive Uropathy

Unknown status·—··NCT04564469·50 enrolled

Peritoneal Dialysis1 trial

Effect of Diuretics on Fluid Status Control and Residual Renal Function in Peritoneal Dialysis Patients

Withdrawn·SSun Yat-sen University·Phase 3·NCT00936923

Fluid Over-load1 trial

Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates

Unknown status·TThe Hospital for Sick Children·Phase 3·NCT00618852·64 enrolled

Colorectal Surgery1 trial

Early Diuresis Following Colorectal Surgery

Completed·MMayo Clinic·Phase 4·NCT02351934·123 enrolled

Infants1 trial

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting·—··NCT03511118·1,600 enrolled

Cardiac Surgical Procedures1 trial

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures

Recruiting·—·N/A·NCT07348510·106 enrolled

Female1 trial

Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers

Withdrawn·UUniversitätsklinikum Hamburg-Eppendorf·Phase 4·NCT01156220

Renal Stones1 trial

Forced Diuresis After Flexible Ureteroscopy for Medium-Sized Renal Stones

Completed·—·N/A·NCT07336485·2,000 enrolled

Unspecified7 trials

Troponin I Release After High Diuretic Doses

Completed·UUniversity of Palermo·Phase 4·NCT01419132·60 enrolled

Specificity of Dyspnoea Relief With Inhaled Furosemide

Completed·OOxford Brookes University·Phase 1·NCT02881866·16 enrolled

Role of Active Deresuscitation After Resuscitation:

Not yet recruiting·UUnity Health Toronto·Phase 2·NCT06326112·120 enrolled

Show 4 more trials

B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading

Completed·—·N/A·NCT01584518·50 enrolled

Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy

Completed·UUniversity of South Florida·Phase 4·NCT02960412·150 enrolled

Bioequivalence Study of Furosemide 40 mg Tablet in 24 Indonesian Healthy Volunteers

Completed·PPT. Kimia Farma (Persero) Tbk·N/A·NCT04982874·24 enrolled

A Two-Part Clinical Study to Evaluate the Effect of Multiple Doses of MK-2828 on Rosuvastatin (Part 1) and Furosemide (Part 2) in Healthy Participants

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT07431866·41 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

FUROSEMIDE

NDA NDA018267

Jan 1, 1982

FUROSEMIDE

NDA NDA018569

Jan 1, 1982

LASIX

NDA NDA016273

Jan 1, 1982

LASIX

NDA NDA017688

Jan 1, 1982

LASIX

NDA NDA016363

Jan 1, 1982

FUROSEMIDE

NDA NDA018487

Jan 1, 1982

FUROSEMIDE

NDA NDA018025

Feb 26, 1982

FUROSEMIDE

NDA NDA018420

May 14, 1982

FUROSEMIDE

NDA NDA018369

May 28, 1982

FUROSEMIDE

NDA NDA018667

Jul 20, 1982

FUROSEMIDE

NDA NDA018670

Jul 27, 1982

FUROSEMIDE

NDA NDA018415

Jul 30, 1982

FUROSEMIDE

NDA NDA018507

Jan 31, 1983

FUROSEMIDE

NDA NDA018419

Jun 28, 1983

FUROSEMIDE

NDA NDA018868

Nov 10, 1983

FUROSEMIDE

NDA NDA018823

Nov 29, 1983

FUROSEMIDE

NDA NDA018790

Nov 30, 1983

FUROSEMIDE

NDA NDA018413

Nov 30, 1983

FUROSEMIDE

NDA NDA018579

Feb 28, 1984

FUROSEMIDE

NDA NDA018753

May 22, 1984

FUROSEMIDE

NDA NDA018902

Jun 26, 1984

FUROSEMIDE

NDA NDA018370

Jul 30, 1984

FUROSEMIDE

NDA NDA018750

Aug 13, 1984

FUROSEMIDE

NDA NDA019036

Oct 7, 2022

FUROSCIX

NDA NDA209988

Oct 7, 2025

LASIX ONYU

NDA NDA217294

Sources

References

[1]
ClinicalTrials.gov — 166 trial records for Furosemide. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Lasix drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Furosemide compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Furosemide. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA217294). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Lasix. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Validus Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium-(potassium)-Chloride Cotransporter 2 Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: VValidus Pharmaceuticals

Patent Landscape[6]

Patent Cliff

Apr 3, 2034

Earliest patent expiration — generic entry possible after this date

Patent #Expires

11433044Apr 3, 2034

9884039Apr 3, 2034

12370168Apr 3, 2034

10272064Apr 3, 2034

Lasix

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2027

Trials by Indication[1]

Heart Failure31 trials

Acute Kidney Injury7 trials

Hypertension7 trials

Interaction6 trials

Congestive Heart Failure4 trials

Dyspnea4 trials

Chronic Kidney Disease4 trials

Treatment3 trials

Metformin3 trials

AIN3 trials

Critically Ill Patients3 trials

Preeclampsia2 trials

Clinical Pharmacology2 trials

Nephrotic Syndrome2 trials

Kidney2 trials

Cutaneous Warts2 trials

Blood Pressure2 trials

Cirrhosis2 trials

Tics2 trials

Function2 trials

MPA2 trials

Recovery1 trial

Nasal polyposis1 trial

Ultrasound1 trial

Efficacy and Safety1 trial

Blood Transfusion1 trial

Type 2 Diabetes1 trial

Bronchiolitis1 trial

Hypertensive1 trial

Drug1 trial

Necrosis1 trial

Dialysis Patients1 trial

Intensive Care1 trial

Physical Activity1 trial

Myocardial fibrosis1 trial

Congenital Heart Disease1 trial

TED1 trial

Right Ventricular Dysfunction1 trial

Chronic Renal Failure1 trial

Leukemia1 trial

Metastatic Melanoma1 trial

Intensive Care Unit1 trial

Semaglutide1 trial

Renal insufficiency1 trial

Prostate Cancer1 trial

Complication1 trial

Critical Ill Patients1 trial

Hemodynamic1 trial

Acute Myeloid Leukemia1 trial

Kidney Stones1 trial

Ascites1 trial

Pulmonary Edema1 trial

Actinic Keratosis1 trial

Infusion1 trial

Imaging1 trial

SGLT-2 Inhibitor1 trial

Oral1 trial

Outcome1 trial

Hemodialysis1 trial

Pediatric Patients1 trial

Renal Replacement Therapy1 trial

Kidney Transplant1 trial

Breast Cancer1 trial

Immunity1 trial

Orthostatic Intolerance1 trial

TTN1 trial

Bronchopulmonary Dysplasia1 trial

Age1 trial

Fasting Conditions1 trial

Efficacy1 trial

Drug Interactions1 trial

Acute Myocardial Infarction1 trial