Marcaine

Phase 1Small molecule

UUniversity of Chicago

Marcaine is one of 61 small molecule programs targeting Total Knee Arthroplasty. It is currently in Phase 1.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Total Knee ArthroplastyActive, not recruiting

Femur FractureActive, not recruiting

Nerve BlockNot yet recruiting

Total Knee ArthroplastyPreclinical

Active, not recruiting

Femur FracturePreclinical

Active, not recruiting

Nerve BlockPhase 1

Not yet recruiting

Competition

Competitive Landscape

67 competitors in Total Knee Arthroplasty

#DrugCompanyPhaseTrials

Naropin

FFresenius Kabi USA, LLC

Approved

26 2

Cyklokapron

JJ Molner

Approved

25 3

Marcaine

IInnocoll

Approved

18 4

Decadron

AAspen Global Incorporated

Approved

17 5

Medrol

Pfizer

Approved

4 6

Carbocaine

Pfizer

Approved

3 7

Journavx

Vertex Pharmaceuticals

Approved

2 8

Lexapro

AbbVie

Approved

1 9

MS Contin

HHikma Pharmaceuticals LLC

Approved

7 10

Adrenaline

SSamson Clinical Operations Pty Ltd

Approved

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Inguinal hernia2 trials

Ilioinguinal Block in Laparoscopic Inguinal Hernia Repair

Withdrawn·RRanders Regional Hospital·Phase 2·NCT01969006

Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia.

Completed·AAstes·Phase 4·NCT02049255·50 enrolled

Post Operative Pain2 trials

The Efficacy of Peritubal Analgesic Infiltration in Postoperative Pain Following Percutaneous Nephrolithotomy

Completed·SSaddam Al Demour·N/A·NCT04160936·50 enrolled

Early Post-Operative Pain Control Following Wrist Operations

Unknown status·UUniversity of Tennessee·N/A·NCT02052180·70 enrolled

Femur Fracture1 trial

Efficacy Study of Femoral Nerve Block in Children With a Femur Fracture

Terminated·WWashington University School of Medicine·N/A·NCT01294098·2 enrolled

Migraine1 trial

Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine

Completed·TTian Medical Inc.·Phase 4·NCT01709708·41 enrolled

Total Knee Arthroplasty1 trial

Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)

Unknown status·RRothman Institute Orthopaedics·N/A·NCT02060591

15 more indications

Local Anesthetic1 trial

Comparison of Local Anesthetic Infusion Pump Versus DepoFoam Bupivacaine for Pain Management

Withdrawn·HHenry Ford Health System·Phase 4·NCT02542956

General Anesthesia1 trial

Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy

Completed·UUniversity of Chicago·N/A·NCT02205801·36 enrolled

Hernia1 trial

Pain Relief After Hiatal Hernia Repair Surgery

Unknown status·NNorton Thoracic Institute·Phase 4·NCT04936711·90 enrolled

Epidural Block1 trial

Is There a Relation Between Unilateral Epidural Block and Repeated Epidural Anesthesia?

Completed·—·Phase 4·NCT03806673·140 enrolled

Pain1 trial

Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel

Withdrawn·UUniversity of Louisville·Phase 4·NCT02571283

Tics1 trial

Anesthetics in Rhytidoplasty - A Comparison Study

Completed·MMercy Facial Plastic Surgery Center·N/A·NCT02410460·30 enrolled

Knee Replacement Surgery1 trial

Analgesia After Total Knee Replacement Surgery

Completed·SSt. Antonius Hospital·N/A·NCT01489631·81 enrolled

Laparoscopic1 trial

Pain Relieving Efficacy of TAP Block in Patients After Laparoscopic Gastric Bypass.

Completed·FFunch-Jensen, Peter, M.D., D.M.Sc.·Phase 4·NCT01308554·80 enrolled

Effectiveness1 trial

Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections

Withdrawn·MMichael Khazzam·Phase 4·NCT04895280

Anterior Cruciate Ligament Reconstruction1 trial

Pain Outcomes After Anterior Cruciate Ligament Reconstruction With Posterior Capsular Marcaine Injection

Terminated·—·N/A·NCT02826551·23 enrolled

Arthroscopic Shoulder Surgery1 trial

Intra-Operative Corticosteroid Injection During Arthroscopic Shoulder Surgery

Terminated·PPeter Chang·Phase 4·NCT02867904·12 enrolled

Nerve Block1 trial

Dorsal Nerve Block and Caudal Block in Hypospedius Repair in Children

Not yet recruiting·—·Phase 1·NCT06500286·103 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Postoperative Pain Control1 trial

Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures

Completed·LLoma Linda University·Phase 4·NCT02805504·136 enrolled

Obesity, Morbid1 trial

Multimodal Analgesia Effect on Post Surgical Patient

Completed·UUniversity of California, Davis·Approved·NCT04240626·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 22 trial records for Marcaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Marcaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Marcaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Chicago company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 1[1]
Company: UUniversity of Chicago

Marcaine

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Inguinal hernia2 trials

Post Operative Pain2 trials

Femur Fracture1 trial

Migraine1 trial

Total Knee Arthroplasty1 trial

Local Anesthetic1 trial

General Anesthesia1 trial

Hernia1 trial

Epidural Block1 trial

Pain1 trial

Tics1 trial

Knee Replacement Surgery1 trial

Laparoscopic1 trial

Effectiveness1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Arthroscopic Shoulder Surgery1 trial

Nerve Block1 trial

Perioperative Pain Control1 trial

Postoperative Pain Control1 trial

Obesity, Morbid1 trial

References

Drug Info

Quick Facts

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