Chirocaine
(Levobupivacaine)ApprovedSmall molecule
Levobupivacaine is a local anesthetic used to numb specific areas of the body during surgery, dental procedures, or pain management treatments so patients don't feel pain in that region.[2] Chirocaine is currently approved and in use across 20 indications[4].[1]
Chirocaine is one of 316 small molecule programs targeting Cleft Palate. It is currently in Approved.
20
Indications
100
Total Trials
6
Active Trials
315
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 18 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Chirocaine
PPurdue Pharma LP
Approved
DATROWAY
Daiichi SankyoPreclinical
Megace
Bristol-Myers SquibbPreclinical
Cymbalta
Alnylam PharmaceuticalsPreclinical
MS Contin
Merck & Co.Preclinical
Zolymbus
AbbViePreclinical
Blenoxane
Bristol-Myers SquibbPreclinical
Lupron
EEastern Cooperative Oncology Group
Preclinical
Zinecard
CChildren's Oncology Group
Preclinical
Effexor
WWyeth-Lederle Vaccines
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Bupivacaine15 trials
Interest in Clonidine in Association With Levobupivacaine Performing a Pudendal Block in Proctological Surgery.
Unknown status·—·Phase 4·NCT04530903·30 enrolled
TAP Block With Two Different Doses of Levobupivacaine
Unknown status·—·Phase 4·NCT02567487·50 enrolled
Show 12 more trials
Dexmeditomedine as an Adjuvant to Levobupivacaine in Transversus Thoracis Plane Block on the Management of Post-sternotomy Pain in Open-heart Surgeries
Not yet recruiting·—·N/A·NCT06410404·60 enrolled
Effect of Fentanyl With Topical Levobupivacaine With Nasal Packing in Endoscopic Nasal Surgery
Unknown status·—·Phase 2·NCT04410588·75 enrolled
Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section
Completed·—·Phase 2·NCT02430090·45 enrolled
Comparison of 0.375% Ropivacaine and 0.25% Levobupivacaine for Infraclavicular Brachial Plexus Block
Completed·—·Phase 4·NCT03679897·46 enrolled
Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
Completed·—·Phase 4·NCT02201784·60 enrolled
Caudal Block With Tramadol and Levobupivacaine or Bupivacaine
Completed·—··NCT01974843·68 enrolled
Analgesic Effect of Levobupivacaine in Breast Augmentation
Suspended·—·Phase 4·NCT02465008·66 enrolled
Spinal Anesthesia4 trials
Labor Analgesia4 trials
Dexmedetomidine4 trials
Dexmedetomidine Versus Fentanyl Added to Levobupivacaine for Transversus Abdominis Plane (TAP) Block
Completed·—·Phase 1/2·NCT03778671·90 enrolled
Show 1 more trial
Dexmedetomidine Versus Clonidine in TAP Block
Completed·—·Phase 2/3·NCT03155646·90 enrolled
Total Knee Arthroplasty3 trials
Single-shot Adductor Canal Block With Levobupivacaine and Dexmedetomidine in Total Knee Arthroplasty
Completed·—·Phase 2/3·NCT04968392·60 enrolled
Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine
Unknown status·—·Phase 4·NCT01158586·60 enrolled
57 more indications
Quadratus Lumborum Block2 trials
Efficacy and Safety of Adding Dexmedetomidine to Levobupivacaine in Rectus Sheath Block Compared to Quadratus Lumborum Block in Patients Undergoing Lower Abdominal Cancer Surgery: a Randomized Clinical Trial
Not yet recruiting·—·Phase 4·NCT06695468·122 enrolled
Serratus-intercostal Plane Block Versus Quadratus Lumborum Block in Nephrectomy: Randomized Study
Completed·—··NCT04431388·126 enrolled
Dexamethasone2 trials
Tramadol Versus Dexamethasone as Adjuvant to Levobupivacaine Supraclavicular Block
Unknown status·—·Phase 4·NCT04551833·60 enrolled
Total Hip Arthroplasty2 trials
Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty
Recruiting·—·Phase 2·NCT06577155·60 enrolled
General Anesthesia2 trials
Hemodynamic2 trials
Inguinal hernia2 trials
Comparison of Postoperative Analgesic Efficacy of Caudal Block Versus Spinal Block With Levobupivacaine for Inguinal Hernia in Children
Completed·—·N/A·NCT05117281·60 enrolled
Dexmedetomidine to Levobupivacaine for Transversus Abdominis Plane Block in Elderly Patients Undergoing Inguinal Hernia Repair Surgery
Completed·—·Phase 2/3·NCT04971759·90 enrolled
Nerve Block2 trials
Pectoral Nerve Block2 trials
Abdominal Cancer Surgery2 trials
Ultrasound2 trials
Ultrasound-Guided Versus Conventional Injection for Caudal Block
Completed·—·N/A·NCT03337191·134 enrolled
Cesarean Section2 trials
Cholecystectomy2 trials
Levobupivacaine During Cholecystectomy
Completed·—·Phase 4·NCT00836316·40 enrolled
Caesarean Section2 trials
Spinal Anesthesia in Caesarean Section
Unknown status·—··NCT03743870·250 enrolled
Acute Postoperative Pain1 trial
Prospective1 trial
Total Knee Replacement1 trial
The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement
Unknown status·—·Phase 4·NCT01312415·42 enrolled
Aesthetic1 trial
Local Anaesthetic and Steroid in the Ureter
Unknown status·TThe Adelaide and Meath Hospital, incorporating The National Children's Hospital·N/A·NCT03296189·150 enrolled
Inflammatory Response1 trial
Hysterectomy1 trial
Infiltration1 trial
Femoral Nerve Block1 trial
Hip Arthroscopy; Femoral Nerve Block or Fascia Iliaca Block
Unknown status·—·Phase 4·NCT05010499·30 enrolled
Interscalene Block1 trial
Postoperative Pain Control1 trial
Postoperative Pain Control Using ON-Q Painbuster Pump
Completed·—·Phase 3·NCT01184794·60 enrolled
Cesarean Delivery1 trial
Laparoscopic Sleeve Gastrectomy1 trial
Surgery1 trial
Staphylococcus Aureus1 trial
Investigation of Antibacterial Effect of Levobupivacaine on Staphylococcus Aureus
Completed·—·N/A·NCT07285759·40 enrolled
ACL1 trial
The Simultaneous Use of Supraclavicular and Distal Blocks
Completed·—·Phase 4·NCT01989312·75 enrolled
Cleft Palate1 trial
Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery
Completed·—·Phase 2/3·NCT02923869·60 enrolled
Minimal Invasive Cardiac Surgery1 trial
Delirium1 trial
Delirium in Elderly Patients With Trauma of the Hip
Terminated·—·Phase 4·NCT02689024·239 enrolled
Osteoarthritis1 trial
Treatment1 trial
Quadratus Lumborum Type 2 as Chronic Hip Pain Treatment
Completed·—··NCT04438265·200 enrolled
Arthroscopy1 trial
PRCT of FICB vs LAI for Hip Arthroscopy
Completed·—·N/A·NCT02702661·46 enrolled
Sternotomy1 trial
Advantage of Tramadol in Local Analgesia Post-Sternotomy
Completed·—·Phase 4·NCT02851394·160 enrolled
Pediatric Patients1 trial
Hip Arthroplasty1 trial
Postoperative Analgesia1 trial
Hip Fracture1 trial
Comparative Study Between Levobupivacaine and Ropivacaine in the Hip Fractures of the Elderly
Completed·FFundación Instituto de Estudios de Ciencias de la Salud de Castilla y León·Phase 4·NCT04773301·114 enrolled
Pregnancy1 trial
Peripheral Nerve Block1 trial
Ultrasound Guided Distal Peripheral Nerve Blocks and Postoperative Pain.
Completed·FFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau·Phase 4·NCT01597479·52 enrolled
Intrathecal Anesthesia1 trial
Cancer1 trial
EUS-guided CGN for Inoperable Cancer
Terminated·—·Phase 2/3·NCT02356640·3 enrolled
Superficial Cervical Plexus Block1 trial
Stellate Ganglion Block1 trial
Randomized Controlled Trial1 trial
Total Hip Replacement1 trial
The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement
Unknown status·—·Phase 4·NCT01312077·50 enrolled
Breast Cancer1 trial
Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery
Completed·—·Phase 2·NCT04275661·60 enrolled
Tonsillectomy1 trial
Regulatory
FDA Approval Timeline[5]
Aug 5, 1999
CHIROCAINE
NDA NDA020997
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Chirocaine drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Levobupivacaine. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Sodium Channel Protein Type IV Alpha Subunit Blocker[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- PPurdue Pharma LP