Circadin

(Melatonin)

ApprovedSmall molecule

Melatonin is used to help regulate sleep-wake cycles and treat insomnia, helping people fall asleep more easily and improving sleep quality.[2] Circadin is currently approved and in use across 130 indications[4].[1]

Circadin is one of 1975 small molecule programs targeting Insulin resistance. It is currently in Approved.

130

Indications

280

Total Trials

Active Trials

1,974

Competitors

Pipeline

Status by Indication[4][1]

Indication

Insulin ResistanceActive, not recruiting

Total Joint ArthroplastyActive, not recruiting

CalcificationActive, not recruiting

CachexiaActive, not recruiting

EnuresisActive, not recruiting

Metabolic SyndromeActive, not recruiting

DyspepsiaActive, not recruiting

Pineal Body NeoplasmActive, not recruiting

Lennox-Gastaut SyndromeActive, not recruiting

Low Back PainActive, not recruiting

Insulin ResistanceApproved

Active, not recruiting

Total Joint ArthroplastyPhase 1

Active, not recruiting

CalcificationApproved

Active, not recruiting

CachexiaPreclinical

Active, not recruiting

EnuresisPhase 2

Active, not recruiting

Metabolic SyndromePhase 2

Active, not recruiting

DyspepsiaPreclinical

Active, not recruiting

Pineal Body NeoplasmPhase 1

Active, not recruiting

Lennox-Gastaut SyndromeApproved

Active, not recruiting

Low Back PainPhase 3

Active, not recruiting

Showing 10 of 125 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Circadin

NNeurim Pharmaceuticals Ltd.

Approved

11 2

Avastin

Prolia

14 4

Blenoxane

Bristol-Myers Squibb

Preclinical

1 5

Voltaren

Novartis

Preclinical

1 6

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 7

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 8

Zinecard

CChildren's Oncology Group

Preclinical

2 9

Tricor

JJagotec

Preclinical

1 10

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Total Hip Arthroplasty

NCT06768580

Phase 2Recruiting

Delirium

NCT05713877

N/ANot yet recruiting

Alzheimer's Disease

NCT06756828

Q1 2027

Phase 3Recruiting

Agitation

NCT05541276

Phase 2/3Recruiting

Combination Therapy

NCT05474846

Q3 2027

N/ARecruiting

Agitation

NCT07345715

Clinical

Trials by Indication[1]

Melatonin19 trials

Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 2·NCT02195271·50 enrolled

Effects of Melatonin in PCOS Women

Unknown status·—·N/A·NCT02663570·40 enrolled

Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.

Terminated·—·Phase 2·NCT02631148·12 enrolled

Show 16 more trials

The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease

Withdrawn·MMansoura University·Phase 3·NCT00915616

Melatonin in Healthy Volunteers

Completed·UUniversity of Aberdeen·Phase 1·NCT01724424·20 enrolled

SThe Effects of Melatonin on GERD Symptoms

Unknown status·RRabin Medical Center·Phase 1/2·NCT00564590·150 enrolled

Melatonin Use for Sleep Problems in Alcohol Dependent Patients

Completed·CCentre for Addiction and Mental Health·Phase 2·NCT03043443·60 enrolled

Does Melatonin Restore Sleep Architecture in Autistic Children

Completed·HHospices Civils de Lyon·Phase 2·NCT01993251·26 enrolled

Melatonin Receptor Agonist and Peripheral Biological Markers

Completed·NNational Science and Technology Council, Taiwan··NCT03432091·40 enrolled

Melatonin Studies of Totally Blind Children

Terminated·OOregon Health and Science University·N/A·NCT00795236·13 enrolled

Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients

Unknown status·MMohammad Sadegh Bagheri Baghdasht·N/A·NCT04409522·55 enrolled

Pharmacokinetics of Melatonin Niosomes Oral Gel in Healthy Volunteers

Unknown status·KKhon Kaen University·Phase 1/2·NCT02845778·15 enrolled

The Sun Protective Effect of Melatonin

Completed·HHerlev Hospital·Phase 1·NCT01873430·22 enrolled

Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

Completed·—·Phase 1·NCT04005222·28 enrolled

Effect of Melatonin on Cardiometabolic Risk- FULL

Unknown status·—·Phase 3·NCT02681887·120 enrolled

The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers.

Completed·—·N/A·NCT02107079·10 enrolled

Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

Completed·HHerlev Hospital·Phase 4·NCT01087359·12 enrolled

Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study

Completed·IImperial College London·Phase 2·NCT00649961·18 enrolled

Melatonin Effects on Luteinizing Hormone

Terminated·SScripps Health·Phase 1/2·NCT00288262·20 enrolled

Delirium11 trials

Melatonin for Treatment of Delirium in Critically Ill Adult Patients

Recruiting·CCiusss de L'Est de l'Île de Montréal·Phase 2·NCT05713877·30 enrolled

Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium

Completed·—·Phase 1/2·NCT04189666·180 enrolled

Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol

Withdrawn·LLoyola University·Phase 4·NCT02903901

Show 8 more trials

Prevention of Delirium in Inpatients Utilizing Melatonin

Terminated·YYale University·Phase 3·NCT02654314·277 enrolled

Melatonin for Prevention of Delirium in Critically Ill Patients

Unknown status·MMount Sinai Hospital, Canada·Phase 2·NCT02615340·69 enrolled

Melatonin for Post Operative Delirium Prevention in Elderly Patients

Completed·MMenoufia University·Phase 2·NCT05640934·100 enrolled

The Efficacy of Oral Melatonin in Preventing Postoperative Delirium for Patients Undergoing Orthopedic Surgery Under General Anesthesia

Completed·UUniversity of Baghdad·N/A·NCT05236907·36 enrolled

Melatonin for Prevention of Post Stroke Delirium

Unknown status·UUniversity Hospital Tuebingen·Phase 2/3·NCT04122599·2,000 enrolled

Efficacy of Melatonin in Decreasing the Incidence of Delirium in End of Life Patients

Completed·FFraser Health·Phase 3·NCT02536417·19 enrolled

Melatonin for Delirium Prophylaxis

Withdrawn·UUniversity of British Columbia·Phase 4·NCT02282241

Prevention of Delirium in Intensive Care by Melatonin

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 2/3·NCT03524937·355 enrolled

Breast Cancer9 trials

Melatonin Postoperative Sleep Study in Breast Cancer Patients

Terminated·MM.D. Anderson Cancer Center·Phase 1·NCT00506064·4 enrolled

Melatonin as Adjuvant Therapy in Breast Cancer Patients

Unknown status·KKhon Kaen University·Phase 2/3·NCT01557478·166 enrolled

Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer

Unknown status·NN.N. Petrov National Medical Research Center of Oncology·Phase 2·NCT02506790·96 enrolled

Show 6 more trials

Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer

Completed·JJuravinski Cancer Center·Phase 2·NCT01965522·100 enrolled

Melatonin in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Not yet recruiting·MMansoura University·Phase 1/2·NCT07067307·80 enrolled

Neoadjuvant FDC With Melatonin or Metformin for Locally Advanced Breast Cancer.

Unknown status·NN.N. Petrov National Medical Research Center of Oncology·Phase 2·NCT02506777·96 enrolled

Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer

Completed·DDennis Bregner Zetner·Phase 2·NCT03716583·48 enrolled

Immediate or Delayed Naturopathic Medicine in Combination With Neo-Adjuvant Chemotherapy for Breast Cancer

Terminated·MMidwestern Regional Medical Center·Phase 1/2·NCT02486796·5 enrolled

The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients

Terminated·MMelissa Voigt Hansen·Phase 2/3·NCT01355523·54 enrolled

Treatment9 trials

Blind Elderly Melatonin Treatment Study

Terminated·OOregon Health and Science University·N/A·NCT00692094·12 enrolled

Melatonin for the Treatment of DEE-SWAS

Not yet recruiting·HHugo W. Moser Research Institute at Kennedy Krieger, Inc.·Phase 2·NCT07221968·3 enrolled

Blind Child Melatonin Treatment Study

Terminated·OOregon Health and Science University·N/A·NCT00691444·10 enrolled

Show 6 more trials

Acute Metabolic Effects of Melatonin Treatment

Completed·UUniversity of Aarhus·Phase 1/2·NCT03204877·36 enrolled

ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments

Completed·—·Phase 2·NCT06429059·50 enrolled

Young Blind Child Melatonin Treatment Study

Terminated·OOregon Health and Science University·N/A·NCT00688935·9 enrolled

Metabolic Effects of Melatonin Treatment

Completed·UUniversity of Aarhus·Phase 1·NCT03859934·17 enrolled

Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy

Unknown status·UUniversitat Internacional de Catalunya·Phase 2/3·NCT05536596·220 enrolled

The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase Disorder

Completed·UUniversity of Michigan·Phase 3·NCT03715465·44 enrolled

Migraine5 trials

Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine

Completed·HHospital Israelita Albert Einstein·Phase 3·NCT01357031·192 enrolled

Melatonin for Migraine Prevention

Completed·NNordlandssykehuset HF·Phase 2·NCT00849511·48 enrolled

CHOCOlate MeLatonin for AdolescenT MigrainE

Completed·AAmy Gelfand·Phase 2·NCT03597529·84 enrolled

Show 2 more trials

Bringing Relief to Adolescents Naturally Using Melatonin for Migraine

Completed·AAmy Gelfand·Phase 2·NCT02344316·31 enrolled

Melatonin for Adolescent Migraine Prevention Study

Terminated·AAmy Gelfand·Phase 2·NCT03150797·72 enrolled

110 more indications

Agitation5 trials

Nebulized Dexmedetomidine VS ODF Melatonin for Peri Operative Anxiety and Emergence Agitation in Pediatric Day Surgery

Unknown status·Nnada moahmed aboelrouse·N/A·NCT05766436·50 enrolled

Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric

Enrolling by invitation·—·N/A·NCT07375342·120 enrolled

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children

Recruiting·RRigshospitalet, Denmark·Phase 3·NCT05541276·400 enrolled

Show 2 more trials

Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine

Completed·—·Phase 4·NCT04908605·165 enrolled

Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy

Recruiting·TTanta University·N/A·NCT07345715·96 enrolled

Insomnia5 trials

Exogenous Melatonin in Postmenopausal Women with Insomnia

Terminated·—·N/A·NCT05440734·6 enrolled

Efficacy and Safety of Slenyto for Insomnia in Children With ASD

Withdrawn·NNeurim Pharmaceuticals Ltd.·Phase 3·NCT04233502

Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary Insomnia

Recruiting·—·N/A·NCT06996171·60 enrolled

Show 2 more trials

A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Pharmacokinetic Study

Recruiting·WWoolcock Institute of Medical Research·Phase 1·NCT06801379·5 enrolled

Effects of Melatonin on Insomnia Symptoms in Older Adults

Completed·NNalaka Gooneratne·Phase 2·NCT00230737·27 enrolled

COVID-194 trials

Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19

Completed·UUnidad Temporal COVID-19 en Centro Citibanamex·N/A·NCT04570254·110 enrolled

Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19

Terminated·SState University of New York at Buffalo·Phase 2·NCT04474483·8 enrolled

Selective Estrogen Modulation and Melatonin in Early COVID-19

Withdrawn·—·Phase 2·NCT04531748

Show 1 more trial

Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19

Withdrawn·SState University of New York at Buffalo·Phase 2·NCT04784754

Sedation3 trials

Melatonin vs Pregabalin for Anxiolysis and Sedation

Completed·MMenoufia University·Phase 4·NCT05221151·78 enrolled

Sedation and Nursing Management in EEG Recording in Children

Completed·SSuleyman Demirel University·N/A·NCT05492812·180 enrolled

A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI

Completed·—·N/A·NCT06606899·60 enrolled

Multiple Sclerosis3 trials

Effect of Melatonin on Multiple Sclerosis Related Fatigue

Completed·IIsfahan University of Medical Sciences·Phase 2·NCT01718678·44 enrolled

The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects

Completed·TTehran University of Medical Sciences·N/A·NCT02463318·34 enrolled

Melatonin in Patients With Multiple Sclerosis (MS).

Completed·PProvidence Health & Services·Phase 1·NCT03498131·30 enrolled

Alzheimer's Disease2 trials

Study of Melatonin: Sleep Problems in Alzheimer's Disease

Completed·NNational Institute on Aging (NIA)·Phase 3·NCT00000171

Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum

Not yet recruiting·SSaint Vincent's Hospital, Korea·N/A·NCT06756828·40 enrolled

Fatigue2 trials

Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy

Terminated·VVirginia Commonwealth University·Phase 3·NCT02332928·80 enrolled

Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer

Completed·—·Phase 2/3·NCT00925899·72 enrolled

Bipolar Disorder2 trials

Melatonin Versus Placebo for Bipolar Disorder

Not yet recruiting·LLars Vedel Kessing·Phase 2·NCT07472075·200 enrolled

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

Recruiting·LLeslie Swanson·Phase 2·NCT06226025·50 enrolled

Blood Pressure2 trials

Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study

Completed·EEmory University·Phase 2·NCT01114373·40 enrolled

Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study

Completed·EEmory University·Phase 2·NCT01114360·37 enrolled

Parkinson's Disease2 trials

Melatonin for Nocturia in Parkinson's Disease

Unknown status·UUniversity College, London·Phase 2·NCT02359448·20 enrolled

Melatonin on Clock Genes in Parkinson's Disease

Withdrawn·IInstituto Mexicano del Seguro Social·Phase 2/3·NCT04287543

Postoperative Analgesia2 trials

Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia

Completed·—·Phase 4·NCT02639741·55 enrolled

Effect of Oral Melatonin on Postoperative Analgesia After Thoracotomy in Infants

Completed·—·Phase 1·NCT05141344·50 enrolled

Post Operative Pain2 trials

Effect of Melatonin on Postoperative Pain After Simple Nephrectomy

Completed·—·Phase 1·NCT06872944·40 enrolled

Melatonin on Post Operative Pain After CS

Recruiting·—·N/A·NCT07380568·60 enrolled

Sleep Disorder2 trials

Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders

Unknown status·NNational Heart, Lung, and Blood Institute (NHLBI)·N/A·NCT00387179·48 enrolled

Melatonin for Circadian Sleep Disorders in the Blind

Terminated·OOregon Health and Science University·N/A·NCT00911053·59 enrolled

Diabetes Mellitus2 trials

The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1

Unknown status·SSheba Medical Center·Phase 1·NCT02644590·30 enrolled

Melatonin's Effects on Treatment Of Diabetes Mellitus

Unknown status·SShiraz University of Medical Sciences·Phase 1·NCT02691897·60 enrolled

Pulmonary Hypertension2 trials

Melatonin for Pulmonary Hypertension in Full Term Neonates

Completed·—·Phase 3·NCT06685679·40 enrolled

Melatonin Effects on the Left Ventricular Function in Neonates With Persistent Pulmonary Hypertension

Completed·TTanta University·N/A·NCT07090720·80 enrolled

Randomized2 trials

Effect of Melatonin on Schizophrenic Symptoms: a Randomized Placebo-Controlled Trial

Active, not recruiting·LLahore General Hospital·N/A·NCT06838104·76 enrolled

The Basel BOMP-AID Randomized Trial

Recruiting·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT03438526·190 enrolled

Encephalopathy2 trials

EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES

Active, not recruiting·UUniversity of Child Health Sciences and Children's Hospital, Lahore·Phase 2·NCT07305350·110 enrolled

Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy

Withdrawn·SSt. Louis University·Phase 1·NCT01904786

Epilepsy2 trials

Pilot Study of Melatonin and Epilepsy

Completed·—·Phase 2·NCT00965575·11 enrolled

Getting SMART for Pediatric Epilepsy

Completed·NNational Taiwan University Hospital·Phase 2/3·NCT05439876·147 enrolled

Brain Injury2 trials

Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies

Completed·MMonash University·Phase 4·NCT01695070·16 enrolled

Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin

Completed·OOregon Health and Science University·Phase 2·NCT04932096·21 enrolled

Circadian Rhythm2 trials

HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness

Recruiting·FFirst Affiliated Hospital of Zhejiang University·N/A·NCT05285124·90 enrolled

Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms

Completed·—·N/A·NCT03826563·21 enrolled

Hypertension2 trials

Melatonin Supplements for Improving Sleep in Individuals With Hypertension

Completed·—·Phase 2·NCT00238108·16 enrolled

Study MIPAE - Melatonin and Essential Arterial Hypertension

Unknown status·AAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia·Phase 2·NCT05257291·23 enrolled

Ovarian Reserve2 trials

of Myo-inositol, Melatonin and Co-enzyme q10 on Ovarian Reserve

Not yet recruiting·—·Phase 3·NCT06405204·200 enrolled

Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve

Active, not recruiting·—·Phase 2·NCT07318974·64 enrolled

Attention Deficit Hyperactivity Disorder2 trials

Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep Difficulties

Unknown status·—·Phase 4·NCT01393574·46 enrolled

Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)

Completed·—·Phase 1/2·NCT00867451·8 enrolled

Laparoscopic Cholecystectomy2 trials

Melatonin in Obese Patients in Laparoscopic Cholecystectomy

Not yet recruiting·—·N/A·NCT06355687·60 enrolled

Melatonin Treatment After Laparoscopic Cholecystectomy

Completed·UUniversity Hospital, Gentofte, Copenhagen·Phase 2/3·NCT00113906·200 enrolled

Analgesic2 trials

Anxiolytic and Analgesic Effects of Melatonin

Completed·HHerlev Hospital·Phase 3·NCT02386319·36 enrolled

The Analgesic Effects of Melatonin

Completed·LLars Peter Holst Andersen·Phase 2/3·NCT01923974·36 enrolled

Diabetic Retinopathy2 trials

Sleep, Diabetic Retinopathy and Melatonin

Recruiting·UUniversity of Illinois at Chicago·Phase 2·NCT04547439·42 enrolled

Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm

Completed·GGlostrup University Hospital, Copenhagen·Phase 3·NCT03478306·31 enrolled

Asphyxia1 trial

Melatonin for Neuroprotection Following Perinatal Asphyxia

Completed·TTanta University·Phase 1/2·NCT02071160·45 enrolled

Ulcerative Colitis1 trial

Melatonin and Ulcerative Colitis: A Pilot Clinical Trial

Terminated·EEmory University·Phase 2·NCT00790478·3 enrolled

Oncology Patients1 trial

Phase I Dose Finding Study for Melatonin in Pediatric Oncology Patients With Relapsed Solid Tumors

Completed·CC17 Council·Phase 1·NCT01858155·9 enrolled

Intensive Care1 trial

Melatonin Use in the Intensive Care Elderly Population

Unknown status·MMICE Trial Group·Phase 4·NCT03013790·600 enrolled

Stroke1 trial

Safety Study of Melatonin in Stroke Patients

Unknown status·WWolfson Medical Center·Phase 4·NCT01863277·140 enrolled

Double-blind1 trial

MELATOX: Evaluation of Percutaneous Dissolvement of Melatonin When Used as Sunscreen; a Randomized, Placebo Controlled, Double-blind Crossover Study on Healthy Volunteers.

Completed·ZZealand University Hospital·Phase 1·NCT02224937·10 enrolled

Pneumonia1 trial

The Role of Melatonin as an Adjuvant Therapy in Childhood Pneumonia

Recruiting·MMian Muhammad Hassan Ahmed·Phase 1/2·NCT06949904·60 enrolled

Hemodynamic Response1 trial

Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients

Not yet recruiting·TTanta University·Phase 2/3·NCT06935292·70 enrolled

Uveal Melanoma1 trial

Adjuvant Melatonin for Uveal Melanoma

Recruiting·GGustav Stalhammar·Phase 3·NCT05502900·100 enrolled

Postoperative Recovery1 trial

The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery

Completed·SSheba Medical Center·Phase 4·NCT02424071·60 enrolled

Cognitive impairment1 trial

The Effect of Melatonin on Cognitive Function in Patients Diagnosed With Mild Cognitive Impairment

Unknown status·—·Phase 2·NCT00544791·50 enrolled

Acute Myocardial Infarction1 trial

The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty

Terminated·AAlberto Domínguez Rodríguez·Phase 2·NCT00640094·272 enrolled

Major Surgery1 trial

Melatonin and Cardiac Outcome After Major Surgery

Completed·UUniversity Hospital, Gentofte, Copenhagen·Phase 2/3·NCT00315926·52 enrolled

Liver Transplant1 trial

Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.

Unknown status·—·Phase 3·NCT01860716·60 enrolled

Osteopenia1 trial

Treatment of Osteopenia With Melatonin

Completed·UUniversity of Aarhus·N/A·NCT01690000·81 enrolled

Cachexia1 trial

Multimodal Treatment Strategy for Cancer Cachexia

Terminated·MM.D. Anderson Cancer Center·N/A·NCT00625742·15 enrolled

Dyspepsia1 trial

Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia

Completed·MMedical University of Lodz·N/A·NCT04352062·152 enrolled

Peritoneal Dialysis1 trial

The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients

Completed·MMeander Medical Center·Phase 3·NCT00404456·40 enrolled

Metastatic Cancer1 trial

Impact of a Melatonin Supplementation on the Quality of Life in Elderly Metastatic Cancer Patients

Terminated·CCentre Jean Perrin·Phase 3·NCT02454855·123 enrolled

Oxygen Consumption1 trial

Effects of Melatonin and Oxygen Consumption and Choroidal Blood Flow

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT00675181·16 enrolled

Atrial Fibrillation1 trial

Cardiac Surgery and the Risk of Atrial Fibrillation: an Intervention Trial Evaluating Melatonin

Withdrawn·JJohns Hopkins University·Phase 2·NCT02099331

Sepsis1 trial

Dose Assessment of Melatonin in Sepsis Trial

Withdrawn·UUniversity of Aberdeen·Phase 1/2·NCT02319265

Chronic Kidney Disease1 trial

Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders

Unknown status·SSoutheast Renal Research Institute·Phase 2/3·NCT01922999·53 enrolled

Cataract1 trial

Evaluation of Anxiolysis and Pain Associated With Retrobulbar Eye Block for Cataract Surgery : Melatonin Versus Gabapentin

Completed·QQazvin University Of Medical Sciences·Phase 1/2·NCT01200641·90 enrolled

Schizophrenia1 trial

Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia

Completed·LLone Baandrup·Phase 4·NCT01431092·86 enrolled

Side Effects1 trial

Melatonin for Prevention of Metabolic Side Effects of Olanzapine

Completed·GGuilan University of Medical Sciences·Phase 2·NCT01593774·36 enrolled

Low Anterior Resection Syndrome1 trial

The Effect of Melatonin in Patients With Low Anterior Resection Syndrome

Unknown status·IIsmail Gögenur·Phase 2·NCT05042700·21 enrolled

Cognitive Deficit1 trial

Melatonin Intervention For Neurocognitive Deficits in the St. Jude Lifetime Cohort

Completed·SSt. Jude Children's Research Hospital·Phase 3·NCT01700959·911 enrolled

Premedication1 trial

The Premedication Properties of Oral Melatonin in Pediatrics Undergoing Therapeutic Cardiac Catheterization

Unknown status·—·N/A·NCT06031961·80 enrolled

Neurodevelopmental Disorders1 trial

Improving Sleep of Children With Neurodevelopmental Disorders: Pulsed Current Stimulation Versus Melatonin

Unknown status·KKK Women's and Children's Hospital·N/A·NCT06236191·40 enrolled

Dexmedetomidine1 trial

The Effect of Dexmedetomidine, Melatonin and Pregabalin

Unknown status·EEgymedicalpedia·Phase 1·NCT05829148·120 enrolled

Septic Shock1 trial

Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock

Unknown status·—·Phase 3·NCT01858909·110 enrolled

Melanoma1 trial

Comparison of Melatonin or Metformin and Dacarbazine Combination Versus Dacarbazine Alone in Disseminated Melanoma

Terminated·NN.N. Petrov National Medical Research Center of Oncology·Phase 2·NCT02190838·57 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction

Not yet recruiting·—·N/A·NCT07096635·50 enrolled

Tolerance1 trial

Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene

Completed·UUniversity of Helsinki·Phase 3·NCT01705639·45 enrolled

Relapsing-Remitting Multiple Sclerosis1 trial

Melatonin in Relapsing-Remitting Multiple Sclerosis Patients

Completed·TTehran University of Medical Sciences·Phase 2·NCT01279876·25 enrolled

Wound Healing1 trial

Effect of Melatonin on Palatal Wound Healing (Randomized Controlled Clinical Trial)

Unknown status·SSalma Nabil·Phase 2·NCT05122130·26 enrolled

Sleep1 trial

RECOVER-SLEEP: Platform Protocol

Completed·—·Phase 2·NCT06404086·830 enrolled

Delayed Sleep Phase Syndrome1 trial

Synchronization and Desynchronization Between Circadian Rhythms in Patients With Delayed Sleep Phase Syndrome (DSPS)

Unknown status·SSheba Medical Center·Phase 1·NCT00282061

Pressure Ulcers1 trial

Clinical Trial for the Evaluation of Melatonin in the Treatment of Pressure Ulcers

Not yet recruiting·FFundacion Rioja Salud·N/A·NCT06421454·50 enrolled

Autism1 trial

Melatonin Dose-effect Relation in Childhood Autism

Completed·RRennes University Hospital·Phase 2·NCT01780883·34 enrolled

Antipsychotics1 trial

Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics

Completed·IInstituto Nacional de Psiquiatría Dr. Ramón de la Fuente·Phase 4·NCT01811160·50 enrolled

Oral Mucositis1 trial

Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients

Completed·KKhon Kaen University·Phase 2·NCT02430298·39 enrolled

Actinic Keratoses1 trial

Gene and Protein Expression Profiles After Treatment of Actinic Keratoses

Unknown status·IIsmail Gögenur·Phase 2·NCT05740969·48 enrolled

Toxicity1 trial

Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes

Unknown status·UUniversity of Guadalajara·Phase 2·NCT03848533·42 enrolled

Lennox-Gastaut syndrome1 trial

Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects

Withdrawn·IInstitution de Lavigny·Phase 4·NCT01370486

Ischemia1 trial

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT02251041·143 enrolled

Prospective1 trial

Impact of Melatonin on IVF/ICSI Outcomes in Prospective Poor Responders

Unknown status·—·Phase 2/3·NCT02993588·100 enrolled

Pilot Study1 trial

Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study

Completed·—·Phase 3·NCT01566474·80 enrolled

Post-Operative Delirium1 trial

The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries

Completed·—·Phase 4·NCT07475156·100 enrolled

Advanced Cancer1 trial

Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00513357·82 enrolled

Atopic Dermatitis1 trial

Treatment of Nighttime Pruritus in Atopic Dermatitis

Withdrawn·UUniversity of Nebraska·Phase 1·NCT03688464

Combination Therapy1 trial

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

Recruiting·MM.D. Anderson Cancer Center·Phase 2/3·NCT05474846·188 enrolled

Randomized Controlled Trial1 trial

Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

Terminated·SShriners Hospitals for Children·Phase 2·NCT01598259·10 enrolled

Peripheral Neuropathy1 trial

Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy

Recruiting·—·Phase 2·NCT07036796·60 enrolled

Total Hip Arthroplasty1 trial

Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty

Recruiting·TTanta University·N/A·NCT06768580·135 enrolled

Orthostatic Hypotension1 trial

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension

Terminated·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 1·NCT02963181·10 enrolled

Carotid Endarterectomy1 trial

Melatonin in Patients Under Carotid Endarterectomy

Completed·PPeking Union Medical College Hospital·Phase 4·NCT03115034·60 enrolled

Enuresis1 trial

The Effect of Melatonin on Nocturnal Enuresis

Unknown status·UUniversity of Aarhus·Phase 2·NCT01575678·40 enrolled

Orthognathic Surgery1 trial

The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery

Suspended·TThe University of Hong Kong·Phase 1·NCT03995004·87 enrolled

Metabolic Syndrome1 trial

Melatonin and the Metabolic Syndrome

Completed·EEmory University·Phase 2·NCT01038921·39 enrolled

Tardive Dyskinesia1 trial

Melatonin Treatment for Tardive Dyskinesia in Schizophrenia

Completed·—·N/A·NCT01391390·120 enrolled

Heart Failure1 trial

Melatonin Supplementation to Improve Sleep in Patients With Heart Failure

Withdrawn·—·Phase 2·NCT00869869

Psychiatric Disorder1 trial

Efficacy of Melatonin, Low-dose Quetiapine, or Placebo in Patients With Psychiatric Disorders and Comorbid Insomnia

Recruiting·LLone Baandrup·Phase 2/3·NCT06062953·255 enrolled

Anxiety1 trial

Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively

Completed·UUniversity of Jordan·Phase 3·NCT06103188·87 enrolled

Joint Replacement Surgery1 trial

Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

Completed·HHospital for Special Surgery, New York·N/A·NCT01505465·50 enrolled

Gestational Diabetes1 trial

Melatonin for Glycemic Control in Gestational Diabetes Mellitus

Not yet recruiting·OObstetrics & Gynecology Hospital of Fudan University·Phase 2·NCT07369284·150 enrolled

Insulin resistance1 trial

Insulin Resistance in Patients After Carotid Revascularization

Unknown status·PPeking Union Medical College Hospital·Phase 4·NCT03419767·60 enrolled

Kidney Injury1 trial

Melatonin for Prevention of Kidney Injury

Recruiting·RRutgers, The State University of New Jersey·Phase 3·NCT05084196·300 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis

Terminated·FFundación Pública Andaluza para la gestión de la Investigación en Sevilla·Phase 1/2·NCT03540485·25 enrolled

Maintenance Treatment1 trial

The Contribution of Melatonin Vs. Placebo in Benzodiazepine Withdrawal in Methadone Maintenance Treatment Patients

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT00261183·100 enrolled

Dental Implant1 trial

Evaluation of Melatonin Application of Immediate Dental Implant

Completed·—·Phase 4·NCT03689998·24 enrolled

Tranexamic Acid1 trial

Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma

Active, not recruiting·TThammasat University·Phase 4·NCT07034560·75 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Melatonin and Clonazepam for IRBD

Completed·KKyung Hee University Hospital at Gangdong·N/A·NCT03255642·34 enrolled

Necrotizing Enterocolitis1 trial

Efficacy Of Oral Melatonin To Prevent Necrotizing Enterocolitis

Completed·IIlocos Training and Regional Medical Center·Phase 1/2·NCT05033639·100 enrolled

Sleep-Wake Disorder1 trial

Efficacy and Safety of Circadin for Non-24 Hour Sleep-Wake Disorder in Totally Blind Subjects

Completed·NNeurim Pharmaceuticals Ltd.·Phase 2·NCT00972075·13 enrolled

Injury1 trial

Effects of Melatonin on Reperfusion Injury

Unknown status·—·N/A·NCT03303378·190 enrolled

Hematoma1 trial

Oral Melatonin as Premedication During MAC for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation

Completed·—·Phase 1·NCT03732963·40 enrolled

Cardiomyopathy1 trial

Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy

Recruiting·TTanta University·Phase 3·NCT06846086·46 enrolled

Preoperative1 trial

The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy

Completed·—·Phase 1·NCT04959825·30 enrolled

Cerebral Palsy1 trial

Melatonin for Cerebral Palsy Children's Sleep and Health

Completed·—·N/A·NCT04392063·40 enrolled

Retinopathy1 trial

Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy

Not yet recruiting·MMohsen Pourazizi·Phase 2/3·NCT06809751·48 enrolled

Total Joint Arthroplasty1 trial

Melatonin Use After Primary Total Joint Arthroplasty

Completed·NNYU Langone Health·Phase 1·NCT04795336·294 enrolled

Unspecified2 trials

Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers

Completed· Biogen logo

Biogen·Phase 1·NCT02691702·97 enrolled

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

Sources

References

[1]
ClinicalTrials.gov — 280 trial records for Melatonin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Circadin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Melatonin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Melatonin. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Neurim Pharmaceuticals Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Melatonin Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: NNeurim Pharmaceuticals Ltd.